Production Method 1

31181-74-5

88139-91-7

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Methanol ;  1 h, rt

Reference

End-On and Side-On Peroxo Derivatives of Non-Heme Iron Complexes with Pentadentate Ligands: Models for Putative Intermediates in Biological Iron/Dioxygen Chemistry

Roelfes, Gerard; et al, Inorganic Chemistry, 2003, 42(8), 2639-2653

Production Method 2

31181-64-3

88139-91-7

Reaction Conditions

1.1 Reagents: Trifluoroacetic anhydride ;  rt; 0.5 h, rt; 0.5 h, reflux
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  pH 8, rt; overnight, rt

Reference

Synthesis of a Non-Heme Template for Attaching Four Peptides: An Approach to Artificial Iron(II)-Containing Peroxidases

van den Heuvel, Marco; et al, Journal of Organic Chemistry, 2004, 69(2), 250-262

Production Method 3

31181-64-3

88139-91-7

Reaction Conditions

1.1 Reagents: Acetic anhydride ;  12 h, 90 °C
1.2 Reagents: Potassium hydroxide Solvents: Methanol ;  0 °C; 3 h, rt

Reference

Inhibition of 1-Deoxy-d-Xylulose-5-Phosphate Reductoisomerase by Lipophilic Phosphonates: SAR, QSAR, and Crystallographic Studies

Deng, Lisheng; et al, Journal of Medicinal Chemistry, 2011, 54(13), 4721-4734

Production Method 4

3430-13-5

88139-91-7

Reaction Conditions

1.1 Reagents: m-Chloroperbenzoic acid Solvents: Chloroform ;  5 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water
2.1 Reagents: Acetic anhydride ;  12 h, 90 °C
2.2 Reagents: Potassium hydroxide Solvents: Methanol ;  0 °C; 3 h, rt

Reference

Inhibition of 1-Deoxy-d-Xylulose-5-Phosphate Reductoisomerase by Lipophilic Phosphonates: SAR, QSAR, and Crystallographic Studies

Deng, Lisheng; et al, Journal of Medicinal Chemistry, 2011, 54(13), 4721-4734

Production Method 5

624-28-2

88139-91-7

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Toluene ,  Hexane ;  -78 °C; 2 h, -78 °C
1.2 1 h, -78 °C; -78 °C → rt
1.3 Reagents: Ammonium chloride Solvents: Water ;  rt
1.4 Reagents: Sodium borohydride Solvents: Methanol ;  rt; 1 h, rt
1.5 Reagents: Hydrochloric acid Solvents: Water ;  rt

Reference

Tetrameric Cyclic Double Helicates as a Scaffold for a Molecular Solomon Link

Beves, Jonathon E.; et al, Angewandte Chemie, 2013, 52(25), 6464-6467

Production Method 6

109-06-8

88139-91-7

Reaction Conditions

1.1 Reagents: Aluminum chloride ,  Bromine
1.2 Reagents: Hydrochloric acid
1.3 Reagents: Sodium bisulfite
2.1 Reagents: m-Chloroperbenzoic acid Solvents: Chloroform
3.1 Reagents: Trifluoroacetic anhydride
3.2 Reagents: Sodium bicarbonate Solvents: Water

Reference

Structure-activity relationships in the 2-arylcarbapenem series. Synthesis of 1-methyl-2-arylcarbapenems

Guthikonda, Ravindra Nath; et al, Journal of Medicinal Chemistry, 1987, 30(5), 871-80

Production Method 7

30766-11-1

88139-91-7

Reaction Conditions

1.1 Reagents: Triethylamine ,  Ethyl chloroformate Solvents: Tetrahydrofuran ;  0 °C
1.2 Reagents: Sodium borohydride Solvents: Water

Reference

Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase

De Schutter, Joris W.; et al, Bioorganic & Medicinal Chemistry Letters, 2010, 20(19), 5781-5786

Production Method 8

624-28-2

88139-91-7

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Toluene
1.2 -
1.3 Reagents: Sodium borohydride

Reference

Selective monolithiation of 2,5-dibromopyridine with butyllithium

Wang, Xin; et al, Tetrahedron Letters, 2000, 41(22), 4335-4338

Production Method 9

31181-64-3

88139-91-7

Reaction Conditions

1.1 Solvents: Acetic anhydride ;  overnight, 90 °C
1.2 Reagents: Sodium carbonate Solvents: Water ;  neutralized
2.1 Reagents: Potassium carbonate Solvents: Methanol ;  1 h, rt

Reference

End-On and Side-On Peroxo Derivatives of Non-Heme Iron Complexes with Pentadentate Ligands: Models for Putative Intermediates in Biological Iron/Dioxygen Chemistry

Roelfes, Gerard; et al, Inorganic Chemistry, 2003, 42(8), 2639-2653

5-Bromo-2-hydroxymethylpyridine Raw materials

• 5-Bromo-2-methylpyridine
• 2,5-Dibromopyridine
• 5-bromopyridine-2-carboxylic acid
• 2-Methylpyridine
• 5-bromo-2-Pyridinemethanol 2-acetate
• 5-Bromo-2-methyl-pyridine-1-oxide

5-Bromo-2-hydroxymethylpyridine Preparation Products

• 5-Bromo-2-hydroxymethylpyridine (88139-91-7)

• 1. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 2. An arsenic trioxide nanoparticle prodrug (ATONP) potentiates a therapeutic effect on an aggressive hepatocellular carcinoma model via enhancement of intratumoral arsenic accumulation and disturbance of the tumor microenvironment?
  Xin Fu,Qing-rong Liang,Rong-guang Luo,Yan-shu Li,Xiao-ping Xiao,Lu-lu Yu,Wen-zhe Shan,Guang-qin Fan J. Mater. Chem. B, 2019,7, 3088-3099
• 3. An AuNPs-functionalized AlGaN/GaN high electron mobility transistor sensor for ultrasensitive detection of TNT?
  Ying Li,Weirong Yao,Yunfei Xie,Renjun Pei RSC Adv., 2015,5, 98724-98729
• 4. Ambient electrochemical NH3 synthesis from N2 and water enabled by ZrO2 nanoparticles?
  Tong Xu,Dongwei Ma,Chengbo Li,Qian Liu,Siyu Lu,Abdullah M. Asiri,Chun Yang,Xuping Sun Chem. Commun., 2020,56, 3673-3676
• 5. Agricultural
  Analyst, 1947,72, 170-172

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives

• 245765-71-3((5-Bromo-3-methylpyridin-2-yl)methanol)
• 31181-82-5(2-Pyridinemethanol,5-bromo-, hydrochloride (1:1))
• 1227601-36-6((3,5-Dibromopyridin-2-yl)methanol)
• 773871-93-5((4-Bromo-1H-pyrrol-2-yl)methanol)
• 137778-11-1((5-bromo-6-methyl-2-pyridyl)methanol)
• 120491-88-5((4-Bromopyridine-2,6-diyl)dimethanol)
• 131747-45-0((4-Bromopyridin-2-yl)methanol)
• 52378-64-0((3-bromo-2-pyridyl)methanol)
• 1394291-59-8((5-Bromo-4-methylpyridin-2-yl)methanol)
• 448906-60-3((4-Bromo-6-methylpyridin-2-YL)methanol)