- Synthetic Strategies for Thienopyrrolidinones as ways to make Modified ThiolutinSusnik, Markus Peter, 2006, , ,
Cas no 89499-44-5 (Methyl 4-amino-5-chlorothiophene-2-carboxylate)
Methyl 4-amino-5-chlorothiophene-2-carboxylate is a heterocyclic compound featuring a thiophene core substituted with an amino group at the 4-position, a chlorine atom at the 5-position, and a carboxylate ester at the 2-position. This structure makes it a valuable intermediate in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. The presence of both amino and ester functionalities enhances its reactivity, enabling further derivatization. Its stability under standard conditions and high purity make it suitable for precise synthetic applications. The compound is commonly utilized in the preparation of biologically active molecules, including potential therapeutic agents, due to its versatile reactivity profile.
89499-44-5 structure
Product Name:Methyl 4-amino-5-chlorothiophene-2-carboxylate
CAS No:89499-44-5
MF:C6H6ClNO2S
MW:191.635339260101
MDL:MFCD00508459
CID:711826
Update Time:2025-05-27
Methyl 4-amino-5-chlorothiophene-2-carboxylate Chemical and Physical Properties
Names and Identifiers
-
- Methyl 4-amino-5-chlorothiophene-2-carboxylate
- 2-Thiophenecarboxylicacid, 4-amino-5-chloro-, methyl ester
- 4-Amino-5-chlorothiophene-2-carboxylic acid methyl ester
- Methyl 4-amino-5-chloro-2-thiophenecarboxylate (ACI)
-
- MDL： MFCD00508459
- Inchi： 1S/C6H6ClNO2S/c1-10-6(9)4-2-3(8)5(7)11-4/h2H,8H2,1H3
- InChI Key： RUAIJHHRCIHFEV-UHFFFAOYSA-N
- SMILES： ClC1=C(C=C(C(=O)OC)S1)N
Computed Properties
- Exact Mass: 190.98100
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 11
- Rotatable Bond Count: 2
- Complexity: 167
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: 2.1
Experimental Properties
- PSA: 80.56000
- LogP: 2.35150
Methyl 4-amino-5-chlorothiophene-2-carboxylate Security Information
- Signal Word：Warning
- Hazard Statement： H302-H315-H319-H332-H335
- Warning Statement： P261-P280-P305+P351+P338
- Hazard Category Code： 36/37/38
- Safety Instruction： 26-36/37
- Storage Condition：Keep in dark place,Inert atmosphere,2-8°C
Methyl 4-amino-5-chlorothiophene-2-carboxylate Customs Data
- HS CODE：2934999090
- Customs Data：
China Customs Code:
2934999090Overview:
2934999090. Other heterocyclic compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to
Summary:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Methyl 4-amino-5-chlorothiophene-2-carboxylate Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | AD459-1g |
Methyl 4-amino-5-chlorothiophene-2-carboxylate |
89499-44-5 | 97% | 1g |
818CNY | 2021-05-08 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | AD459-5g |
Methyl 4-amino-5-chlorothiophene-2-carboxylate |
89499-44-5 | 97% | 5g |
2744CNY | 2021-05-08 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | AD459-250mg |
Methyl 4-amino-5-chlorothiophene-2-carboxylate |
89499-44-5 | 97% | 250mg |
326CNY | 2021-05-08 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | AD459-25g |
Methyl 4-amino-5-chlorothiophene-2-carboxylate |
89499-44-5 | 97% | 25g |
9820CNY | 2021-05-08 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | AD459-10g |
Methyl 4-amino-5-chlorothiophene-2-carboxylate |
89499-44-5 | 97% | 10g |
4906CNY | 2021-05-08 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | M847765-1g |
Methyl 4-amino-5-chlorothiophene-2-carboxylate |
89499-44-5 | 97% | 1g |
681.00 | 2021-05-17 | |
| Matrix Scientific | 071998-1g |
Methyl 4-amino-5-chlorothiophene-2-carboxylate, 95+% |
89499-44-5 | 95+% | 1g |
$278.00 | 2023-09-05 | |
| Matrix Scientific | 071998-5g |
Methyl 4-amino-5-chlorothiophene-2-carboxylate, 95+% |
89499-44-5 | 95+% | 5g |
$798.00 | 2023-09-05 | |
| Matrix Scientific | 071998-10g |
Methyl 4-amino-5-chlorothiophene-2-carboxylate, 95+% |
89499-44-5 | 95+% | 10g |
$1250.00 | 2023-09-05 | |
| Chemenu | CM199722-1g |
Methyl 4-amino-5-chlorothiophene-2-carboxylate |
89499-44-5 | 96% | 1g |
$154 | 2023-01-18 |
Methyl 4-amino-5-chlorothiophene-2-carboxylate Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Water
Reference
Production Method 2
Reaction Conditions
Reference
- Reductive acetylation of nitrocarboxylic acids or esters of the thiophene and furan seriesGoldfarb, Ya. L.; Bulgakova, V. N.; Fabrichnyi, B. P., Khimiya Geterotsiklicheskikh Soedinenii, 1983, (12), 1626-9
Methyl 4-amino-5-chlorothiophene-2-carboxylate Raw materials
- 2-Thiophenecarboxylic acid, 4-amino-5-chloro-, hydrochloride
- Methyl 5-chloro-4-nitrothiophene-2-carboxylate
Methyl 4-amino-5-chlorothiophene-2-carboxylate Preparation Products
Methyl 4-amino-5-chlorothiophene-2-carboxylate Related Literature
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Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
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Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007
-
Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
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Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
-
Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
89499-44-5 (Methyl 4-amino-5-chlorothiophene-2-carboxylate) Related Products
- 107818-51-9(methyl 3-amino-5-chlorothiophene-2-carboxylate)
- 89499-41-2(2-Thiophenecarboxylic acid, 4-amino-5-chloro-)
- 1520257-98-0(3-amino-5-chlorothiophene-2-carboxylic acid)
- 2228891-40-3(methyl 3-amino-5-chlorothiophene-2-carboxylate hydrochloride)
- 89499-36-5(2-Thiophenecarboxylic acid, 4-amino-5-chloro-, hydrochloride)
- 89499-29-6(2-Thiophenecarboxylic acid, 4-(acetylamino)-5-chloro-, methyl ester)
- 89499-43-4(Methyl 4-aminothiophene-2-carboxylate)
- 35475-03-7(Methyl 5-chlorothiophene-2-carboxylate)
- 89640-03-9(Ethyl 5-chloro-4-nitrothiophene-2-carboxylate)
- 57800-76-7(Methyl 5-chloro-4-nitrothiophene-2-carboxylate)
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