Production Method 1

473416-12-5

885271-25-0

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Iodine Solvents: Dimethylformamide ;  0 °C

Reference

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)acetamides and carboxamides

Laufer, Radoslaw ; Ng, Grace; Liu, Yong; Patel, Narendra Kumar B.; Edwards, Louise G.; et al, Bioorganic & Medicinal Chemistry, 2014, 22(17), 4968-4997

Production Method 2

473416-12-5

885271-25-0

Reaction Conditions

1.1 Reagents: Potassium hydroxide ,  Iodine Solvents: Dimethyl sulfoxide ;  4 h, rt
1.2 Reagents: Sodium bisulfite

Reference

Kemp-type elimination of 1-arylsulfonyl-3-iodo-1H-indazoles

Zhang, Jiawei; Kong, Kaimin; Li, Xiangjun; Zhang, Qian, Synthetic Communications, 2021, 51(15), 2365-2376

Production Method 3

473416-12-5

885271-25-0

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Iodine Solvents: Dimethylformamide ;  overnight, rt
1.2 Reagents: Sodium thiosulfate Solvents: Water ;  rt

Reference

Design, synthesis, and Structure-Activity Relationships (SAR) of 3-vinylindazole derivatives as new selective tropomyosin receptor kinases (Trk) inhibitors

Duan, Yunxin; Wang, Jie; Zhu, Sihua; Tu, Zheng-Chao; Zhang, Zhang; et al, European Journal of Medicinal Chemistry, 2020, 203,

Production Method 4

473416-12-5

885271-25-0

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Iodine Solvents: Dimethylformamide ;  > 1 h, 0 °C

Reference

Preparation of 3-indazolylbenzenesulfonamides as kinase inhibitors useful in treating cancer

, World Intellectual Property Organization, , ,

Production Method 5

473416-12-5

885271-25-0

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Iodine Solvents: Dimethylformamide ;  rt; 15 h, rt
1.2 Reagents: Sodium bisulfite Solvents: Water ;  rt; 1 h, rt

Reference

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting

Huard, Kim; Smith, Aaron C.; Cappon, Gregg; Dow, Robert L. ; Edmonds, David J. ; et al, Journal of Medicinal Chemistry, 2020, 63(19), 10879-10896

Methyl 3-iodo-1H-indazole-5-carboxylate Raw materials

• Methyl 1H-Indazole-5-carboxylate

Methyl 3-iodo-1H-indazole-5-carboxylate Preparation Products

• Methyl 3-iodo-1H-indazole-5-carboxylate (885271-25-0)

• 1. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 2. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 3. Fe3O4/FeS2 heterostructures enable efficient oxygen evolution reaction?
  Xingqun Zheng,Lele Song,Xin Feng,Li Li,Zidong Wei J. Mater. Chem. A, 2020,8, 14145-14151
• 4. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 5. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzopyrazoles Indazoles

• 1086391-11-8(3-Iodo-1H-indazole-6-carboxylic acid)
• 885519-74-4(Methyl 6-iodo-1H-indazole-4-carboxylate)
• 885519-33-5(Methyl 4-iodo-1H-indazole-6-carboxylate)
• 944899-05-2(Methyl 3-iodo-1H-indazole-7-carboxylate)
• 885521-35-7(Methyl 4-fluoro-3-iodo-1H-indazole-6-carboxylate)
• 885518-82-1(Methyl 3-iodo-1H-indazole-6-carboxylate)
• 885521-81-3(Methyl 6-fluoro-3-iodo-1H-indazole-4-carboxylate)
• 885521-05-1(Methyl 4-amino-3-iodo-1H-indazole-6-carboxylate)
• 885523-89-7(methyl 6-bromo-3-iodo-1H-indazole-4-carboxylate)
• 885520-80-9(3-Iodo-1H-indazole-4-carboxylic acid)