• 1. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 2. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?
  Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139
• 3. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 4. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 5. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849

2-Chloro-5-Hydroxypyridine-4-Carbaldehyde: A Comprehensive Overview

2-Chloro-5-hydroxypyridine-4-carbaldehyde, also known by its CAS number 1060804-53-6, is a versatile organic compound with significant applications in various fields. This compound belongs to the class of pyridine derivatives, which are widely studied due to their unique chemical properties and potential uses in pharmaceuticals, agrochemicals, and materials science. The structure of this compound consists of a pyridine ring substituted with a chlorine atom at position 2, a hydroxyl group at position 5, and an aldehyde group at position 4. These substituents impart distinct reactivity and functionality to the molecule.

The synthesis of 2-chloro-5-hydroxypyridine-4-carbaldehyde typically involves multi-step organic reactions. Recent advancements in synthetic methodologies have enabled more efficient and selective routes to prepare this compound. For instance, researchers have explored the use of transition metal catalysts to facilitate key transformations, such as the formation of the pyridine ring or the introduction of functional groups. These developments have not only improved yield but also reduced the environmental footprint of the synthesis process.

The physical and chemical properties of 2-chloro-5-hydroxypyridine-4-carbaldehyde make it suitable for various applications. The presence of an aldehyde group allows for participation in condensation reactions, which are crucial in forming complex molecular architectures. Additionally, the hydroxyl group at position 5 can act as a nucleophilic site, enabling further functionalization. The chlorine atom at position 2 contributes to the compound's stability and reactivity under certain conditions.

In terms of biological activity, recent studies have highlighted the potential of 2-chloro-5-hydroxypyridine-4-carbaldehyde as a lead compound for drug discovery. Researchers have investigated its anti-inflammatory, antioxidant, and antimicrobial properties using advanced in vitro and in silico techniques. For example, computational modeling has revealed that this compound can interact with key protein targets associated with inflammatory diseases, suggesting its potential therapeutic applications.

The application of 2-chloro-5-hydroxypyridine-4-carbaldehyde extends beyond pharmacology into materials science. Its ability to form coordination complexes with metal ions has been exploited in the development of novel materials for sensing applications. Recent research demonstrates that this compound can serve as a sensing platform for detecting heavy metal ions in aqueous environments, offering a promising solution for environmental monitoring.

In conclusion, 2-chloro-5-hydroxypyridine-4-carbaldehyde, with its unique structure and diverse functional groups, continues to be a subject of intense research interest. Its synthesis methods are being refined for greater efficiency, while its biological and materials science applications are expanding rapidly. As new findings emerge from ongoing studies, this compound is poised to play an increasingly important role in both academic research and industrial applications.

• 1256807-90-5(methyl 2-chloro-5-hydroxypyridine-4-carboxylate)
• 185423-26-1(2,6-Dichloro-3-hydroxypyridine-4-carboxaldehyde)
• 1282516-32-8(2-Chloro-5-(methoxymethoxy)isonicotinaldehyde)
• 1227502-89-7(6-chloro-4-Methylpyridin-3-ol)
• 1445968-07-9(2-chloro-5-hydroxypyridine-4-carbonitrile)
• 185422-96-2(2,6-Dichloro-3-hydroxyisonicotinic acid)
• 185423-02-3(2-Chloro-3-hydroxyisonicotinic acid)
• 884494-70-6(2-Chloro-4-methylpyridin-3-ol)
• 1060801-70-8(2-chloro-5-methoxypyridine-4-carboxylic acid)
• 1060804-57-0(2-chloro-5-hydroxypyridine-4-carboxylic acid)