Production Method 1

1191-95-3

626-55-1

889687-37-0

Reaction Conditions

1.1 Reagents: Piperidine, 2,2,6,6-tetramethyl-, lithium salt (1:1) Solvents: Tetrahydrofuran ;  -85 °C; 25 min, -85 °C
1.2 Solvents: Tetrahydrofuran ;  15 min, -85 °C
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  5 min

Reference

Scalable and Straightforward Synthesis of All Isomeric (Cyclo)alkylpiperidines

Subota, Andrii I.; Lutsenko, Anton O.; Vashchenko, Bohdan V.; Volochnyuk, Dmitriy M.; Levchenko, Vitalina; et al, European Journal of Organic Chemistry, 2019, 2019(22), 3636-3648

Production Method 2

1191-95-3

626-55-1

889687-37-0

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ;  20 min, rt → -85 °C; 25 min, 25 °C
1.2 Solvents: Tetrahydrofuran ;  15 min, -85 °C; -85 °C → rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

Synthesis of Dihydropyridine Spirocycles by Semi-Pinacol-Driven Dearomatization of Pyridines

Abell, Joseph C. ; Bold, Christian P. ; Vicens, Laia; Jentsch, Tom; Perez, Noelia Velasco; et al, Organic Letters, 2023, 25(2), 400-404

1-(3-Bromopyridin-4-yl)cyclobutanol Raw materials

• Cyclobutanone
• 3-Bromopyridine

1-(3-Bromopyridin-4-yl)cyclobutanol Preparation Products

• 1-(3-Bromopyridin-4-yl)cyclobutanol (889687-37-0)

• 1. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 2. An amorphous Cu–In–S nanoparticle-based precursor ink with improved atom economy for CuInSe2 solar cells with 10.85% efficiency?
  Green Chem., 2017,19, 1268-1277
• 3. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 4. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 5. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279

• 494802-14-1(Cyclohexanecarbonitrile, 4-(3-bromo-4-pyridinyl)-4-hydroxy-, trans-)
• 1404119-74-9(1-(3-Bromo-pyridin-4-yl)-cyclopentanol)
• 1255713-79-1(3-Bromo-4-(oxetan-2-YL)pyridine)
• 1932164-55-0((1R)-1-(3-bromopyridin-4-yl)ethan-1-ol)
• 1240605-46-2(2-(3-bromo-4-pyridyl)propan-2-ol)
• 2089245-40-7((1S)-1-(3-bromopyridin-4-yl)ethan-1-ol hydrochloride)
• 1782495-28-6(4-Pyridinemethanol, α-(2-aminoethyl)-3-bromo-)
• 494802-07-2(Cyclohexanone, 4-(3-bromo-4-pyridinyl)-4-hydroxy-)
• 149227-04-3(1-(3-Bromopyridin-4-yl)ethanol)
• 1932441-50-3((1S)-1-(3-Bromopyridin-4-yl)ethan-1-ol)