Production Method 1

96999-01-8

89544-84-3

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ,  Water ;  12 h, rt

Reference

General and Scalable Approach to Trifluoromethyl-substituted Cyclopropanes

Ahunovych, Volodymyr; Klipkov, Anton A.; Bugera, Maksym; Tarasenko, Karen; Trofymchuk, Serhii; et al, Journal of Organic Chemistry, 2023, 88(6), 3859-3870

Production Method 2

96999-01-8

89544-84-3

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ,  Water ;  0 °C; 12 h, rt

Reference

General and scalable approach to trifluoromethyl-substituted cyclopropanes

Ahunovych, Volodymyr; Klipkov, Anton A.; Bugera, Maksym; Tarasenko, Karen; Trofymchuk, Serhii; et al, ChemRxiv, 2023, 1, 1-6

Production Method 3

29547-04-4

89544-84-3

Reaction Conditions

Reference

g-Butyrolactone

Boukouvalas, John, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, ,

Production Method 4

22059-21-8

89544-84-3

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Potassium bromide Catalysts: Formic acid

Reference

Diazotization of 1-aminocyclopropanecarboxylic acid. Solution chemistry of oxaspiropentanone

Pirrung, Michael C.; Brown, William L., Journal of the American Chemical Society, 1990, 112(17), 6388-9

Production Method 5

96999-01-8

89544-84-3

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Solvents: Diethyl ether ,  Toluene ,  Water

Reference

Trispiro[2.1.2.1.2.1]dodecane-4,8,12-trione and other oligomers of carbonylcyclopropane. The organozinc route

Hoffmann, H. Martin R.; Eggert, Ulrike; Walenta, Angela; Weineck, Edeltraut; Schomburg, Dietmar; et al, Journal of Organic Chemistry, 1989, 54(26), 6096-100

Production Method 6

96999-01-8

89544-84-3

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide ,  Water Solvents: Water

Reference

Trispiro[2.1.2.1.2.1]dodecane-4,8,12-trione

Hoffmann, H. M. R.; Walenta, Angela; Eggert, Ulrike; Schamburg, Dietmar, Angewandte Chemie, 1985, 97(7), 599-600

1-Bromocyclopropanecarboxylic acid Raw materials

• methyl 1-bromocyclopropane-1-carboxylate
• 1-aminocyclopropane-1-carboxylic acid
• methyl 2,4-dibromobutanoate

1-Bromocyclopropanecarboxylic acid Preparation Products

• 1-Bromocyclopropanecarboxylic acid (89544-84-3)

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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Cyclopropanecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Cyclopropanecarboxylic acids and derivatives Cyclopropanecarboxylic acids

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• 95338-79-7(2-Bromo-2-methylbutanoic acid)
• 32122-23-9(1-bromocyclobutane-1-carboxylic acid)
• 56447-24-6(1-bromocyclopentane-1-carboxylic acid)
• 5456-23-5(2-Bromo-2-ethylbutanoic acid)
• 2681-94-9((2R)-2-bromobutanoic acid)
• 20629-61-2(2-bromobutyrate)
• 41242-50-6(2-Bromo-2-methylbutyric acid)
• 32659-49-7((2S)-2-bromobutanoic acid)
• 80-58-0(2-Bromobutyric acid)