Production Method 1

88971-40-8

88971-40-8

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Ethyl acetate ,  Water ;  cooled

Reference

Monovalent and bivalent fibrin-specific MRI contrast agents for detection of thrombus

Nair, Shrikumar A.; Kolodziej, Andrew F.; Bhole, Gandhali; Greenfield, Matthew T.; McMurry, Thomas J.; et al, Angewandte Chemie, 2008, 47(26), 4918-4921

Production Method 2

24424-99-5

73259-81-1

88971-40-8

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: 1,4-Dioxane ,  Water ;  4 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Dichloromethane ,  Water ;  pH 2.5

Reference

Tetrahydroimidazo[1,2-a]pyrazine Derivatives: Synthesis and Evaluation as Gαq-Protein Ligands

Kueppers, Jim; Benkel, Tobias ; Annala, Suvi; Kimura, Kenichi; Reinelt, Lisa; et al, Chemistry - A European Journal, 2020, 26(55), 12615-12623

Production Method 3

24424-99-5

4033-39-0

88971-40-8

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: tert-Butanol ,  Water ;  15 °C; 4 h, 15 °C
1.2 Reagents: Potassium bisulfate Solvents: Water ;  pH 2 - 3

Reference

Synthesis and characterization of new first generation dendrimers with high-density amine groups

Jiang, De-hong; Zheng, Hu; Qi, Qing-rong, Huaxi Yaoxue Zazhi, 2010, 25(6), 647-649

Production Method 4

24424-99-5

4033-39-0

88971-40-8

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane ,  Water ;  15 min, rt
1.2 12 h, rt

Reference

Phenalenyl based platinum anticancer compounds with superior efficacy: design, synthesis, characterization, and interaction with nuclear DNA

Dutta, Pradip; Kumari, Smita; Paulraj, Justin; Sharma, Rupali; Vijaykumar, Gonela; et al, New Journal of Chemistry, 2021, 45(23), 10524-10533

Production Method 5

24424-99-5

1482-97-9

88971-40-8

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Acetone ,  Water ;  12 h, rt

Reference

Synthesis and nematicidal activity of piperazinedione derivatives based on the natural product Barettin

Sun, Haiyang; Li, Hui; Wang, Jiayi; Song, Gonghua, Chinese Chemical Letters, 2018, 29(6), 977-980

L-Alanine,N-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethoxy)carbonyl]amino]- Raw materials

• Di-tert-butyl dicarbonate
• (2S)-3-amino-2-(tert-butoxycarbonylamino)propanoic acid
• 2,3-Diaminopropionic acid hydrochloride
• L-2,3-Diaminopropionicacid
• L-Alanine,N-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethoxy)carbonyl]amino]-

L-Alanine,N-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethoxy)carbonyl]amino]- Preparation Products

• L-Alanine,N-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethoxy)carbonyl]amino]- (88971-40-8)

• 1. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 2. Enantiocontrolled construction of sistodiolynne, an unusual polyketide from the wood-decay fungus Sistrema raduloides
  Chem. Commun., 1997, 767-768
• 3. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 4. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
  Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327
• 5. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026

L-Alanine,N-[(1,1-Dimethylethoxy)Carbonyl]-3-[[(1,1-Dimethylethoxy)Carbonyl]Amino] (CAS No. 88971-40-8)

The compound L-Alanine,N-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethoxy)carbonyl]amino], also known by its CAS number 88971-40-8, is a significant molecule in the field of synthetic chemistry and biochemistry. This compound is a derivative of L-alanine, a naturally occurring amino acid that plays a crucial role in various biological processes. The introduction of the (1,1-dimethylethoxy)carbonyl group into the structure of L-alanine enhances its chemical properties, making it a valuable intermediate in the synthesis of complex molecules.

L-Alanine is one of the 20 standard amino acids that are essential for protein synthesis. Its structure consists of a central carbon atom bonded to an amino group (-NH2), a carboxyl group (-COOH), a hydrogen atom, and a methyl group (-CH3). The addition of the (1,1-dimethylethoxy)carbonyl group to L-alanine introduces steric hindrance and improves the molecule's stability. This modification is particularly useful in peptide synthesis, where protecting groups like the (1,1-dimethylethoxy)carbonyl group are employed to prevent unwanted side reactions.

The synthesis of L-Alanine,N-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethoxy)carbonyl]amino] involves multi-step chemical reactions. The process typically begins with the activation of L-alanine using an appropriate coupling agent. The (1,1-dimethylethoxy)carbonyl group is then introduced through a protection reaction. This step ensures that the amino and carboxyl groups are properly shielded during subsequent reactions. The final product is purified using chromatographic techniques to ensure high purity and quality.

In terms of applications, this compound is widely used in peptide synthesis as a building block for constructing more complex molecules. Its protected form allows for precise control over the reaction steps, making it ideal for synthesizing bioactive compounds such as peptides and proteins. Recent studies have highlighted its potential in drug discovery programs targeting various diseases.

Recent research has focused on optimizing the synthesis and application of this compound. For instance, scientists have explored new methods to enhance the efficiency of peptide bond formation using this compound as an intermediate. Additionally, advancements in analytical techniques have enabled better characterization of this compound's physical and chemical properties.

In conclusion, L-Alanine,N-[(1,1-dimethylethoxy)carbonyl]-3-[[(1,1-dimethylethoxy)carbonyl]amino] (CAS No. 88971-40-8) is a vital molecule in modern synthetic chemistry. Its unique structure and versatile applications make it an essential tool for researchers in various fields. As technology continues to evolve, this compound will likely find new uses in drug development and other areas of biotechnology.

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