Production Method 1

3132-99-8

882772-99-8

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Nitric acid Solvents: Water ;  20 min, 0 °C; 1 h, rt

Reference

A stereoselective approach to peptidomimetic BACE1 inhibitors

Butini, Stefania; et al, European Journal of Medicinal Chemistry, 2013, 70, 233-247

Production Method 2

3132-99-8

882772-99-8

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Nitric acid Solvents: Water ;  40 min, < 10 °C; 30 min, 5 - 10 °C
1.2 Reagents: Water ;  cooled; 30 min, heated

Reference

Iron promoted C3-H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles

Murugan, Arumugavel; et al, Organic & Biomolecular Chemistry, 2018, 16(28), 5113-5118

Production Method 3

3132-99-8

882772-99-8

20357-20-4

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Potassium nitrate Solvents: Water ;  < 30 °C; 16 h, 23 °C

Reference

New octahydropyrido[3,4-b]acridine scaffolds for combinatorial chemistry

Diedrich, Claas Lueder; et al, Synthesis, 2008, (14), 2199-2210

Production Method 4

3132-99-8

882772-99-8

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Fuming nitric acid ;  20 min, 0 °C; 0 °C → rt; 12 h, 40 °C
1.2 Reagents: Water ;  0 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ;  pH 7

Reference

Benzimidazolyl Palladium Complexes as Highly Active and General Bifunctional Catalysts in Sustainable Cross-Coupling Reactions

Zhu, Jiancheng; et al, ACS Catalysis, 2019, 9(8), 6993-6998

Production Method 5

52414-97-8

882772-99-8

Reaction Conditions

1.1 Reagents: Pyrrolidine ,  Dimethylformamide dimethyl acetal ,  Sodium periodate Solvents: Dimethylformamide ,  Water

Reference

A Diels-Alder approach to biaryl synthesis

Ashburn, Bradley O., 2008, , 69(3),

Production Method 6

52414-97-8

882772-99-8

Reaction Conditions

1.1 Reagents: Pyrrolidine ,  Dimethylformamide dimethyl acetal Solvents: Dimethylformamide ;  rt; rt → 115 °C; 22 h, 115 °C; 115 °C → rt
1.2 Reagents: Sodium periodate Solvents: Dimethylformamide ,  Water ;  0 °C → rt; 3 h, rt

Reference

A Diels-Alder approach to biaryls (DAB): synthesis of the western portion of TMC-95

Ashburn, Bradley O.; et al, Tetrahedron, 2007, 64(5), 856-865

Production Method 7

52414-97-8

882772-99-8

Reaction Conditions

1.1 Reagents: Pyrrolidine ,  Dimethylformamide dimethyl acetal ;  22 h, 115 °C; 115 °C → 0 °C
1.2 Reagents: Sodium periodate Solvents: Dimethylformamide ,  Water ;  0 °C → rt

Reference

Design and Synthesis of a Novel Series of Bicyclic Heterocycles As Potent γ-Secretase Modulators

Bischoff, Francois; et al, Journal of Medicinal Chemistry, 2012, 55(21), 9089-9106

Production Method 8

552-89-6

882772-99-8

56990-05-7

20357-20-4

1559060-83-1

5551-12-2

20357-21-5

213382-42-4

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide ,  Sulfuric acid ;  3 h, rt
1.2 Reagents: Water ;  cooled

Reference

Reexamination of the Bromination of 2-Nitrobenzaldehyde with NBS or NaBr-NaIO4 in Sulfuric Acid

Cummings, Matthew M.; et al, Synthetic Communications, 2014, 44(7), 954-958

3-Bromo-2-nitrobenzaldehyde Raw materials

• 3-Bromobenzaldehyde
• 2-Nitrobenzaldehyde
• 1-bromo-3-methyl-2-nitro-benzene

3-Bromo-2-nitrobenzaldehyde Preparation Products

• 4,5-Dibromo-2-nitrobenzaldehyde (56990-05-7)
• 5-Bromo-2-nitrobenzaldehyde (20357-20-4)
• Benzaldehyde, 3,4-dibromo-2-nitro- (1559060-83-1)
• 3-Bromo-2-nitrobenzaldehyde (882772-99-8)
• 4-Bromo-2-nitrobenzaldehyde (5551-12-2)
• 2-Bromo-6-nitrobenzaldehyde (20357-21-5)
• Benzaldehyde, 3,6-dibromo-2-nitro- (213382-42-4)

• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 3. Excited-state proton-coupled electron transfer within ion pairs?
  Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473
• 4. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
  Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
• 5. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzenes Nitrobenzaldehydes

• 101682-68-2(3-Bromo-4-nitrobenzaldehyde)
• 414868-82-9(4-bromo-2-methyl-3-nitroaniline)
• 5411-53-0(5-Bromo-2,4-dinitrotoluene)
• 20357-20-4(5-Bromo-2-nitrobenzaldehyde)
• 78831-77-3(1-Bromo-3,5-dimethyl-2-nitrobenzene)
• 5551-12-2(4-Bromo-2-nitrobenzaldehyde)
• 52414-97-8(1-bromo-3-methyl-2-nitro-benzene)
• 116529-61-4(3-Bromo-2-nitrobenzoic acid)
• 56759-31-0(1-(3-Bromo-2-nitrophenyl)ethanone)
• 136833-29-9(5-BROMO-2,4-DINITROTOLUENE)