Production Method 1

129722-34-5

889443-20-3

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Dichloromethane ,  Water ;  30 - 45 min, 25 - 35 °C
1.2 Solvents: Methanol ;  50 - 60 °C

Reference

Synthesis and characterization of N-oxides and metabolites of anti-psychotic drug, aripiprazole

Satyanarayana, Bollikonda; Sumalatha, Yasareni; Kumar, Sythana Suresh; Venkatraman, Sundaram; Reddy, Ghanta Mahesh; et al, Heterocyclic Communications, 2005, 11(6), 485-490

Production Method 2

33036-62-3

22246-18-0

889443-20-3

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  10 h, reflux

Reference

Synthesis of aripiprazole

Zhao, Huiqing; Feng, Tingmei; Wu, Qiuye; Liao, Hongli, Zhongguo Yiyao Gongye Zazhi, 2006, 37(9), 580-581

Production Method 3

2370959-16-1

889443-20-3

Reaction Conditions

1.1 Reagents: Zinc chloride Solvents: Tetrahydrofuran ;  4 h, rt

Reference

The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D3 Receptor (D3R) Selective Agonists

Battiti, Francisco O.; Cemaj, Sophie L.; Guerrero, Adrian M.; Shaik, Anver Basha; Lam, Jenny; et al, Journal of Medicinal Chemistry, 2019, 62(13), 6287-6314

3,4-Dihydro-7-(4-hydroxybutoxy)-2(1H)-quinolinone Raw materials

• 7-(4-bromobutoxy)-1,2,3,4-tetrahydroquinolin-2-one
• 4-Bromo-1-butanol (contains varying amounts of THF)
• 3,4-Dihydro-7-hydroxyquinoline-2(1H)-one
• 7-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]butoxy]-3,4-dihydro-2(1H)-quinolinone

3,4-Dihydro-7-(4-hydroxybutoxy)-2(1H)-quinolinone Preparation Products

• 3,4-Dihydro-7-(4-hydroxybutoxy)-2(1H)-quinolinone (889443-20-3)

• 1. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 2. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 3. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 4. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 5. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Hydroquinolones
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Quinolones and derivatives Hydroquinolones

• 92-79-5(3-hydroxy-4'-methoxy-2-naphthanilide)
• 97-36-9(2,4-Dimethylacetoacetanilide)
• 62-44-2(Phenacetin)
• 22246-17-9(7-Methoxy-3,4-dihydroquinolin-2(1H)-one)
• 882880-12-8(1,4-Bis3,4-dihydro-2(1H)-quinolinon-7-oxybutane)
• 51-66-1(N-(4-Methoxyphenyl)acetamide)
• 59-48-3(Oxindole)
• 92-15-9(o-Acetoacetanisidide)
• 93-68-5(N-(2-methylphenyl)-3-oxobutanamide)
• 59-06-3(Ethopabate)