Production Method 1

872-55-9

Reaction Conditions

1.1 Reagents: Triethylene glycol ,  Potassium hydroxide ;  rt → 100 °C
1.2 4 h, 140 °C

Reference

Methyl Hydrazinocarboxylate as a Practical Alternative to Hydrazine in the Wolff-Kishner Reaction

Cranwell, Philippa B.; et al, Synlett, 2016, 27(1), 131-135

Production Method 2

872-55-9

Reaction Conditions

1.1 Catalysts: Alumina

Reference

The preparation of thiophenes. II. From C5-C7-molecules and carbon disulfide

Azizian, Farid; et al, Journal of Chemical Technology and Biotechnology (1979-1982), 1980, 30(11), 648-53

Production Method 3

88-15-3

872-55-9

Reaction Conditions

1.1 Reagents: Carbon monoxide ,  1,8-Diazabicyclo[5.4.0]undec-7-ene ,  Water ,  Selenium Solvents: Tetrahydrofuran

Reference

Carbonyl-to-methylene conversion: selenium-assisted reduction of aromatic ketones with carbon monoxide and water

Nishiyama, Yutaka; et al, Journal of Organic Chemistry, 1988, 53(6), 1326-9

Production Method 4

37054-20-9

872-55-9

Reaction Conditions

1.1 Solvents: Hexamethylphosphoramide

Reference

Formation of 2H-thiopyrans and thiophenes by thermal rearrangement of propargyl vinyl sulfide or its homologs and 2-alkynyl thienyl sulfides

Schuijl-Laros, D.; et al, Recueil des Travaux Chimiques des Pays-Bas, 1972, 91(6), 785-98

Production Method 5

872-55-9

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ;  -78 °C; -78 °C → -25 °C; -25 °C → -78 °C
1.2 -78 °C; -78 °C → rt; 12 h, rt

Reference

Oligothiophenes substituted with the thionitrile group: synthesis, characterization, and thin-film formation on gold substrates

Morgan, Ian S.; et al, Journal of Materials Chemistry, 2009, 19(43), 8162-8168

Production Method 6

872-55-9

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether

Reference

Heteroatom-facilitated lithiations

Gschwend, Heinz W.; et al, Organic Reactions (Hoboken, 1979, 26,

Production Method 7

111-27-3

872-55-9

Reaction Conditions

1.1 Catalysts: Alumina

Reference

The preparation of thiophenes. II. From C5-C7-molecules and carbon disulfide

Azizian, Farid; et al, Journal of Chemical Technology and Biotechnology (1979-1982), 1980, 30(11), 648-53

Production Method 8

17249-86-4

872-55-9

Reaction Conditions

1.1 Reagents: Hydrogen sulfide

Reference

High-temperature organic synthesis. VII. Effect of the nature of substituents on the course of the reaction of hydrogen sulfide with chloro derivatives of aromatic and thiophene series

Shagun, L. G.; et al, Zhurnal Organicheskoi Khimii, 1978, 14(1), 187-92

Production Method 9

33922-80-4

96-43-5

872-55-9

Reaction Conditions

Reference

High-temperature organic synthesis. XXXV. Thermal reactions of di-1-propenyl sulfide

Ostroukhova, L. A.; et al, Zhurnal Organicheskoi Khimii, 1991, 27(2), 354-9

Production Method 10

33922-80-4

1003-09-4

872-55-9

Reaction Conditions

Reference

High-temperature organic synthesis. XXXV. Thermal reactions of di-1-propenyl sulfide

Ostroukhova, L. A.; et al, Zhurnal Organicheskoi Khimii, 1991, 27(2), 354-9

Production Method 11

872-55-9

Reaction Conditions

1.1 Catalysts: Ruthenium, (acetonitrile)carbonyl[hydrotris(1H-pyrazolato-κN1)borato(1-)-κN2,κN2… Solvents: Thiophene ;  40 psi, 90 °C

Reference

Reactions of TpRu(CO)(NCMe)(Me) (Tp = Hydridotris(pyrazolyl)borate) with Heteroaromatic Substrates: Stoichiometric and Catalytic C-H Activation

Pittard, Karl A.; et al, Organometallics, 2004, 23(23), 5514-5523

Production Method 12

2786-07-4

872-55-9

Reaction Conditions

Reference

Product class 10: thiophenes, thiophene 1,1-dioxides, and thiophene 1-oxides

Schatz, J., Science of Synthesis, 2002, 9, 287-422

Production Method 13

765-50-4

872-55-9

Reaction Conditions

1.1 Reagents: Naphthalene, radical ion(1-), lithium (1:1) Solvents: Tetrahydrofuran ;  20 °C; 18 min, 160 °C; 10 min, 250 °C

Reference

Benzyllithiums bearing aldehyde carbonyl groups. A flash chemistry approach

Nagaki, Aiichiro; et al, Organic & Biomolecular Chemistry, 2015, 13(26), 7140-7145

Production Method 14

88-15-3

872-55-9

Reaction Conditions

1.1 Reagents: Hydrogen Solvents: Acetic acid

Reference

Catalytic reduction of 2-acylthiophenes

Campaigne, E. E.; et al, Journal of the American Chemical Society, 1951, 73, 5240-3

Production Method 15

1918-82-7

872-55-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Platinum Solvents: Ethanol ,  Tetrahydrofuran ;  11 s, 14.7 atm, 70 °C

Reference

Continuous-flow hydrogenation of olefins and nitrobenzenes catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

Osako, Takao; et al, RSC Advances, 2015, 5(57), 45760-45766

Production Method 16

872-55-9

Reaction Conditions

1.1 Solvents: Dimethylformamide ;  rt → 0 °C
1.2 Reagents: Phosphorus sulfide (P2S5) ;  0 °C → 90 °C
1.3 5 h, 90 °C; 90 °C → rt
1.4 Solvents: Diethyl ether ;  rt
1.5 Reagents: Hydrochloric acid Solvents: Water ;  rt

Reference

Synthesis and properties of 2-substituted thiophenes

Ibrahimov, V. H.; et al, Kimya Problemlari, 2007, (3), 525-528

Production Method 17

872-55-9

Reaction Conditions

1.1 Catalysts: Aluminum chloride ,  1-Butyl-3-methylimidazolium hexafluorophosphate Solvents: tert-Butanol ;  2 h, reflux

Reference

Activity Investigation of Imidazolium-Based Ionic Liquid as Catalyst for Friedel-Crafts Alkylation of Aromatic Compounds

Cai, Mingjian; et al, Asian Journal of Chemistry, 2015, 27(2), 649-653

Production Method 18

505-57-7

872-55-9

Reaction Conditions

1.1 Reagents: Alumina ,  Hydrogen sulfide ,  Potassium oxide

Reference

A new catalytic synthesis of thiophenes

Barrault, Joel; et al, Journal of Chemical Research, 1978, (6),

Production Method 19

638-02-8

872-55-9

Reaction Conditions

1.1 Reagents: Phosphoric acid

Reference

Aqueous high-temperature chemistry of carbo- and heterocycles. 17. Thiophene, tetrahydrothiophene, 2-methylthiophene, 2,5-dimethylthiophene, benzo[b]thiophene, and dibenzothiophene

Katritzky, Alan R.; et al, Energy & Fuels, 1992, 6(4), 431-8

Production Method 20

33922-80-4

872-55-9

Reaction Conditions

Reference

High-temperature organic synthesis. XXXV. Thermal reactions of di-1-propenyl sulfide

Ostroukhova, L. A.; et al, Zhurnal Organicheskoi Khimii, 1991, 27(2), 354-9

Production Method 21

872-55-9

Reaction Conditions

Reference

Electrochemical deposition of highly-conducting metal dithiolene films

Allwright, Emily; et al, Dalton Transactions, 2016, 45(22), 9363-9368

Production Method 22

872-55-9

Reaction Conditions

Reference

Product class 10: thiophenes, thiophene 1,1-dioxides, and thiophene 1-oxides

Schatz, J., Science of Synthesis, 2002, 9, 287-422

Production Method 23

4298-52-6

872-55-9

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: Cobalt nickel alloy Solvents: Ethanol ;  8 h, 80 °C

Reference

Bimetallic CoNi Nanoflowers for Catalytic Transfer Hydrogenation of Terminal Alkynes

Choudhary, Neha; et al, ChemistrySelect, 2022, 7(37),

Production Method 24

95-15-8

872-55-9

Reaction Conditions

1.1 Reagents: Phosphoric acid

Reference

Aqueous high-temperature chemistry of carbo- and heterocycles. 17. Thiophene, tetrahydrothiophene, 2-methylthiophene, 2,5-dimethylthiophene, benzo[b]thiophene, and dibenzothiophene

Katritzky, Alan R.; et al, Energy & Fuels, 1992, 6(4), 431-8

2-Ethylthiophene Raw materials

• 2-(Chloromethyl)thiophene
• 2-Ethynylthiophene
• 1-Propene, 1,1'-thiobis-, (1E,1'E)-
• 2-Acetylthiophene
• 2-Bromothiophene
• Thianaftene
• 2-Chlorothiophene
• 2-Vinylthiophene
• 3-(Ethenylthio)-1-butyne
• 2-chloro-5-ethylthiophene
• 2,5-Dimethylthiophene
• 1-Hexanol
• 2-Thienyl-lithium
• hex-2-enal

2-Ethylthiophene Preparation Products

• 2-Ethylthiophene (872-55-9)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Heteroaromatic compounds Heteroaromatic compounds
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Heteroaromatic compounds

• 4341-34-8(Di(thiophen-2-yl)methane)
• 4218-22-8(2,2'-methylenebis[5-methylthiophene])
• 147871-77-0(Thiophene,2-ethyl-5-(1-methylethyl)-)
• 69280-76-8(Thiophene, propyl-)
• 73650-69-8(13,14-Dithiatricyclo[8.2.1.14,7]tetradeca-4,6,10,12-tetraene,stereoisomer)
• 33933-73-2(2-methyl-5-propylthiophene)
• 83773-63-1(N/A)
• 5069-23-8(2,5-diethylthiophene)
• 40323-88-4(2-Ethyl-5-methylthiophene)
• 1551-27-5(2-Propylthiophene)