• 1. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 2. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 3. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 4. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 5. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
  Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives 2-halopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines 2-halopyridines

2-Chloro-4-methylpyridin-3-ol (CAS No. 884494-70-6): An Overview of a Promising Compound in Pharmaceutical Research

2-Chloro-4-methylpyridin-3-ol (CAS No. 884494-70-6) is a versatile organic compound that has garnered significant attention in the field of pharmaceutical research due to its unique chemical structure and potential biological activities. This compound, also known as 2-chloro-3-hydroxymethylpyridine, is characterized by a pyridine ring substituted with a chlorine atom at the 2-position and a methyl group at the 4-position, along with a hydroxyl group at the 3-position. The combination of these functional groups imparts distinct chemical and biological properties, making it an intriguing candidate for various applications.

The synthesis of 2-Chloro-4-methylpyridin-3-ol has been extensively studied, and several methods have been reported in the literature. One common approach involves the reaction of 3-hydroxypyridine with chloromethyl methyl ether followed by methylation. This method provides a high yield and purity, making it suitable for large-scale production. Recent advancements in synthetic chemistry have also explored greener and more sustainable methods, such as using catalytic systems and environmentally friendly solvents, to reduce the environmental impact of the synthesis process.

In terms of its physical and chemical properties, 2-Chloro-4-methylpyridin-3-ol is a white crystalline solid with a melting point of approximately 115°C. It is slightly soluble in water but highly soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO). These solubility characteristics are crucial for its use in various pharmaceutical formulations and biological assays.

The biological activity of 2-Chloro-4-methylpyridin-3-ol has been the subject of numerous studies, particularly in the context of its potential therapeutic applications. One area of significant interest is its role as an inhibitor of specific enzymes involved in metabolic pathways. For instance, research has shown that 2-Chloro-4-methylpyridin-3-ol can effectively inhibit certain kinases, which are key enzymes in signal transduction pathways associated with cancer and inflammatory diseases. This property makes it a promising lead compound for the development of novel therapeutic agents.

Beyond its enzymatic inhibition properties, 2-Chloro-4-methylpyridin-3-ol has also demonstrated antioxidant activity. Antioxidants play a crucial role in neutralizing free radicals and preventing oxidative stress, which is implicated in various diseases such as neurodegenerative disorders and cardiovascular diseases. Studies have indicated that 2-Chloro-4-methylpyridin-3-ol can scavenge reactive oxygen species (ROS) and protect cells from oxidative damage, suggesting its potential as a protective agent against oxidative stress-related conditions.

In addition to its direct biological effects, 2-Chloro-4-methylpyridin-3-ol has been explored as a building block for the synthesis of more complex molecules with enhanced biological activities. For example, it can be used as a precursor for the preparation of pyrazolo[1,5-a]pyrimidines, which have shown promise as potent inhibitors of protein kinases involved in cancer progression. The ability to modify the structure of 2-Chloro-4-methylpyridin-3-ol through functional group manipulation opens up numerous possibilities for the development of new drugs with improved pharmacological profiles.

The safety profile of 2-Chloro-4-methylpyridin-3-ol is another important aspect that has been investigated. Preclinical studies have shown that it exhibits low toxicity at therapeutic concentrations, making it a suitable candidate for further development. However, like any chemical compound, it is essential to conduct comprehensive safety evaluations to ensure its safe use in humans. Ongoing research aims to elucidate its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME), to optimize its use in therapeutic applications.

In conclusion, 2-Chloro-4-methylpyridin-3-ol (CAS No. 884494-70-6) is a multifaceted compound with significant potential in pharmaceutical research. Its unique chemical structure confers distinct biological activities that make it an attractive candidate for the development of novel therapeutic agents. Ongoing studies continue to explore its mechanisms of action and potential applications, highlighting its importance in advancing medical treatments for various diseases.

• 185423-26-1(2,6-Dichloro-3-hydroxypyridine-4-carboxaldehyde)
• 1227585-40-1(2-chloro-4-(chloromethyl)pyridin-3-ol)
• 1603251-89-3(2,6-dichloro-4-methylpyridin-3-ol)
• 1227592-02-0(2-Chloro-3-hydroxypyridine-4-acetonitrile)
• 1227502-89-7(6-chloro-4-Methylpyridin-3-ol)
• 1445968-07-9(2-chloro-5-hydroxypyridine-4-carbonitrile)
• 1227593-77-2(2-Chloro-5-methoxy-4-methylpyridine)
• 1196145-81-9(2-Chloro-3-hydroxyisonicotinaldehyde)
• 1060804-53-6(2-chloro-5-hydroxypyridine-4-carbaldehyde)
• 910649-59-1(2-Chloro-5-methylpyridin-3-ol)