Cas no 1782495-28-6 (4-Pyridinemethanol, α-(2-aminoethyl)-3-bromo-)

4-Pyridinemethanol, α-(2-aminoethyl)-3-bromo-, is a brominated pyridine derivative featuring both hydroxyl and aminoethyl functional groups, making it a versatile intermediate in organic synthesis and pharmaceutical applications. The presence of the 3-bromo substituent enhances its reactivity for cross-coupling reactions, such as Suzuki or Buchwald-Hartwig couplings, while the aminoethyl side chain provides a handle for further derivatization. This compound is particularly useful in the development of bioactive molecules, ligands, and catalysts due to its bifunctional reactivity. Its structural features enable precise modifications, facilitating the synthesis of complex heterocyclic frameworks. Suitable for controlled reactions, it offers high selectivity and efficiency in targeted synthetic pathways.
4-Pyridinemethanol, α-(2-aminoethyl)-3-bromo- structure
1782495-28-6 structure
Product Name:4-Pyridinemethanol, α-(2-aminoethyl)-3-bromo-
CAS No:1782495-28-6
MF:C8H11BrN2O
MW:231.089740991592
CID:5275956
PubChem ID:84694203
Update Time:2025-05-22

4-Pyridinemethanol, α-(2-aminoethyl)-3-bromo- Chemical and Physical Properties

Names and Identifiers

    • 4-Pyridinemethanol, α-(2-aminoethyl)-3-bromo-
    • 1782495-28-6
    • 3-amino-1-(3-bromopyridin-4-yl)propan-1-ol
    • EN300-683576
    • Inchi: 1S/C8H11BrN2O/c9-7-5-11-4-2-6(7)8(12)1-3-10/h2,4-5,8,12H,1,3,10H2
    • InChI Key: RCCFIPWPKCZDHU-UHFFFAOYSA-N
    • SMILES: BrC1C=NC=CC=1C(CCN)O

Computed Properties

  • Exact Mass: 230.00548g/mol
  • Monoisotopic Mass: 230.00548g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 3
  • Complexity: 134
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.1
  • Topological Polar Surface Area: 59.1?2

Experimental Properties

  • Density: 1.539±0.06 g/cm3(Predicted)
  • Boiling Point: 377.7±42.0 °C(Predicted)
  • pka: 12.50±0.20(Predicted)

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Additional information on 4-Pyridinemethanol, α-(2-aminoethyl)-3-bromo-

Recent Advances in the Study of 4-Pyridinemethanol, α-(2-aminoethyl)-3-bromo- (CAS: 1782495-28-6)

The compound 4-Pyridinemethanol, α-(2-aminoethyl)-3-bromo- (CAS: 1782495-28-6) has recently garnered significant attention in the field of chemical biology and medicinal chemistry due to its potential applications in drug discovery and development. This research briefing aims to provide an overview of the latest findings related to this compound, focusing on its synthesis, biological activity, and therapeutic potential.

Recent studies have highlighted the unique structural features of 4-Pyridinemethanol, α-(2-aminoethyl)-3-bromo-, which make it a promising candidate for targeting specific biological pathways. The presence of the bromo-substituent at the 3-position and the aminoethyl side chain at the α-position of the pyridine ring contribute to its ability to interact with various enzymes and receptors. Researchers have employed advanced synthetic techniques, including multi-step organic synthesis and catalysis, to optimize the production of this compound with high purity and yield.

In vitro and in vivo studies have demonstrated the compound's efficacy in modulating key cellular processes. For instance, it has shown inhibitory activity against certain kinases involved in inflammatory and oncogenic pathways. These findings suggest potential applications in the treatment of diseases such as cancer and autoimmune disorders. Additionally, the compound's ability to cross the blood-brain barrier has sparked interest in its use for neurological conditions.

Further investigations into the mechanism of action of 4-Pyridinemethanol, α-(2-aminoethyl)-3-bromo- have revealed its role in disrupting protein-protein interactions critical for disease progression. Structural-activity relationship (SAR) studies are ongoing to identify derivatives with enhanced potency and selectivity. Collaborative efforts between academic institutions and pharmaceutical companies are accelerating the translation of these discoveries into preclinical candidates.

In conclusion, the compound 4-Pyridinemethanol, α-(2-aminoethyl)-3-bromo- (CAS: 1782495-28-6) represents a promising scaffold for the development of novel therapeutics. Continued research into its biological properties and optimization of its chemical structure will be essential for realizing its full potential in medicine. Future studies should focus on addressing challenges related to pharmacokinetics and toxicity to facilitate its progression into clinical trials.

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