Comprehensive Overview of 4-Bromo-1H-indazol-6-amine (CAS No. 885518-53-6): Properties, Applications, and Research Insights
4-Bromo-1H-indazol-6-amine (CAS No. 885518-53-6) is a high-value brominated indazole derivative widely recognized for its versatile applications in pharmaceutical research and organic synthesis. This compound belongs to the heterocyclic amine family, characterized by a bromine substituent at the 4-position and an amino group at the 6-position of the indazole scaffold. Its unique structural features make it a critical intermediate in the development of kinase inhibitors, anticancer agents, and other bioactive molecules. Researchers and industry professionals frequently search for terms like "4-Bromo-1H-indazol-6-amine synthesis," "CAS 885518-53-6 suppliers," and "indazole derivatives in drug discovery," reflecting its growing relevance in modern chemistry.
The molecular formula of 4-Bromo-1H-indazol-6-amine is C7H6BrN3, with a molecular weight of 212.05 g/mol. Its physicochemical properties, such as solubility in polar organic solvents and stability under controlled conditions, have been extensively documented. Recent studies highlight its role in medicinal chemistry, particularly in the design of targeted therapies for oncology and inflammatory diseases. The compound's structure-activity relationship (SAR) has attracted attention due to its ability to modulate key biological pathways, aligning with trending topics like "precision medicine" and "small-molecule drug development."
In synthetic chemistry, 4-Bromo-1H-indazol-6-amine serves as a pivotal building block for cross-coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig couplings. These transformations enable the introduction of diverse functional groups, expanding its utility in high-throughput screening libraries. Notably, the compound's bromine atom offers a reactive site for further derivatization, a feature often explored in "fragment-based drug design"—a hot topic in AI-driven drug discovery platforms. Researchers also investigate its potential in photocatalysis and metal-organic frameworks (MOFs), addressing sustainability trends in chemical synthesis.
Quality control of CAS No. 885518-53-6 involves advanced analytical techniques such as HPLC, NMR spectroscopy, and mass spectrometry. Purity standards (>98%) are crucial for reproducible results in biological assays, a concern frequently raised in forums discussing "reagent-grade chemicals for research." Storage recommendations typically include protection from light and moisture at -20°C, ensuring long-term stability—a detail highly sought after by laboratory managers optimizing compound storage protocols.
Emerging applications of 4-Bromo-1H-indazol-6-amine extend to material science, where its conjugated system contributes to the development of organic semiconductors. This interdisciplinary potential resonates with searches for "indazole-based functional materials" and "electronic device components." Furthermore, its metabolite profiling in pharmacokinetic studies aligns with the pharmaceutical industry's focus on "ADME properties optimization," a key phrase in current literature.
Regulatory compliance for 885518-53-6 follows standard laboratory chemical guidelines, with proper handling under fume hoods recommended. While not classified as hazardous under major chemical inventories, its use requires standard personal protective equipment (PPE)—a topic frequently addressed in workplace safety trainings and "chemical handling best practices" webinars. The compound's Safety Data Sheet (SDS) provides detailed handling instructions, a document commonly requested by procurement specialists.
Market availability of 4-Bromo-1H-indazol-6-amine spans specialized chemical suppliers and contract research organizations (CROs). Pricing trends correlate with demand from biotech startups and academic institutions, as reflected in searches for "bulk indazole derivatives pricing." Custom synthesis services offering isotope-labeled versions (e.g., 15N or 13C) cater to advanced tracer studies, tapping into the growing "proteomics research tools" market segment.
Future research directions for this compound may explore its computational chemistry parameters using molecular docking simulations—a technique gaining traction in "AI-assisted drug discovery" discussions. Comparative studies with analogous halogenated indazoles could further elucidate its selectivity profiles, addressing frequent queries about "structure-based drug design strategies." As the scientific community emphasizes green chemistry principles, novel synthetic routes for 885518-53-6 using catalytic methods may emerge, aligning with "environmentally friendly synthesis" search trends.
