Production Method 1

443955-22-4

881658-92-0

Reaction Conditions

1.1 Reagents: Phosphorus tribromide Solvents: Dimethylformamide ;  1 h, 0 °C
1.2 Reagents: Sodium hydroxide Solvents: Water

Reference

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria

Kandepedu, Nishanth; et al, Journal of Medicinal Chemistry, 2018, 61(13), 5692-5703

Production Method 2

25063-69-8

881658-92-0

Reaction Conditions

1.1 Reagents: 1,1′-Biphenyl, mixt. with 1,1′-oxybis[benzene] ;  220 °C
2.1 Reagents: Phosphorus tribromide Solvents: Dimethylformamide ;  1 h, 0 °C
2.2 Reagents: Sodium hydroxide Solvents: Water

Reference

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria

Kandepedu, Nishanth; et al, Journal of Medicinal Chemistry, 2018, 61(13), 5692-5703

Production Method 3

2033-24-1

6628-77-9

881658-92-0

Reaction Conditions

1.1 Solvents: Ethanol ;  2 h, rt → 105 °C
1.2 12 h, 105 °C; 105 °C → rt
2.1 Reagents: 1,1′-Biphenyl, mixt. with 1,1′-oxybis[benzene] ;  220 °C
3.1 Reagents: Phosphorus tribromide Solvents: Dimethylformamide ;  1 h, 0 °C
3.2 Reagents: Sodium hydroxide Solvents: Water

Reference

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria

Kandepedu, Nishanth; et al, Journal of Medicinal Chemistry, 2018, 61(13), 5692-5703

8-Bromo-2-methoxy-1,5-naphthyridine Raw materials

• 2,2-dimethyl-1,3-dioxane-4,6-dione
• 6-methoxypyridin-3-amine
• 6-Methoxy-1,4-dihydro-1,5-naphthyridin-4-one
• 5-{(6-Methoxy-3-pyridinyl)aminomethylene}-2,2-dimethyl-1,3-dioxane-4,6-dione

8-Bromo-2-methoxy-1,5-naphthyridine Preparation Products

• 8-Bromo-2-methoxy-1,5-naphthyridine (881658-92-0)

• 1. An integrated microfluidic 3D tumor system for parallel and high-throughput chemotherapy evaluation?
  Dan Liu,Rui Hu,Zhongchao Huang,Meilin Sun,Kai Han Analyst, 2020,145, 6447-6455
• 2. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 3. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 4. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 5. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977

• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

• 1000341-07-0(3,6-Dibromo-5-methoxy-4-azaindole)
• 352434-16-3(3-Bromo-7-methoxy-1H-pyrrolo[2,3-c]pyridine)
• 13472-85-0(5-Bromo-2-methoxypyridine)
• 1003944-35-1(8-Bromo-2,7-dimethoxy-1,5-naphthyridine)
• 425380-37-6(4-Bromo-7-methoxy-1H-pyrrolo[2,3-c]pyridine)
• 1000341-09-2(3-Bromo-5-methoxy-1H-pyrrolo3,2-bpyridine)
• 13472-67-8(5-Bromo-2-methoxypyridine hydrochloride)
• 1204298-60-1(3-Bromo-5-methoxy-1H-pyrrolo[2,3-c]pyridine)
• 99455-08-0(7-Bromo-2-methoxyquinoline)
• 917474-63-6(8-Bromo-5-methoxy-1,6-naphthyridine)