Cas no 88040-23-7 (Cefepime)

Cefepime structure
Cefepime structure
Product Name:Cefepime
CAS No:88040-23-7
MF:C19H24N6O5S2
MW:480.561060905457
MDL:MFCD00864890
CID:61134
PubChem ID:5479537
Update Time:2024-10-26

Cefepime Chemical and Physical Properties

Names and Identifiers

    • Cefepime
    • (6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-(Z)-(methoxyimino)acetamido]-3-[(1-methyl-1-pyrrolidinium)methyl]-3-cephem-4-carboxylate
    • 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(1-methylpyrrolidino)methyl-3-cephem-4-carboxylate
    • CEFEPIME ARGININE
    • Cefpim
    • CFPM
    • Tsefepim
    • [6R-[6alpha,7beta(Z)]]-1-[[7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methylpyrrolidinium hydroxide inner salt
    • cefipime
    • cefepime jp
    • fr 81335
    • Pyrrolidinium, 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-, inner salt (9CI)
    • Pyrrolidinium, 1-[[7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-, inner salt, [6R-[6α,7β(Z)]]- (ZCI)
    • BMY 28142
    • Cefimen K
    • Sefdin
    • UNII-807PW4VQE3
    • DB01413
    • BDBM50350470
    • D02376
    • AB01275446-01
    • Cefepimum [Latin]
    • Cefepime (USAN/INN)
    • HY-B0692
    • AS-76125
    • BCPP000292
    • CS-0009590
    • BCP9000504
    • J01DA24
    • AKOS015850865
    • C-2468
    • CEFEPIME [WHO-DD]
    • Maxipime
    • CHEMBL186
    • Cefepima [Spanish]
    • Renapime
    • HMS2089M18
    • C08111
    • BMY-28142
    • Cefepimum
    • Cefepime [USAN:INN:BAN]
    • AKOS016014147
    • 7beta-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(1-methylpyrrolidinium-1-yl)methyl]-3,4-didehydrocepham-4-carboxylate
    • 7beta-((2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido)-3-((1-methylpyrrolidinium-1-yl)methyl)-3,4-didehydrocepham-4-carboxylate
    • CEFEPIME [MI]
    • Pyrrolidinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-methyl-, hydroxide, inner salt, (6R-(6alpha,7beta(Z)))-
    • Cefepima
    • PYRROLIDINIUM, 1-((7-(((2-AMINO-4-THIAZOLYL)(METHOXYIMINO)ACETYL)AMINO)-2-CARBOXY-8-OXO-5-THIA-1-AZABICYCLO(4.2.0)OCT-2-EN-3-YL)METHYL)-1-METHYL-, HYDROXIDE, INNER SALT, (6R-(6.ALPHA.,7.BETA.(Z)))-
    • Cefepimum (Latin)
    • VNRX-5022
    • CHEBI:478164
    • Q27294816
    • J01DE01
    • CEFEPIME [USAN]
    • Cefepime, Antibiotic for Culture Media Use Only
    • 1-{[(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-2-carboxylato-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-methylpyrrolidin-1-ium
    • (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-[(1-methylpyrrolidinium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    • CEFEPIME [VANDF]
    • DTXCID20820707
    • Anticefepime (>90%)
    • SCHEMBL65720
    • 807PW4VQE3
    • CEFEPIME [INN]
    • 88040-23-7
    • (6R,7R)-7-(((2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl)amino)-3-((1-methylpyrrolidinium-1-yl)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate
    • 1-(((6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-methylpyrrolidinium hydroxide, inner salt, 7(sup 2)-(Z)-(O-methyloxime)
    • cefepim
    • (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    • DTXSID70873208
    • Cefepime EP Impurity A
    • DTXSID60164213
    • Axepim
    • 1-[[(6R,7R)-7-[[(2E)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-pyrrolidinium inner salt; Cefepime Impurity A; Cefepime EP Impurity A
    • MDL： MFCD00864890
    • Inchi： 1S/C19H24N6O5S2/c1-25(5-3-4-6-25)7-10-8-31-17-13(16(27)24(17)14(10)18(28)29)22-15(26)12(23-30-2)11-9-32-19(20)21-11/h9,13,17H,3-8H2,1-2H3,(H3-,20,21,22,26,28,29)/b23-12-/t13-,17-/m1/s1
    • InChI Key： HVFLCNVBZFFHBT-ZKDACBOMSA-N
    • SMILES： C(C1=C(C[N+]2(CCCC2)C)CS[C@@H]2[C@@H](C(N12)=O)NC(=O)/C(/C1N=C(N)SC=1)=N\OC)(=O)[O-]

Computed Properties

  • Exact Mass: 480.12500
  • Monoisotopic Mass: 480.12496023g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 10
  • Heavy Atom Count: 32
  • Rotatable Bond Count: 6
  • Complexity: 869
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 2
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 1
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: -0.1
  • Topological Polar Surface Area: 204
  • Surface Charge: 0
  • Tautomer Count: 14

Experimental Properties

  • Color/Form: Colorless powder,melting point150℃(decomposition).
  • Melting Point: 150 C
  • Boiling Point: No data available
  • Flash Point: No data available
  • PSA: 203.58000
  • LogP: -0.41110
  • Vapor Pressure: No data available

Cefepime Security Information

Cefepime Customs Data

  • HS CODE：32041300
  • Customs Data：

    China Customs Code:

    32041300

Cefepime Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.
C861441-50mg
Cefepime
 88040-23-7 ＞98%
50mg
 ￥128.00 2022-09-02
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.
C861441-200mg
Cefepime
 88040-23-7 ＞98%
200mg
 ￥376.00 2022-09-02
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.
C861441-1g
Cefepime
 88040-23-7 ＞98%
1g
 ￥1,350.00 2022-09-02
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.
C861441-5g
Cefepime
 88040-23-7 ＞98%
5g
 ￥4,280.00 2022-09-02
MedChemExpress
HY-B0692-50mg
Cefepime
 88040-23-7 99.18%
50mg
 ￥500 2025-04-15
MedChemExpress
HY-B0692-100mg
Cefepime
 88040-23-7 99.18%
100mg
 ￥800 2025-04-15
MedChemExpress
HY-B0692-500mg
Cefepime
 88040-23-7 99.18%
500mg
 ￥1450 2025-04-15
eNovation Chemicals LLC
Y0974271-1g
Cefepime
 88040-23-7 98%
1g
 $600 2024-08-03
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
C304822-200mg
Cefepime
 88040-23-7 98%
200mg
 ￥368.90 2023-09-03
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
C304822-1g
Cefepime
 88040-23-7 98%
1g
 ￥1323.90 2023-09-03

Cefepime Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Sodium bicarbonate Solvents: Dimethylformamide ,  Water
1.2 Reagents: Sulfuric acid
Reference
Synthesis and structure-activity relationships of a new series of cephalosporins, BMY-28142 and related compounds
Naito, Takayuki; et al, Journal of Antibiotics, 1986, 39(8), 1092-107

Production Method 2

Reaction Conditions
1.1 Reagents: Formic acid ,  Hydrochloric acid Solvents: Acetone
2.1 Reagents: Sodium bicarbonate Solvents: Dimethylformamide ,  Water
2.2 Reagents: Sulfuric acid
Reference
Synthesis and structure-activity relationships of a new series of cephalosporins, BMY-28142 and related compounds
Naito, Takayuki; et al, Journal of Antibiotics, 1986, 39(8), 1092-107

Production Method 3

Reaction Conditions
1.1 Solvents: Carbon tetrachloride
2.1 Reagents: Formic acid ,  Hydrochloric acid Solvents: Acetone
3.1 Reagents: Sodium bicarbonate Solvents: Dimethylformamide ,  Water
3.2 Reagents: Sulfuric acid
Reference
Synthesis and structure-activity relationships of a new series of cephalosporins, BMY-28142 and related compounds
Naito, Takayuki; et al, Journal of Antibiotics, 1986, 39(8), 1092-107

Production Method 4

Reaction Conditions
1.1 Reagents: Sodium iodide Solvents: Carbon tetrachloride ,  Acetone
2.1 Solvents: Carbon tetrachloride
3.1 Reagents: Formic acid ,  Hydrochloric acid Solvents: Acetone
4.1 Reagents: Sodium bicarbonate Solvents: Dimethylformamide ,  Water
4.2 Reagents: Sulfuric acid
Reference
Synthesis and structure-activity relationships of a new series of cephalosporins, BMY-28142 and related compounds
Naito, Takayuki; et al, Journal of Antibiotics, 1986, 39(8), 1092-107

Production Method 5

Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Ethyl acetate ,  Water
1.2 -
2.1 Reagents: Sodium iodide Solvents: Carbon tetrachloride ,  Acetone
3.1 Solvents: Carbon tetrachloride
4.1 Reagents: Formic acid ,  Hydrochloric acid Solvents: Acetone
5.1 Reagents: Sodium bicarbonate Solvents: Dimethylformamide ,  Water
5.2 Reagents: Sulfuric acid
Reference
Synthesis and structure-activity relationships of a new series of cephalosporins, BMY-28142 and related compounds
Naito, Takayuki; et al, Journal of Antibiotics, 1986, 39(8), 1092-107

Production Method 6

Reaction Conditions
1.1 Reagents: Trifluoroacetic acid Solvents: Trifluoroacetic acid
2.1 Reagents: Sodium 2-ethylhexanoate Solvents: Methanol ,  Ethyl acetate
Reference
Synthesis and structure-activity relationships of a new series of cephalosporins, BMY-28142 and related compounds
Naito, Takayuki; et al, Journal of Antibiotics, 1986, 39(8), 1092-107

Production Method 7

Reaction Conditions
1.1 Reagents: Triethylamine Solvents: Ethanol ,  Water ;  0 - 5 °C
1.2 2 h, 0 - 5 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1.5
Reference
A novel synthetic route of 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methylpyrrolidinium inner salt (cefepime)
Yu, Pei; et al, Zhongguo Kangshengsu Zazhi, 2007, 32(12), 751-753

Production Method 8

Reaction Conditions
1.1 Reagents: Pyridine ,  Phosphorus pentachloride Solvents: Dichloromethane ;  rt → 0 °C; 0 °C; 0 °C → -10 °C; -10 °C; 1 h, -10 °C
1.2 Solvents: Methanol ,  Phenol ;  -10 °C; 3 - 5 h, -10 °C
1.3 Reagents: Ammonium hydroxide Solvents: Water ;  pH 2 - 2.5
2.1 Reagents: Triethylamine Solvents: Ethanol ,  Water ;  0 - 5 °C
2.2 2 h, 0 - 5 °C
2.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1.5
Reference
A novel synthetic route of 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methylpyrrolidinium inner salt (cefepime)
Yu, Pei; et al, Zhongguo Kangshengsu Zazhi, 2007, 32(12), 751-753

Production Method 9

Reaction Conditions
1.1 Reagents: Potassium iodide Solvents: Acetone ;  3 h, rt
1.2 Solvents: Dichloromethane ;  -10 °C; 1 h, -10 °C
1.3 Reagents: Diisopropyl ether
2.1 Reagents: Pyridine ,  Phosphorus pentachloride Solvents: Dichloromethane ;  rt → 0 °C; 0 °C; 0 °C → -10 °C; -10 °C; 1 h, -10 °C
2.2 Solvents: Methanol ,  Phenol ;  -10 °C; 3 - 5 h, -10 °C
2.3 Reagents: Ammonium hydroxide Solvents: Water ;  pH 2 - 2.5
3.1 Reagents: Triethylamine Solvents: Ethanol ,  Water ;  0 - 5 °C
3.2 2 h, 0 - 5 °C
3.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1.5
Reference
A novel synthetic route of 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methylpyrrolidinium inner salt (cefepime)
Yu, Pei; et al, Zhongguo Kangshengsu Zazhi, 2007, 32(12), 751-753

Production Method 10

Reaction Conditions
1.1 Reagents: Cupric chloride Solvents: Methanol ,  Water ;  12 h, rt
Reference
Synthesis and antibacterial activity of copper(II) complexes with sulphathiazole and cephalosporin ligands
Anacona, Juan R.; et al, Transition Metal Chemistry (Dordrecht, 2008, 33(4), 517-521

Production Method 11

Reaction Conditions
1.1 Solvents: Methanol
1.2 Reagents: Sodium 2-ethylhexanoate Solvents: Ethyl acetate
Reference
Synthesis and structure-activity relationships of a new series of cephalosporins, BMY-28142 and related compounds
Naito, Takayuki; et al, Journal of Antibiotics, 1986, 39(8), 1092-107

Production Method 12

Reaction Conditions
1.1 Reagents: Sodium 2-ethylhexanoate Solvents: Methanol ,  Ethyl acetate
Reference
Synthesis and structure-activity relationships of a new series of cephalosporins, BMY-28142 and related compounds
Naito, Takayuki; et al, Journal of Antibiotics, 1986, 39(8), 1092-107

Production Method 13

Reaction Conditions
1.1 Reagents: Trifluoroacetic acid Solvents: Trifluoroacetic acid
2.1 Solvents: Methanol
2.2 Reagents: Sodium 2-ethylhexanoate Solvents: Ethyl acetate
Reference
Synthesis and structure-activity relationships of a new series of cephalosporins, BMY-28142 and related compounds
Naito, Takayuki; et al, Journal of Antibiotics, 1986, 39(8), 1092-107

Production Method 14

Reaction Conditions
1.1 Reagents: Acetyl chloride ,  Potassium iodide Solvents: Acetone
2.1 Reagents: Trifluoroacetic acid Solvents: Trifluoroacetic acid
3.1 Solvents: Methanol
3.2 Reagents: Sodium 2-ethylhexanoate Solvents: Ethyl acetate
Reference
Synthesis and structure-activity relationships of a new series of cephalosporins, BMY-28142 and related compounds
Naito, Takayuki; et al, Journal of Antibiotics, 1986, 39(8), 1092-107

Cefepime Raw materials

Cefepime Preparation Products

Cefepime Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:88040-23-7)無菌頭孢吡肟 （精氨酸）
Order Number:LE3296605;LE13214
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:42
Price ($):discuss personally

Cefepime Related Literature

Related Categories

88040-23-7 (Cefepime) Related Products

Recommended suppliers
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:88040-23-7)無菌頭孢吡肟 （精氨酸）
LE3296605;LE13214
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry
Email