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  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 2. An aptamer-based keypad lock system?
  Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
• 3. An automatic determination of thoria in thoria-urania mixtures
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• 4. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
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• 5. An aqueous ammonia sensor based on an inkjet-printed polyaniline nanoparticle-modified electrode
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Comprehensive Guide to 2,3-Diaminopropionic Acid Hydrochloride (CAS No. 1482-97-9): Properties, Applications, and Research Insights

2,3-Diaminopropionic acid hydrochloride (CAS No. 1482-97-9) is a specialized amino acid derivative gaining attention in biochemical and pharmaceutical research. This compound, often abbreviated as DAP-HCl, features a unique structure with two amino groups, making it a versatile building block for peptide synthesis and drug development. Researchers and industry professionals are increasingly exploring its potential due to its role in modulating biological pathways and its compatibility with green chemistry principles.

The growing demand for custom amino acids and peptide modifications has propelled interest in 2,3-diaminopropionic acid HCl. Recent studies highlight its utility in creating targeted drug delivery systems and bioconjugates, aligning with trends in personalized medicine. Its hydrochloride salt form (1482-97-9) offers enhanced solubility, a critical factor for in vitro applications and high-throughput screening workflows.

From a synthetic chemistry perspective, DAP-HCl serves as a precursor for heterocyclic compounds and chelating agents. Its dual amino functionality enables the formation of stable complexes with metal ions, relevant to catalysis research and material science. The compound’s stability under physiological pH conditions makes it particularly valuable for biomedical engineering applications, including tissue scaffold functionalization.

Analytical characterization of CAS 1482-97-9 typically involves HPLC purity testing and mass spectrometry verification. Quality control protocols emphasize the importance of low endotoxin levels for cell culture studies, a key consideration for researchers investigating immune response modulation. The compound’s chirality (available in both L- and D- forms) further expands its utility in stereoselective synthesis projects.

Environmental and safety profiles of 2,3-diaminopropionic acid hydrochloride comply with modern green chemistry metrics. Its biodegradability and absence of persistent bioaccumulative properties align with the pharmaceutical industry’s shift toward sustainable APIs. Storage recommendations typically suggest 2-8°C conditions under inert atmosphere to maintain optimal stability for long-term research use.

Emerging applications in neuroscience research have identified DAP-HCl derivatives as potential neurotransmitter analogs. The compound’s structural similarity to endogenous amino acids enables exploration of blood-brain barrier transport mechanisms. These developments correlate with increasing searches for blood-brain barrier penetrating compounds and neuroprotective agents in academic literature.

Technical specifications for 1482-97-9 often include detailed NMR spectra data and elemental analysis results, crucial for verification in GMP-compliant synthesis. The compound’s water solubility profile (>50 mg/mL) facilitates formulation development, addressing common challenges in peptide drug solubility enhancement strategies.

Market trends indicate rising procurement of 2,3-diaminopropionic acid HCl by contract research organizations and biotech startups focused on next-generation therapeutics. The compound’s appearance in patent filings related to ADC linkers (antibody-drug conjugates) and prodrug technologies demonstrates its growing importance in oncological research pipelines.

Comparative studies between diaminopropionic acid isomers reveal distinct biological activities, with the 2,3-configuration (1482-97-9) showing particular promise for enzyme inhibition studies. This specificity drives demand from researchers investigating allosteric modulation and protein-protein interactions in signal transduction pathways.

Future research directions for CAS 1482-97-9 may explore its potential in bioorthogonal chemistry applications and smart material design. The compound’s bifunctional nature positions it as a candidate for developing stimuli-responsive biomaterials, particularly in 3D bioprinting and regenerative medicine applications that require precise molecular control.

• 215652-51-0((2S,3R)-2,3-Diaminobutanoic acid dihydrochloride)
• 6018-56-0(D-2,3-Diaminopropionic Acid Hydrochloride)
• 54897-59-5(Dl-2,3-diaminopropionic acid, hydrochloride)
• 1915-96-4((2R)-2,3-diaminopropanoic acid)
• 515-94-6(2,3-Diaminopropanoic acid)
• 25880-75-5(Platinate(1-),(3-amino-L-alaninato-N,N')dichloro-, hydrogen, (SP-4-3)- (9CI))
• 121054-30-6((3S,2S)-2,3-Diaminobutyric Acid Dihydrochloride)
• 4033-39-0(L-2,3-Diaminopropionicacid)
• 18635-45-5(2,3-Diaminopropanoic Acid Hydrobromide)
• 16012-55-8(β-N-methylamino-L-alanine hydrochloride)