Production Method 1

89487-91-2

Reaction Conditions

1.1 Reagents: Iodine ,  Ammonia ,  Potassium iodide Solvents: Water ;  0 - 5 °C; 2 h, 0 - 5 °C; overnight, cooled
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 4 - 5

Reference

Synthesis of Dihydrobenzofurans via Palladium-Catalyzed Annulation of 1,3-Dienes by o-Iodoaryl Acetates

Rozhkov, Roman V.; Larock, Richard C., Journal of Organic Chemistry, 2010, 75(12), 4131-4134

Production Method 2

89487-91-2

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Sulfuric acid Solvents: Dimethyl sulfoxide ,  Water ;  0 °C
1.2 Reagents: Potassium iodide ;  rt

Reference

Chemistry of aminophenols. Part 3: First synthesis of nitrobenzo[b]furans via a coupling-cyclization approach

Dai, Wei-Min; Lai, Kwong Wah, Tetrahedron Letters, 2002, 43(51), 9377-9380

Production Method 3

89487-91-2

Reaction Conditions

1.1 Reagents: Hydrochloric acid ,  Sodium iodide ,  Sodium chlorite Solvents: Methanol ,  Water ;  0 °C; 0 °C → rt; 18 h, rt

Reference

Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1

Beale, Thomas M.; Bond, Peter J.; Brenton, James D.; Charnock-Jones, D. Stephen; Ley, Steven V.; et al, Bioorganic & Medicinal Chemistry, 2012, 20(5), 1749-1759

Production Method 4

89487-91-2

Reaction Conditions

1.1 Reagents: Potassium iodide ,  Potassium bromate Catalysts: Hydrochloric acid Solvents: Methanol ,  Water ;  2 h, 60 °C

Reference

A convenient procedure for the iodination of arenes

Sathiyapriya, R.; Karunakaran, R. Joel, Journal of Chemical Research, 2006, (9), 575-576

Production Method 5

89487-91-2

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Morpholine, compd. with iodine (1:1) Solvents: Water ;  15 min, rt; 15 min, rt; 15 min, rt; 15 min, rt; 15 min, rt; 15 min, rt; 15 min, rt; 15 min, rt
1.2 Reagents: Phosphoric acid Solvents: Water ;  pH 2, cooled; 24 h, cooled

Reference

Iodination of phenols in water using easy to handle amine-iodine complexes

da Frota, Livia C. R. M.; Canavez, Raquel C. P.; da Silva Gomes, Sara L.; Costa, Paulo R. R.; da Silva, Alcides J. M., Journal of the Brazilian Chemical Society, 2009, 20(10), 1916-1920

Production Method 6

89487-91-2

Reaction Conditions

1.1 Reagents: Potassium bisulfate ,  Potassium iodide Catalysts: Chromate(1-), chlorotrioxo-, (T-4)-, hydrogen, compd. with isoquinoline (1:1:1) Solvents: 1,2-Dichloroethane ,  Water ;  30 - 40 min, rt

Reference

Isoquinolinium Dichromate and Chlorochromate as Efficient Catalysts for Oxidative Halogenation of Aromatic Compounds Under Acid-Free Conditions

Rao, A. Sambashiva; Rajanna, K. C.; Reddy, K. Rajendar; Kulkarni, Subhash, Synthesis and Reactivity in Inorganic, 2016, 46(6), 832-837

Production Method 7

89487-91-2

Reaction Conditions

1.1 Reagents: Iodine ,  Sodium nitrite Solvents: Methanol ,  Water ;  0.5 h, rt
1.2 5 - 10 °C; 6.0 h, rt
1.3 Reagents: Sodium thiosulfate Solvents: Water ;  rt

Reference

A green reagent for the iodination of phenols

Kiran, Y. B.; Konakahara, Takeo; Sakai, Norio, Synthesis, 2008, (15), 2327-2332

Production Method 8

89487-91-2

Reaction Conditions

1.1 Reagents: Iodine ,  Hydrochloric acid ,  Ammonia ,  Potassium iodide Solvents: Water ;  24 h, 0 - 5 °C

Reference

A facile and efficient synthesis of dronedarone hydrochloride

Li, Feng; Jin, Chunhua; Zou, Jianwei; Wu, Jun, Bulletin of the Korean Chemical Society, 2014, 35(7), 1970-1972

Production Method 9

89487-91-2

Reaction Conditions

1.1 Reagents: Iodine ,  Selectfluor Solvents: 1-Butyl-3-methylimidazolium hexafluorophosphate ;  rt; 24 h, 80 °C

Reference

Regioselective iodination of arenes in ionic liquids mediated by the Selectfluor reagent F-TEDA-BF4

Chiappe, Cinzia; Pieraccini, Daniela, ARKIVOC (Gainesville, 2002, (11), 249-255

Production Method 10

89487-91-2

Reaction Conditions

1.1 Reagents: Montmorillonite ((Al1.33-1.67Mg0.33-0.67)(Ca0-1Na0-1)0.33Si4(OH)2O10.xH2O) ,  Iodine ,  Potassium ferrate (K2FeO4) Solvents: Hexane ;  150 min, rt → reflux

Reference

Efficient iodination of aromatic compounds using potassium ferrate supported on montmorillonite

Keipour, Hoda; Khalilzadeh, Mohammad A.; Mohtat, Bita; Hosseini, Abolfazl; Zareyee, Daryoush, Chinese Chemical Letters, 2011, 22(12), 1427-1430

Production Method 11

89487-91-2

Reaction Conditions

1.1 Reagents: Potassium iodide ,  Phosphonium, (2-methylphenyl)triphenyl-, perchlorate (1:1) Solvents: Acetonitrile ;  4.5 h, reflux

Reference

Regioselective iodination of aromatic compounds with potassium iodide in the presence of benzyltriphenylphosphonium perchlorate

Albadi, Jalal; Abedini, Masoumeh; Iravani, Nasir, Chinese Chemical Letters, 2012, 23(3), 261-264

Production Method 12

89487-91-2

Reaction Conditions

1.1 Reagents: Potassium iodide ,  Phosphonium, triphenyl(phenylmethyl)-, peroxymonosulfate (1:1) Solvents: Acetonitrile ;  6 h, rt

Reference

Highly selective iodination of phenols using potassium iodide and benzyltriphenylphosphonium peroxymonosulfate

Hajipour, Abdol Reza; Adibi, Hadi, Journal of Chemical Research, 2004, (4), 294-295

Production Method 13

89487-91-2

Reaction Conditions

1.1 Reagents: Chloramine-T ,  Sodium iodide Solvents: Dimethylformamide ;  rt

Reference

A simple acromelic acid analog potentially useful for receptor photoaffinity labeling and biochemical studies

Furuta, Kyoji; Wang, Guang Xing; Minami, Toshiaki; Nishizawa, Mikio; Ito, Seiji; et al, Tetrahedron Letters, 2004, 45(20), 3933-3936

Production Method 14

89487-91-2

Reaction Conditions

1.1 Reagents: Iodine ,  Ammonia ,  Potassium iodide Solvents: Water ;  0 °C; 0 °C → rt; 4 d, rt; rt; 2 d, rt; rt; 17 d, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 3

Reference

What Is the Structure of the Antitubercular Natural Product Eucapsitrione?

Pullella, Glenn A.; Wild, Duncan A.; Nealon, Gareth L.; Elyashberg, Mikhail; Piggott, Matthew J., Journal of Organic Chemistry, 2017, 82(14), 7287-7299

Production Method 15

89487-91-2

Reaction Conditions

1.1 Reagents: Iodine ,  Silver nitrate ;  1 min, rt
1.2 10 min, rt; 10 - 30 min, rt

Reference

Solvent-free iodination of arenes using iodine-silver nitrate combination

Yusubov, Mekhman S.; Tveryakova, Elena N.; Krasnokutskaya, Elena A.; Perederyna, Irina A.; Zhdankin, Viktor V., Synthetic Communications, 2007, 37(8), 1259-1265

Production Method 16

89487-91-2

Reaction Conditions

1.1 Reagents: Iodine ,  Sodium nitrite Solvents: Methanol ,  Water ;  1.5 - 6 h, rt

Reference

Sodium nitrite

McCullough, Kevin J., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2016, 1, 1-11

Production Method 17

89487-91-2

Reaction Conditions

1.1 Reagents: tert-Butyl hydroperoxide ,  Potassium iodide Solvents: Methanol ,  Water ;  30 min, rt; 8 h, rt
1.2 Reagents: Sodium thiosulfate

Reference

Mild and efficient oxy-iodination of alkynes and phenols with potassium iodide and tert-butyl hydroperoxide

Rajender Reddy, K.; Venkateshwar, M.; Uma Maheswari, C.; Santhosh Kumar, P., Tetrahedron Letters, 2010, 51(16), 2170-2173

2-Iodo-4-nitrophenol Preparation Products

• 2-Iodo-4-nitrophenol (89487-91-2)

• 1. An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting?
  Lab Chip, 2019,19, 524-535
• 2. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
• 3. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 4. Alt-proteins: A promising future
• 5. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873

• 21784-73-6(4-Iodo-2-nitrophenol)
• 5399-03-1(2-Iodo-4-nitroanisole)
• 197243-48-4(2-Iodo-3-nitrophenol)
• 66166-40-3(4-nitro-2-phenyliodoniophenolate)
• 13073-26-2(2-Iodo-6-nitrophenol)
• 31106-75-9(1,3-Diiodo-2-methoxy-5-nitrobenzene)
• 305-85-1(2,6-Diiodo-4-nitrophenol)
• 5458-84-4(2-Iodo-5-nitroanisole)
• 21969-05-1(1-(4-Iodophenoxy)-4-nitrobenzene)
• 197243-46-2(2-Iodo-5-nitrophenol)