Production Method 1

785777-87-9

887626-20-2

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Toluene ,  Hexane ;  15 min, -90 °C
1.2 -
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1, rt

Reference

Metal-bearing and trifluoromethyl-substituted pyrimidines: generation and functionalization

Schlosser, Manfred; Lefebvre, Olivier; Ondi, Levente, European Journal of Organic Chemistry, 2006, (6), 1593-1598

Production Method 2

2926-29-6

34253-03-7

887626-20-2

1260664-64-9

Reaction Conditions

1.1 Reagents: tert-Butyl hydroperoxide Solvents: Dichloromethane ,  Water ;  0 °C; 0 °C → 23 °C; 40 h, 23 °C

Reference

Innate C-H trifluoromethylation of heterocycles

Ji, Yining; Brueckl, Tobias; Baxter, Ryan D.; Fujiwara, Yuta; Seiple, Ian B.; et al, Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(35), 14411-14415

Methyl 4-(trifluoromethyl)pyrimidine-2-carboxylate Raw materials

• Sodium Triflinate
• Methyl pyrimidine-2-carboxylate
• 2-Bromo-4-(trifluoromethyl)pyrimidine

Methyl 4-(trifluoromethyl)pyrimidine-2-carboxylate Preparation Products

• Methyl 4-(trifluoromethyl)pyrimidine-2-carboxylate (887626-20-2)
• Methyl 5-(trifluoromethyl)pyrimidine-2-carboxylate (1260664-64-9)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Pyrimidinecarboxylic acids and derivatives

• 561322-46-1(2-PYRIMIDINECARBOXYLIC ACID, 5-AMINO-4-(TRIFLUOROMETHYL)-, ETHYL ESTER)
• 1353101-38-8(Methyl 6-(trifluoromethyl)pyrimidine-4-carboxylate)
• 1333222-31-3((4-(Trifluoromethyl)pyrimidin-2-yl)methyl acetate)
• 1346808-72-7(2,2'-(Oxybis(methylene))bis(4-(trifluoromethyl)pyrimidine))
• 317334-58-0(Methyl 4-methylpyrimidine-2-carboxylate)
• 1782555-45-6(4-(Difluoromethyl)pyrimidine-2-carboxylic acid)
• 1355729-56-4(Methyl 4-(difluoromethyl)pyrimidine-2-carboxylate)
• 1379313-04-8(4-methyl-6-(trifluoromethyl)pyrimidine-2-carboxylic acid)
• 878745-51-8(Methyl 2-(trifluoromethyl)pyrimidine-4-carboxylate)
• 1000931-46-3(4-(Trifluoromethyl)pyrimidine-2-carboxylic acid)