Production Method 1

6563-10-6

891842-50-5

Reaction Conditions

1.1 Reagents: Dimethylformamide ,  Phosphoric tribromide Solvents: Dichloromethane ;  0 °C; 0 °C → 25 °C; < 6 h, 25 °C
1.2 Reagents: Sodium carbonate Solvents: Water ;  pH 7 - 8, 25 °C

Reference

A highly practical and convenient halogenation of fused heterocyclic N-oxides

Wang, Dong; Wang, Yuxi; Zhao, Junjie; Li, Linna; Miao, Longfei; et al, Tetrahedron, 2016, 72(38), 5762-5768

Production Method 2

6563-10-6

891842-50-5

Reaction Conditions

1.1 Reagents: Tetrabutylammonium bromide Solvents: Dichloromethane ;  10 min, rt
1.2 Reagents: p-Toluenesulfonic anhydride ;  overnight, rt

Reference

Regioselective Bromination of Fused Heterocyclic N-Oxides

Wengryniuk, Sarah E.; Weickgenannt, Andreas; Reiher, Christopher; Strotman, Neil A.; Chen, Ke; et al, Organic Letters, 2013, 15(4), 792-795

2-Bromo-6-chloroquinoline Raw materials

• Quinoline, 6-chloro-, 1-oxide

2-Bromo-6-chloroquinoline Preparation Products

• 2-Bromo-6-chloroquinoline (891842-50-5)

• 1. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 2. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
• 3. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 4. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 5. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Chloroquinolines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Haloquinolines Chloroquinolines

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