Cas no 874-24-8 (3-hydroxypyridine-2-carboxylic acid)

3-hydroxypyridine-2-carboxylic acid structure
874-24-8 structure
Product Name:3-hydroxypyridine-2-carboxylic acid
CAS No:874-24-8
MF:C6H5NO3
MW:139.108801603317
MDL:MFCD00006294
CID:40142
PubChem ID:87571150
Update Time:2024-10-26

3-hydroxypyridine-2-carboxylic acid Chemical and Physical Properties

Names and Identifiers

    • 3-Hydroxypicolinic acid
    • TIMTEC-BB SBB006727
    • RARECHEM AL BO 0972
    • 2-PYRIDINECARBOXYLIC ACID, 3-HYDROXY-
    • 3-HYDROXYPYRIDINE-2-CARBOXYLIC ACID
    • 3-HPA
    • 3-HYDROXYPICOLINIC ACID, MATRIX SUB-STAN CE FOR MALDI-MS
    • 3-Hydroxy-2-pyridinecarboxylic Acid
    • 2-Carboxy-3-hydroxypyridine
    • 3-Hydroxy-2-carboxypyridine
    • 3-Hydroxy-2-Pyridinecarboxylic
    • 3-hydroxy-picolinic acid
    • 3-hydroxy-pyridine-2-carboxylic acid
    • hydroxypicolinic acid
    • 3-Hydroxy-2-pyridinecarboxylic acid (ACI)
    • Picolinic acid, 3-hydroxy- (6CI, 7CI, 8CI)
    • 3-Hydroxy-2-pyridinecarboxylic acid #
    • H0787
    • NCIOpen2_001249
    • EN300-51029
    • 3-Hydroxypicolinic acid (3-Hydroxypyridine-2-carboxylic acid)
    • CHEBI:64342
    • 3-hydroxypyridine-2-carboxylate
    • PD069985
    • HY-Y0030
    • SY017848
    • DTXSID80236320
    • NS00014723
    • AKOS005170696
    • AM20070266
    • CS-D1114
    • CHEMBL1234326
    • HY-Y0030A
    • BDBM50122011
    • 3-hydroxy-2-pyridine carboxylic acid
    • 3-Hydroxypicolinate
    • PB46989
    • AC-907/25014108
    • W-104023
    • EINECS 212-859-0
    • PS-3718
    • 3-Hydroxypyridine-2-carboxylic acid, 98%
    • C18620
    • 3-Hydroxypicolinic acid, purum, >=96.0% (T)
    • MHW
    • 3-Hydroxypicolinic acid, matrix substance for MALDI-MS, >=99.0% (HPLC)
    • Pyridinecarboxylic acid, hydroxy-
    • 116357-04-1
    • 3-hydroxy picolinic acid
    • SCHEMBL78249
    • S6252
    • FT-0615860
    • 3-Hydroxypicolinicacid
    • Picolinic acid, 3-hydroxy- (6CI,7CI,8CI)
    • Q10859486
    • 874-24-8
    • 3-hydroxylpicolinic acid
    • CS-0899663
    • Z608353738
    • 3-Hydroxy-2-pyridinecarboxylate
    • UNII-XV7XP64JR5
    • 3-Hydroxypyridinium-2-carboxylate
    • XV7XP64JR5
    • AC-26465
    • BP-12461
    • 3-Hydroxypicolinic acid, matrix substance for MALDI-MS
    • MFCD00006294
    • STL227625
    • BBL100164
    • DB-016012
    • 3-hydroxypyridine-2-carboxylic acid
    • MDL： MFCD00006294
    • Inchi： 1S/C6H5NO3/c8-4-2-1-3-7-5(4)6(9)10/h1-3,8H,(H,9,10)
    • InChI Key： BRARRAHGNDUELT-UHFFFAOYSA-N
    • SMILES： O=C(C1C(O)=CC=CN=1)O
    • BRN： 118954

Computed Properties

  • Exact Mass: 139.02700
  • Monoisotopic Mass: 139.026943
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 1
  • Complexity: 137
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 4
  • XLogP3: nothing
  • Topological Polar Surface Area: 70.4

Experimental Properties

  • Color/Form: Light brown to tan crystalline powder
  • Density: 1.4429 (rough estimate)
  • Melting Point: 213-218?°C (lit.)
  • Boiling Point: 255.04°C (rough estimate)
  • Flash Point: 226.6℃
  • Refractive Index: 1.5423 (estimate)
  • Water Partition Coefficient: Soluble in water (0.25g in 10ml).
  • PSA: 70.42000
  • LogP: 0.48540
  • Solubility: Not determined

3-hydroxypyridine-2-carboxylic acid Security Information

  • Symbol: GHS07
  • Prompt：warning
  • Signal Word：Warning
  • Hazard Statement： H315-H319-H335
  • Warning Statement： P261-P305+P351+P338
  • Hazardous Material transportation number：NONH for all modes of transport
  • WGK Germany：3
  • Hazard Category Code： 36/37/38
  • Safety Instruction： S26-S28-S36/37/39
  • FLUKA BRAND F CODES：10
  • Hazardous Material Identification： Xn
  • HazardClass：IRRITANT
  • Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
  • Packing Group：II
  • Risk Phrases：R20/22; R36/37/38

3-hydroxypyridine-2-carboxylic acid Customs Data

  • HS CODE：2933399090
  • Customs Data：

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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3-hydroxypyridine-2-carboxylic acid Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Sulfuric acid ,  Chromic acid (H2Cr2O7), compd. with quinoline (1:2) Solvents: Water ;  rt; rt → 50 °C
1.2 Solvents: Acetic acid ,  Water ;  24 h, 50 °C
Reference
Quinolinium dichromate oxidation of heterocyclic carboxylic acids
Suante, Hauzachin; et al, Heterocyclic Communications, 2003, 9(5), 489-492

Production Method 2

Reaction Conditions
1.1 Reagents: Hydrochloric acid
Reference
Grividomycins I, II and III, new antibiotics of the streptogramin class from Streptomyces sp. HIL Y-8240155
Mukhopadhyay, Triptikumar; et al, Tetrahedron, 1998, 54(26), 7625-7632

Production Method 3

Reaction Conditions
Reference
Biosynthesis of antibiotics of the virginiamycin family, 6. Biosynthesis of virginiamycin S1
Molinero, Anthony A.; et al, Journal of Natural Products, 1989, 52(1), 99-108

Production Method 4

Reaction Conditions
1.1 Reagents: Sodium molybdate (Na2MoO4) ,  Europium nitrate Solvents: Water ;  rt; rt → 140 °C; 3 d, 140 °C; 140 °C → rt
Reference
Polynuclear molybdenum and tungsten complexes containing 3-hydroxypicolinic acid and europium(III)
Rodrigues, Manuela J. E.; et al, Materials Science Forum, 2006, 514, 514-516

Production Method 5

Reaction Conditions
1.1 Reagents: Potassium hydroxide ,  Europium trichloride hexahydrate ,  Terbium trichloride hexahydrate Solvents: Water ;  90 min, rt
1.2 1 h, rt; 30 min, 80 °C; 8 h, 80 °C
Reference
Nanoencapsulation of Luminescent 3-Hydroxypicolinate Lanthanide Complexes
Iwu, Kingsley O.; et al, Journal of Physical Chemistry C, 2009, 113(18), 7567-7573

Production Method 6

Reaction Conditions
1.1 Reagents: Sulfuric acid ,  Chromic acid (H2Cr2O7), compd. with quinoline (1:2) Solvents: Acetic acid ,  Water ;  cooled; rt; rt → 323 K; 48 h, 323 K
2.1 Reagents: Sulfuric acid ,  Chromic acid (H2Cr2O7), compd. with quinoline (1:2) Solvents: Acetic acid ,  Water ;  cooled; rt; rt → 323 K; 48 h, 323 K
Reference
Kinetics of oxidation of heterocyclic compounds by quinolinium dichromate
Saunte, Hauzachin; et al, Croatica Chemica Acta, 2010, 83(3), 291-298

Production Method 7

Reaction Conditions
Reference
Biosynthesis of antibiotics of the virginiamycin family. 7. Stereo- and regiochemical studies on the formation of the 3-hydroxypicolinic acid and pipecolic acid units
Reed, Josephine W.; et al, Journal of Organic Chemistry, 1989, 54(5), 1161-5

Production Method 8

Reaction Conditions
1.1 Reagents: Sodium nitrite ,  Hydrochloric acid Solvents: Water ;  rt; rt → 5 °C; 5 °C; 0.5 h, 5 °C
Reference
3-Hydroxy-4-oxo-3,4-dihydro-5-azabenzo-1,2,3-triazene
Carpino, Louis A.; et al, Journal of Organic Chemistry, 2004, 69(1), 54-61

Production Method 9

Reaction Conditions
1.1 Reagents: Sulfuric acid ,  Chromic acid (H2Cr2O7), compd. with quinoline (1:2) Solvents: Acetic acid ,  Water ;  cooled; rt; rt → 323 K; 48 h, 323 K
Reference
Kinetics of oxidation of heterocyclic compounds by quinolinium dichromate
Saunte, Hauzachin; et al, Croatica Chemica Acta, 2010, 83(3), 291-298

Production Method 10

Reaction Conditions
1.1 Reagents: Sulfuric acid ,  Chromic acid (H2Cr2O7), compd. with quinoline (1:2) Solvents: Acetic acid ,  Water ;  cooled; rt; rt → 323 K; 48 h, 323 K
Reference
Kinetics of oxidation of heterocyclic compounds by quinolinium dichromate
Suante, H.; et al, Oxidation Communications, 2008, 31(4), 841-852

Production Method 11

Reaction Conditions
Reference
Biosynthesis of antibiotics of the virginiamycin family. 7. Stereo- and regiochemical studies on the formation of the 3-hydroxypicolinic acid and pipecolic acid units
Reed, Josephine W.; et al, Journal of Organic Chemistry, 1989, 54(5), 1161-5

Production Method 12

Reaction Conditions
1.1 Reagents: Sodium acetate ,  Erbium chloride ,  Potassium phosphotungstate (K10P2W17O61) Solvents: Water ;  pH 5.5, 70 °C
1.2 Reagents: Potassium chloride Solvents: Water ;  30 min, 70 °C
Reference
Lanthanopolyoxometalates as Building Blocks for Multiwavelength Photoluminescent Organic-Inorganic Hybrid Materials
Granadeiro, Carlos M.; et al, European Journal of Inorganic Chemistry, 2009, (34), 5088-5095

Production Method 13

Reaction Conditions
1.1 Reagents: Sulfuric acid ,  Chromic acid (H2Cr2O7), compd. with quinoline (1:2) Solvents: Acetic acid ,  Water ;  cooled; rt; rt → 323 K; 48 h, 323 K
2.1 Reagents: Sulfuric acid ,  Chromic acid (H2Cr2O7), compd. with quinoline (1:2) Solvents: Acetic acid ,  Water ;  cooled; rt; rt → 323 K; 48 h, 323 K
Reference
Kinetics of oxidation of heterocyclic compounds by quinolinium dichromate
Suante, H.; et al, Oxidation Communications, 2008, 31(4), 841-852

Production Method 14

Reaction Conditions
Reference
Biosynthesis of antibiotics of the virginiamycin family. 7. Stereo- and regiochemical studies on the formation of the 3-hydroxypicolinic acid and pipecolic acid units
Reed, Josephine W.; et al, Journal of Organic Chemistry, 1989, 54(5), 1161-5

Production Method 15

Reaction Conditions
1.1 Solvents: Benzene
Reference
Diorganotin(IV) dipicolinates and bis(2-hydroxypicolinates): synthesis, characterization and in vitro antitumor activity
Gielen, Marcel; et al, Main Group Metal Chemistry, 1991, 14(5), 271-81

3-hydroxypyridine-2-carboxylic acid Raw materials

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3-hydroxypyridine-2-carboxylic acid Suppliers

Amadis Chemical Company Limited
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(CAS:874-24-8)3-Hydroxypicolinic acid
Order Number:A10403
Stock Status:in Stock
Quantity:100g/500g
Purity:99%
Pricing Information Last Updated:Thursday, 29 August 2024 17:08
Price ($):205.0/1025.0

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Amadis Chemical Company Limited
(CAS:874-24-8)3-Hydroxypicolinic acid
A10403
Purity:99%/99%
Quantity:100g/500g
Price ($):205.0/1025.0
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