Production Method 1

74-11-3

96-99-1

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Nitric acid ;  2.5 min, 25 °C

Reference

Process and device for selective nitration of p-chlorobenzoic acid

, China, , ,

Production Method 2

74-11-3

96-99-1

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Nitric acid Solvents: 1,2-Dichloroethane ,  Water ;  20 - 65 °C; 55 - 65 °C; 70 - 75 °C; rt → 25 °C

Reference

Synthesis of poly(2,5-benzimidazole)

, India, , ,

Production Method 3

74-11-3

96-99-1

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Nitric acid

Reference

Synthesis and application of alkali clearable disperse dyes derived from alkyl 4-amino-3-nitrobenzoates

Kang, Min Koo; Lee, Bum Hoon; Jaung, Jae Yun, Journal of the Korean Fiber Society, 2001, 38(8), 403-409

Production Method 4

74-11-3

96-99-1

Reaction Conditions

1.1 Reagents: Fuming nitric acid ;  1 h, heated

Reference

Synthesis of 1-heterocyclic aminomethyl-3-(4'-anilino-3'-nitrobenzoyl hydrazono)-2-indolinones as antifilarial and CNS active agents

Beg, M. S. J.; Gupta, S. P., Asian Journal of Chemistry, 2011, 23(4), 1569-1572

Production Method 5

74-11-3

96-99-1

Reaction Conditions

1.1 Reagents: Fuming nitric acid Solvents: Water ;  1 h, heated; cooled
1.2 Reagents: Water

Reference

Synthesis of 1-(N-substituted-carboxamido-2-aminophenyl)-4-methyl-piperazines: D.E.C. analogs and their antifilarial activity-II

Beg, M. S. J.; Singh, B. N.; Raj, Prem, Asian Journal of Chemistry, 2003, , 1343-1346

Production Method 6

16588-34-4

96-99-1

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Catalysts: Copper oxide (CuO) Solvents: Acetonitrile ,  Water ;  5 h, 1 atm, 60 °C

Reference

Bio-derived CuO nanocatalyst for oxidation of aldehyde: a greener approach

Tamuly, Chandan; Saikia, Indranirekha; Hazarika, Moushumi; Das, Manash R., RSC Advances, 2014, 4(40), 20636-20640

Production Method 7

74-11-3

96-99-1

Reaction Conditions

Reference

Synthesis of polynuclear heterocycles. Part 4. imidazo[4,5-g][3,1]benzoxazinones, imidazo[4,5-g]quinazolinones, imidazo[4,5-g]quinazolinediones, and imidazo[4,5-f]indazolinones

Alkhader, Mohamed A.; Perera, R. Clinton; Sinha, Rajeshwar P.; Smalley, Robert K., Journal of the Chemical Society, 1979, (1979), 1056-62

Production Method 8

74-11-3

96-99-1

Reaction Conditions

1.1 Reagents: Potassium nitrate

Reference

Nitration of some substituted aromatic compounds with potassium nitrate in polyphosphoric acid

Iqbal, Rashid; Rama, Nasim Hasan; Haq, Muhammad Zia Ul; Madhwa, Farag Ali, Journal of the Chemical Society of Pakistan, 1997, 19(2), 141-144

Production Method 9

22019-49-4

96-99-1

Reaction Conditions

1.1 Reagents: Poly(4-vinylpyridine) Solvents: Toluene ;  30 min, 125 °C
1.2 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  2 h, 115 °C
1.3 Reagents: Amberlyst 15 Solvents: Ethanol

Reference

Preparation of arene carboxylic acids via a polymer-supported Krohnke reaction

Brusotti, Gloria; Habermann, Joerg; Azzolina, Ornella; Collina, Simona, Letters in Organic Chemistry, 2006, 3(12), 943-947

Production Method 10

74-11-3

96-99-1

Reaction Conditions

1.1 Reagents: Nitric acid

Reference

Studies on new process of fast red KD base

Ma, Ying; Meng, Ming-yang; Tan, Li-zhe; Yang, Wen-dong, Jingxi Yu Zhuanyong Huaxuepin, 2003, 11(6), 18-19

Production Method 11

96-99-1

96-99-1

Reaction Conditions

1.1 Reagents: Cesium carbonate Solvents: Dimethylformamide ;  10 min, rt
1.2 10 min, rt; 24 h, 50 °C; 50 °C → rt

Reference

Bartoli Indole Synthesis on Solid Supports

Knepper, Kerstin; Brase, Stefan, Organic Letters, 2003, 5(16), 2829-2832

Production Method 12

74-11-3

96-99-1

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Nitric acid ;  30 °C; 6 h, 35 °C

Reference

Synthesis of 3-amino-4-hydroxyl benzoic acid phosphate

Quan, Baoxue; Jiang, Wenwei, Journal of the Chemical Society of Pakistan, 2015, 37(4), 755-759

Production Method 13

74-11-3

96-99-1

Reaction Conditions

1.1 Reagents: Sodium nitrate ,  Sulfuric acid ;  rt

Reference

Molecular design, synthesis and cell based HCV replicon assay of novel benzoxazole derivatives

Ismail, M. A. H.; Adel, M.; Ismail, N. S. M.; Abouzid, K. A. M., Drug Research (Stuttgart, 2013, 63(3), 109-120

Production Method 14

74-11-3

96-99-1

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water ;  0 °C; 0 °C → 20 °C
1.2 Reagents: Sulfuric acid ,  Nitric acid Solvents: Water ;  20 °C; 5 h, 60 °C

Reference

Synthesis of dabigatran etexilate

Xing, Songsong; Wang, Xiaolei; Zhou, Fugang; Su, Xinjie; Du, Yumin, Zhongguo Yiyao Gongye Zazhi, 2010, 41(5), 321-325

Production Method 15

74-11-3

96-99-1

Reaction Conditions

1.1 Reagents: Hydrochloric acid ,  Sulfuric acid ,  Nitric acid Solvents: Dichloromethane ;  0 °C; rt

Reference

Method for preparing dabigatran etexilate intermediate

, China, , ,

Production Method 16

74-11-3

96-99-1

Reaction Conditions

1.1 Reagents: Nitric acid

Reference

Synthesis of a novel dicarboxylic acid containing diazacycloheptatriene

Kamireddy, Audisesha Reddy; Mahalingam, Srinivasan, Chemistry & Industry (London, 1989, (1989), 228-9

Production Method 17

74-11-3

96-99-1

Reaction Conditions

1.1 Reagents: Sodium nitrate Solvents: Acetonitrile ;  > 1 min
1.2 Catalysts: [29H,31H-Phthalocyanine-C,C,C,C-tetrasulfonyl tetrachloridato(2-)-κN29,κN30,κN31… ;  2 - 3 h, 45 - 50 °C

Reference

Copper phthalocyanine tetrasulfonic acid (CuPcS) as an efficient recyclable catalyst for aromatic nitration using sodium nitrate

Patel, Siddharth S.; Patel, Dhaval B.; Poddar, Akhil K.; Patel, Jitesh B.; Rana, Dharmarajsinh N. ; et al, Journal of Molecular Structure, 2023, 1280,

Production Method 18

74-11-3

96-99-1

Reaction Conditions

1.1 Reagents: Fuming nitric acid ;  1 h, reflux
1.2 Reagents: Water ;  0 °C

Reference

Synthesis of methyl-4-anilino-3-amino/amino-acetyl benzoates as anti-filarial agents

Beg, M. S. J.; Singh, B. N.; Raj, Prem, Asian Journal of Chemistry, 2003, 15(1), 519-522

Production Method 19

74-11-3

96-99-1

Reaction Conditions

Reference

Synthesis of flubendazole

Wang, Baojun; Li, Ping, Yiyao Gongye, 1983, (11), 1-2

Production Method 20

96-99-1

Reaction Conditions

Reference

Optimization and anti-inflammatory evaluation of methyl gallate derivatives as a myeloid differentiation protein 2 inhibitor

Qiu, Yinda; Xiao, Zhongxiang; Wang, Yanyan; Zhang, Dingfang; Zhang, Wenxin; et al, Bioorganic & Medicinal Chemistry, 2019, 27(20),

4-Chloro-3-nitrobenzoic acid Raw materials

• 4-Chloro-3-nitrobenzaldehyde
• 4-Chlorobenzoic acid
• 4-Chloro-3-nitrobenzoic acid
• 2-Bromo-1-(4-chloro-3-nitro-phenyl)-ethanone

4-Chloro-3-nitrobenzoic acid Preparation Products

• 4-Chloro-3-nitrobenzoic acid (96-99-1)

• 1. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
• 2. An investigation into the origin of variations in photovoltaic performance using D–D–π–A and D–A–π–A triphenylimidazole dyes with a copper electrolyte?
  Govind Reddy Mol. Syst. Des. Eng., 2021,6, 779-789
• 3. An atomic scale study of defects in Co2FeAl
  Ravi Kumar Yadav,R. Govindaraj Phys. Chem. Chem. Phys., 2020,22, 26876-26886
• 4. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
• 5. An assay for the enzyme N-acetyl-β-d-glucosaminidase (NAGase) based on electrochemical detection using screen-printed carbon electrodes (SPCEs)
  R. M. Pemberton,J. P. Hart,T. T. Mottram Analyst, 2001,126, 1866-1871

• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 34662-36-7(3-Chloro-5-nitrobenzoic acid)
• 3970-35-2(2-Chloro-3-nitrobenzoic acid)
• 2552-45-6(Methyl 4-Chloro-3,5-dinitrobenzoate)
• 1143-31-3(Benzoic acid,2,6-dichloro-3,5-dinitro-)
• 14719-83-6(Methyl 4-chloro-3-nitrobenzoate)
• 39608-47-4(3-Chloro-4-nitrobenzoic acid)
• 2497-91-8(2-Chloro-3,5-dinitrobenzoic acid)
• 118-97-8(4-Chloro-3,5-dinitrobenzoic acid)
• 52729-03-0(2,4-Dichloro-3,5-dinitrobenzoic Acid)
• 55775-97-8(2,6-Dichloro-3-nitrobenzoic acid)