Production Method 1

1603-41-4

122-00-9

88965-00-8

Reaction Conditions

1.1 Reagents: Bromine Catalysts: Aluminum chloride Solvents: Methanol ;  0 - 5 °C; 30 min, 0 - 5 °C
1.2 Reagents: Sodium carbonate Solvents: Water ;  25 - 35 °C

Reference

Microwave-assisted synthesis of Imidazo[1,2-a]pyridine derivatives and their anti-inflammatory activity

Budumuru, Pushpalatha; Golagani, Srinivasarao; Pushpanjali, B., International Journal of Pharmaceutical Sciences and Research, 2019, 10(3), 1172-1179

Production Method 2

1603-41-4

122-00-9

88965-00-8

Reaction Conditions

1.1 Reagents: Bromine Catalysts: Aluminum chloride Solvents: Methanol ;  0 - 5 °C; 30 min, 0 - 5 °C
1.2 Reagents: Sodium carbonate ,  Water ;  25 - 35 °C

Reference

A simple, efficient and scalable synthesis of hypnotic agent, zolpidem

Sumalatha, Yasareni; Reddy, Tamma Ranga; Reddy, Padi Pratap; Satyanarayana, Bollikonda, ARKIVOC (Gainesville, 2008, (2), 315-320

Production Method 3

1603-41-4

619-41-0

88965-00-8

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Ethanol ;  6 h, rt

Reference

Iodide-Catalyzed Phosphorothiolation of Heteroarenes Using P(O)H Compounds and Elemental Sulfur

Shi, Shanshan; Chen, Jun; Zhuo, Shaohua; Wu, Zi'ang; Fang, Meijuan; et al, Advanced Synthesis & Catalysis, 2019, 361(13), 3210-3216

Production Method 4

1603-41-4

122-00-9

88965-00-8

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Sodium dodecyl sulfate ,  Iodine Solvents: Water ;  12 h, 40 °C

Reference

Iodine Promoted Efficient Synthesis of 2-Arylimidazo[1,2-a]pyridines in Aqueous Media: A Comparative Study between Micellar Catalysis and an "On-Water" Platform

Bhutia, Zigmee T.; Panjikar, Padmini C.; Iyer, Shruti; Chatterjee, Amrita ; Banerjee, Mainak, ACS Omega, 2020, 5(22), 13333-13343

Production Method 5

1603-41-4

122-00-9

88965-00-8

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Cuprous iodide ,  Indium triflate Solvents: N-Methyl-2-pyrrolidone ;  30 h, 1 atm, 100 °C

Reference

CuI-Catalyzed Aerobic Oxidative α-Amination Cyclization of Ketones to Access Aryl or Alkenyl-Substituted Imidazoheterocycles

Zhang, Yuanfei; Chen, Zhengkai; Wu, Wenliang; Zhang, Yuhong; Su, Weiping, Journal of Organic Chemistry, 2013, 78(24), 12494-12504

Production Method 6

1603-41-4

122-00-9

88965-00-8

Reaction Conditions

1.1 Reagents: Potassium iodide Catalysts: Trifluoromethanesulfonic acid Solvents: Ethanol ,  Dimethyl sulfoxide ;  15 h, 80 °C

Reference

Solvent-dependence of KI Mediated Electrosynthesis of Imidazo[1,2-a]pyridines

Yi, Yangjie; Xu, Leitao; Liu, Yuyang; Li, Mingfang; Zhang, Lijuan; et al, Chemical Research in Chinese Universities, 2023, 39(2), 318-324

Production Method 7

1603-41-4

122-00-9

88965-00-8

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Iodine ,  Benzo[g]pteridinium, 5-ethyl-1,3,7,8-tetramethyl-2,4-dioxo-, 1,1,1-trifluorometh… Solvents: Ethyl acetate ;  24 h, 70 °C

Reference

Multicomponent Synthesis of Imidazo[1,2-a]pyridines: Aerobic Oxidative Formation of C-N and C-S Bonds by Flavin-Iodine-Coupled Organocatalysis

Okai, Hayaki; Tanimoto, Kazumasa; Ohkado, Ryoma; Iida, Hiroki, Organic Letters, 2020, 22(20), 8002-8006

Production Method 8

1603-41-4

122-00-9

88965-00-8

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Boron trifluoride etherate ,  Cuprous iodide Solvents: Water ;  24 h, 60 - 65 °C

Reference

Copper(I) Iodide Catalyzed Aerobic Oxidative C-N and C-S bond formations through C-H Activation: Synthesis of Functionalized Imidazo[1,2-a]pyridines

Mohan, Darapaneni Chandra; Rao, Sadu Nageswara; Ravi, Chitrakar; Adimurthy, Subbarayappa, Asian Journal of Organic Chemistry, 2014, 3(5), 609-613

Production Method 9

1603-41-4

619-41-0

88965-00-8

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Methanol ;  rt; 12 h, reflux

Reference

Synthesis and Structure-Activity Relationships of Imidazopyridine/Pyrimidine- and Furopyridine-Based Anti-infective Agents against Trypanosomiases

Silva, Daniel G. ; Junker, Anna ; de Melo, Shaiani M. G.; Fumagalli, Fernando ; Gillespie, J. Robert ; et al, ChemMedChem, 2021, 16(6), 966-975

Production Method 10

1603-41-4

619-41-0

88965-00-8

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Ethanol ;  6 h, rt

Reference

Formation of Methylene Linkage for N-Heterocycles: Sequential C-H and C-O Bond Functionalization of Methanol with Cosolvent Water

Li, Na; Bai, Jinku; Zheng, Xiaolin; Rao, Honghua, Journal of Organic Chemistry, 2019, 84(11), 6928-6939

Production Method 11

1603-41-4

619-41-0

88965-00-8

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Ethanol ;  6 h, rt

Reference

Iron-Catalyzed Dehydrogenative sp3-sp2 Coupling via Direct Oxidative C-H Activation of Acetonitrile

Su, Huimin; Wang, Luyao; Rao, Honghua ; Xu, Hao, Organic Letters, 2017, 19(9), 2226-2229

Production Method 12

1603-41-4

122-00-9

88965-00-8

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Water ,  Polyethylene glycol ;  35 min, 85 °C

Reference

Efficient and green microwave-assisted one-pot synthesis of azaindolizines in PEG-400 and water

Wagare, Devendra S.; Farooqui, Mazhar; Keche, Tushar D.; Durrani, Ayesha, Synthetic Communications, 2016, 46(21), 1741-1746

Production Method 13

1603-41-4

2227-58-9

88965-00-8

Reaction Conditions

1.1 Reagents: Potassium acetate ,  Silver carbonate Solvents: 1,4-Dioxane ;  12 h, 110 °C

Reference

Ag(I)-Promoted Decarboxylative Annulation of Alkynoic Acids towards 2-Arylimidazo[1,2-a]pyridines

Liu, Yun ; Wang, Ziqing; Lei, Ting; Li, Yuling, ChemistrySelect, 2022, 7(47),

Production Method 14

98475-04-8

1603-41-4

88965-00-8

Reaction Conditions

1.1 Reagents: β-Cyclodextrin Solvents: Water ;  50 - 55 °C; 5 min, 50 - 55 °C
1.2 18 min, 50 - 55 °C

Reference

Aqueous phase synthesis of substituted imidazo[1,2-a]pyridine in the presence of β-cyclodextrin

Kumbhar, Vijay V.; Hangirgekar, Shankar P.; Wadwale, Navanand B., Pharma Chemica, 2013, 5(5), 274-279

Production Method 15

1603-41-4

122-00-9

88965-00-8

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Cuprous iodide Solvents: 1,4-Dioxane ;  14 h, 100 °C

Reference

Copper catalyzed tandem oxidative C-H amination/cyclizations: Direct access to imidazo[1,2-a]pyridines

Pericherla, Kasiviswanadharaju; Kaswan, Pinku; Khedar, Poonam; Khungar, Bharti; Parang, Keykavous; et al, RSC Advances, 2013, 3(41), 18923-18930

Production Method 16

1603-41-4

122-00-9

88965-00-8

Reaction Conditions

1.1 Catalysts: Cuprous iodide Solvents: 1,4-Dioxane ;  4 h, 100 °C

Reference

Rhodium(II)-Catalyzed Regioselective C3-Alkylation of 2-Arylimidazo[1,2-a]pyridines with Aryl Diazoesters

Kim, Hyunseok; Byeon, Minhyeon; Jeong, Eunchong; Baek, Yonghyeon; Jeong, Seung Jin; et al, Advanced Synthesis & Catalysis, 2019, 361(9), 2094-2106

Production Method 17

1603-41-4

122-00-9

88965-00-8

Reaction Conditions

Reference

Synthesis and antiproliferative activity evaluation of steroidal imidazo[1,2-a]pyridines

Rassokhina, Irina V.; Volkova, Yulia A.; Kozlov, Andrey S.; Scherbakov, Alexander M.; Andreeva, Olga E.; et al, Steroids, 2016, 113, 29-37

6-methyl-2-(4-methylphenyl)imidazo1,2-apyridine Raw materials

• Ethanone, 1-(4-methylphenyl)-2-[[(4-methylphenyl)sulfonyl]oxy]-
• 5-methylpyridin-2-amine
• 3-(4-methylphenyl)prop-2-ynoic Acid
• 4'-Methylacetophenone
• 2-bromo-1-(p-tolyl)ethan-1-one

6-methyl-2-(4-methylphenyl)imidazo1,2-apyridine Preparation Products

• 6-methyl-2-(4-methylphenyl)imidazo1,2-apyridine (88965-00-8)

• 1. An investigation of new infrared nonlinear optical material: BaCdSnSe4, and three new related centrosymmetric compounds: Ba2SnSe4, Mg2GeSe4, and Ba2Ge2S6?
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• 2. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 3. Alt-proteins: A promising future
• 4. An integrated microfluidic 3D tumor system for parallel and high-throughput chemotherapy evaluation?
  Dan Liu,Rui Hu,Zhongchao Huang,Meilin Sun,Kai Han Analyst, 2020,145, 6447-6455
• 5. An approach to biodegradable star polymeric architectures using disulfide coupling?
  Jingquan Liu,Huiyun Liu,Zhongfan Jia,Volga Bulmus,Thomas P. Davis Chem. Commun., 2008, 6582-6584

• 4105-21-9(2-phenylimidazo1,2-apyridine)
• 475992-43-9(2-(3-methylphenyl)-Imidazo[1,2-a]pyridine)
• 1019-89-2(6-methyl-2-phenylimidazo[1,2-a]pyridine)
• 3323-66-8(Imidazo[1,2-a]pyridine,2-phenyl-, hydrobromide (1:1))
• 65964-60-5(2-(4-methylphenyl)imidazo[1,2-a]pyridine)
• 1338248-70-6(6-methyl-3-phenyl-Imidazo[1,2-a]pyridine)
• 177962-27-5(8-methyl-3-phenyl-Imidazo[1,2-a]pyridine)
• 75318-68-2(Imidazo[2,1-a]isoquinoline, 2-[1,1'-biphenyl]-4-yl-)
• 70845-68-0(Imidazo[2,1-a]isoquinoline,2-phenyl-)
• 885-89-2(8-methyl-2-phenylimidazo1,2-apyridine)