Production Method 1

16588-16-2

87815-77-8

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: N-Methyl-2-pyrrolidone ;  1.5 h, 90 °C
1.2 Reagents: Water

Reference

Development of safe one-pot synthesis of N-1- and C-2-substituted benzimidazole via reductive cyclization of o-nitroarylamine using Na2S2O4

Oda, Shinichi; et al, Organic Process Research & Development, 2012, 16(1), 96-101

Production Method 2

367-80-6

87815-77-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethyl sulfoxide ;  overnight, rt

Reference

Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: Identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole

Ishida, Tomio; et al, Bioorganic & Medicinal Chemistry Letters, 2006, 16(7), 1859-1863

Production Method 3

96-99-1

87815-77-8

Reaction Conditions

1.1 Catalysts: Sulfuric acid ;  8 h, 70 °C
2.1 Catalysts: Triethylamine Solvents: Tetrahydrofuran ;  30 min, rt; 24 h, rt

Reference

Synthesis and biological evaluation of some novel hydrazones carrying benzimidazole and pyrene/vanillin moiety

Gebretekle, Desta; et al, Journal of Applicable Chemistry (Lumami, 2021, 10(1), 12-21

Production Method 4

96-99-1

87815-77-8

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Ethanol ;  reflux
2.1 Reagents: Triethylamine Solvents: Tetrahydrofuran ;  24 h, rt
2.2 Reagents: Water ;  2 h, cooled

Reference

Design and synthesis of amino acid derivatives of substituted benzimidazoles and pyrazoles as selective Sirt1 inhibitors

Purushotham, Nikil; et al, ChemRxiv, 2020, 1, 1-59

Ethyl 4-(cyclohexylamino)-3-nitrobenzoate Raw materials

• Ethyl 4-fluoro-3-nitrobenzoate
• 4-Chloro-3-nitrobenzoic acid
• Ethyl 4-chloro-3-nitrobenzoate

Ethyl 4-(cyclohexylamino)-3-nitrobenzoate Preparation Products

• Ethyl 4-(cyclohexylamino)-3-nitrobenzoate (87815-77-8)

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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzoic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Nitrobenzoic acids and derivatives

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