Production Method 1

112258-91-0

88040-23-7

Reaction Conditions

1.1 Reagents: Acetyl chloride ,  Potassium iodide Solvents: Acetone
2.1 Reagents: Trifluoroacetic acid Solvents: Trifluoroacetic acid
3.1 Solvents: Methanol
3.2 Reagents: Sodium 2-ethylhexanoate Solvents: Ethyl acetate

Reference

Synthesis and structure-activity relationships of a new series of cephalosporins, BMY-28142 and related compounds

Naito, Takayuki; et al, Journal of Antibiotics, 1986, 39(8), 1092-107

Production Method 2

88376-58-3

14477-72-6

112258-91-0

88040-23-7

Reaction Conditions

1.1 Solvents: Methanol
1.2 Reagents: Sodium 2-ethylhexanoate Solvents: Ethyl acetate

Reference

Synthesis and structure-activity relationships of a new series of cephalosporins, BMY-28142 and related compounds

Naito, Takayuki; et al, Journal of Antibiotics, 1986, 39(8), 1092-107

Production Method 3

112258-91-0

88040-23-7

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid Solvents: Trifluoroacetic acid
2.1 Solvents: Methanol
2.2 Reagents: Sodium 2-ethylhexanoate Solvents: Ethyl acetate

Reference

Synthesis and structure-activity relationships of a new series of cephalosporins, BMY-28142 and related compounds

Naito, Takayuki; et al, Journal of Antibiotics, 1986, 39(8), 1092-107

Raw materials

• 7-[[2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• Acetic acid,2,2,2-trifluoro-, ion(1-)

Preparation Products

• (112258-91-0)
• Cefepime (88040-23-7)

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• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)