- Preparation of dihydropyridinedicarboxylic acid esters as cardiovascular agents, Japan, , ,
Cas no 89226-75-5 (Manidipine dihydrochloride)
Manidipine dihydrochloride structure
Product Name:Manidipine dihydrochloride
CAS No:89226-75-5
MF:C35H39ClN4O6
MW:647.160368204117
MDL:MFCD00896434
CID:61240
PubChem ID:160871248
Update Time:2024-11-26
Manidipine dihydrochloride Chemical and Physical Properties
Names and Identifiers
-
- MANIDIPINE DIHYDROCHLORIDE
- Manidipine 2HCl
- 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
- CV-4093
- Manidipine Dihydroch
- MANIDIPINE HCL
- manidipine hydrochloride
- CV4093
- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester Dihydrochloride
- 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Dihydrochloride
- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride
- Franidipine hydrochloride
- Manidipine.2HCl
- Manidipine (dihydrochloride)
- (+-)-Manidipine hydrochloride
- CV 4093
- Calslot
- DSSTox_CID_796
- DSSTox_RID_75794
- DSSTox_GSID_20796
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(diphenyl
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride (9CI)
- (±)-Manidipine dihydrochloride
- Manidipine dihydrochloride
-
- MDL： MFCD00896434
- Inchi： 1S/C35H38N4O6.ClH/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27;/h4-16,23,32-33,36H,17-22H2,1-3H3;1H
- InChI Key： UFIXGLLGFBWKAV-UHFFFAOYSA-N
- SMILES： Cl.O=C(C1C(C2C=C([N+](=O)[O-])C=CC=2)C(C(OCCN2CCN(C(C3C=CC=CC=3)C3C=CC=CC=3)CC2)=O)=C(C)NC=1C)OC
Computed Properties
- Exact Mass: 646.25600
- Monoisotopic Mass: 682.232
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 9
- Heavy Atom Count: 47
- Rotatable Bond Count: 11
- Complexity: 1090
- Covalently-Bonded Unit Count: 3
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 1
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: 5
- XLogP3: nothing
- Topological Polar Surface Area: 117
Experimental Properties
- Color/Form: Powder
- Melting Point: 228-235°C
- Boiling Point: 722 °C at 760 mmHg
- Flash Point: 722 °C at 760 mmHg
- Water Partition Coefficient: Soluble in DMSO. Slightly soluble in water and ethanol /n
- PSA: 116.93000
- LogP: 6.48280
- Merck: 5743
Manidipine dihydrochloride Security Information
-
Symbol:
- Prompt：dangerous
- Signal Word：Warning
- Hazard Statement： H301+H311+H331
- Warning Statement： P261-P264-P270-P271-P280-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P403+P233-P405-P501
- Hazardous Material transportation number：UN 2811 6.1/PG III
- RTECS：US7975300
- HazardClass：6.1
- PackingGroup：III
- Toxicity：LD50 in male, female mice, male, female rats (mg/kg): 387, 340, 222, 199 s.c.; 62.2, 68.0, 66.5, 48.8 i.p.; 190, 171, 247, 156 orally (Chiba)
- Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
Manidipine dihydrochloride Customs Data
- HS CODE：2942000000
- Customs Data：
China Customs Code:
2933990090Overview:
2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Manidipine dihydrochloride Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| YUN NAN XI LI SHENG WU JI SHU GU FEN Co., Ltd. | BBP80288-5mg |
Manidipine dihydrochloride |
89226-75-5 | 98.0% | 5mg |
￥260 | 2021-05-07 | |
| MedChemExpress | HY-17403-10mM*1mLinDMSO |
Manidipine dihydrochloride |
89226-75-5 | 98.87% | 10mM*1mLinDMSO |
￥605 | 2022-05-18 | |
| MedChemExpress | HY-17403-50mg |
Manidipine dihydrochloride |
89226-75-5 | 99.91% | 50mg |
￥450 | 2025-04-15 | |
| MedChemExpress | HY-17403-100mg |
Manidipine dihydrochloride |
89226-75-5 | 99.91% | 100mg |
￥765 | 2025-04-15 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M129521-500mg |
Manidipine dihydrochloride |
89226-75-5 | ≥99% | 500mg |
￥141.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M129521-25mg |
Manidipine dihydrochloride |
89226-75-5 | ≥99% | 25mg |
￥29.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M129521-1g |
Manidipine dihydrochloride |
89226-75-5 | ≥99% | 1g |
￥233.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M129521-50mg |
Manidipine dihydrochloride |
89226-75-5 | ≥99% | 50mg |
￥41.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M129521-100mg |
Manidipine dihydrochloride |
89226-75-5 | ≥99% | 100mg |
￥68.90 | 2023-09-02 | |
| TI XI AI ( SHANG HAI ) HUA CHENG GONG YE FA ZHAN Co., Ltd. | M2225-1G |
Manidipine Dihydrochloride |
89226-75-5 | >98.0%(T)(HPLC) | 1g |
￥690.00 | 2024-04-15 |
Manidipine dihydrochloride Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Dibutylamine Solvents: Isopropanol
Reference
Manidipine dihydrochloride Raw materials
- 3-Nitrobenzaldehyde
- Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester
- methyl (E)-3-aminobut-2-enoate
Manidipine dihydrochloride Preparation Products
Manidipine dihydrochloride Suppliers
Amadis Chemical Company Limited
Gold Member
Audited Supplier
(CAS:89226-75-5)Manidipine dihydrochloride
Order Number:A1205565
Stock Status:in Stock
Quantity:5g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 03:42
Price ($):162.0
Email:[email protected]
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier
(CAS:89226-75-5)Manidipine Dihydrochloride, ≥ 98.0%
Order Number:LE17237
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:15
Price ($):discuss personally
Email:[email protected]
Manidipine dihydrochloride Related Literature
-
Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
-
Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
-
Philipp Traber,Stephan Kupfer,Stefanie Gr?fe,Isabelle Baussanne,Martine Demeunynck,Jean-Marie Mouesca,Serge Gambarelli,Vincent Artero,Murielle Chavarot-Kerlidou Chem. Sci., 2018,9, 4152-4159
-
Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
89226-75-5 (Manidipine dihydrochloride) Related Products
- 63675-72-9(Nisoldipine)
- 39562-25-9(Isopropyl 2-(3-nitrobenzylidene)acetoacetate)
- 39562-70-4(Nitrendipine)
- 6238-13-7(3-Quinuclidinol hydrochloride)
- 120092-68-4(Manidipine)
- 74936-72-4(5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid)
- 66085-59-4(Nimodipine)
- 89226-50-6(Manidipine)
- 21829-25-4(Nifedipine)
- 22609-73-0(Niludipine)
