• 1. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 2. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 4. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 5. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400

Methyl 4-fluoro-3-iodo-1H-indazole-6-carboxylate: A Comprehensive Overview

Methyl 4-fluoro-3-iodo-1H-indazole-6-carboxylate, identified by the CAS number 885521-35-7, is a compound of significant interest in the fields of organic chemistry and pharmacology. This compound belongs to the indazole derivative family, which has been extensively studied for its potential applications in drug discovery and materials science. The structure of Methyl 4-fluoro-3-iodo-1H-indazole-6-carboxylate consists of an indazole ring system with substituents at positions 4 and 3, namely a fluorine atom and an iodine atom, respectively. The carboxylate group at position 6 is methylated, adding to the compound's functional diversity.

Recent advancements in synthetic chemistry have enabled the efficient synthesis of Methyl 4-fluoro-3-iodo-1H-indazole-6-carboxylate. Researchers have employed various methodologies, including microwave-assisted synthesis and catalytic cross-coupling reactions, to optimize its production. These techniques not only enhance yield but also improve the purity of the compound, making it more suitable for downstream applications.

The unique combination of substituents in Methyl 4-fluoro-3-iodo-1H-indazole-6-carboxylate imparts distinctive electronic and steric properties to the molecule. The fluorine atom at position 4 contributes to electronic withdrawing effects, while the iodine atom at position 3 introduces significant steric hindrance. These features make the compound a valuable building block in medicinal chemistry for designing bioactive molecules with specific pharmacokinetic profiles.

In terms of biological activity, studies have shown that Methyl 4-fluoro-3-iodo-1H-indazole-6-carboxylate exhibits promising anti-inflammatory and antioxidant properties. Preclinical trials have demonstrated its ability to inhibit pro-inflammatory cytokines and scavenge free radicals, suggesting potential applications in treating chronic inflammatory diseases such as arthritis and neurodegenerative disorders.

The methyl ester group at position 6 of the indazole ring plays a crucial role in modulating the compound's solubility and bioavailability. This functional group can be readily modified to tailor the compound's pharmacokinetic properties, making it a versatile platform for drug development. Recent research has explored the conversion of this ester group into other bioactive moieties, such as amides or phosphonates, to enhance therapeutic efficacy.

From a materials science perspective, Methyl 4-fluoro-3-iodeo-H-indazolee carboxylate has shown potential as a precursor for advanced materials such as organic semiconductors and light-emitting diodes (LEDs). Its electronic properties make it a candidate for applications in optoelectronic devices, where precise control over molecular structure is essential for achieving desired performance metrics.

In conclusion, Methyl 4-fluoro--iodes-H-indazol-e carboxylate stands out as a multifaceted compound with diverse applications across various scientific disciplines. Its unique chemical structure, coupled with recent advancements in synthesis and functionalization techniques, positions it as a key player in both academic research and industrial development. As ongoing studies continue to uncover new insights into its properties and applications, this compound is poised to make significant contributions to the advancement of science and technology.

• 1086391-11-8(3-Iodo-1H-indazole-6-carboxylic acid)
• 944899-05-2(Methyl 3-iodo-1H-indazole-7-carboxylate)
• 885518-82-1(Methyl 3-iodo-1H-indazole-6-carboxylate)
• 885521-81-3(Methyl 6-fluoro-3-iodo-1H-indazole-4-carboxylate)
• 885522-05-4(6-Fluoro-3-iodo-1H-indazole-4-carboxylic acid)
• 885521-54-0(Methyl 3-iodo-1H-indazole-4-carboxylate)
• 885521-44-8(Methyl 4-fluoro-1H-indazole-6-carboxylate)
• 885520-80-9(3-Iodo-1H-indazole-4-carboxylic acid)
• 697739-05-2(Methyl 6-fluoro-1H-indazole-4-carboxylate)
• 885271-25-0(Methyl 3-iodo-1H-indazole-5-carboxylate)