Production Method 1

96-43-5

Reaction Conditions

1.1 Reagents: Triethylamine ,  Hydrochloric acid Solvents: Water ;  rt → 0 °C
1.2 Reagents: Hydrogen peroxide Solvents: Water ;  8 - 10 h, -10 - 0 °C; 10 h, -10 - 0 °C

Reference

Synthesis method of 2-chlorothiophene

, China, , ,

Production Method 2

96-43-5

Reaction Conditions

1.1 Reagents: Chlorine Solvents: 1,2-Dichloroethane ;  4 h, 35 - 40 °C; 40 °C → 55 °C; 2 h, 50 - 55 °C

Reference

Method for preparing 2-chloro-5-thiophenecarboxylic acid

, China, , ,

Production Method 3

96-43-5

Reaction Conditions

1.1 Reagents: Chlorosuccinimide Catalysts: Perchloric acid Solvents: Carbon tetrachloride

Reference

Biphasic electrophilic halogenation of activated aromatics and heteroaromatics with N-halosuccinimides catalyzed by perchloric acid

Goldberg, Yuri; Alper, Howard, Journal of Organic Chemistry, 1993, 58(11), 3072-5

Production Method 4

2309-47-9

96-43-5

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Cupric chloride ,  Oxygen ,  Silver oxide (Ag2O) Catalysts: 1,10-Phenanthroline Solvents: Dimethyl sulfoxide ;  18 - 36 h, 0.5 MPa, 140 °C

Reference

Dehydroxyalkylative halogenation of C(aryl)-C bonds of aryl alcohols

Liu, Mingyang; Zhang, Zhanrong; Liu, Huizhen; Wu, Tianbin; Han, Buxing, Chemical Communications (Cambridge, 2020, 56(52), 7120-7123

Production Method 5

96-43-5

Reaction Conditions

1.1 Reagents: Sulfuryl chloride

Reference

Synthesis of New Thieno[2,3-d]imidazoles

Kollmann, Hermann, 1981, , ,

Production Method 6

96-43-5

Reaction Conditions

1.1 Reagents: Sulfuryl chloride Solvents: Dichloromethane ;  0 °C; 2 h, 25 °C

Reference

Preparation of 5-chlorothiophene-2-carboxylic acid as rivaroxaban intermediate

, China, , ,

Production Method 7

96-43-5

Reaction Conditions

1.1 Reagents: Sulfuryl chloride

Reference

Substituted Thieno[3,2-b]pyrrolones

Loesel, Rainer, 1992, , ,

Production Method 8

3172-52-9

96-43-5

Reaction Conditions

Reference

Catalytic reductive dehalogenation of thiophene derivatives

Sharf, V. Z.; Taits, S. Z.; Gurovets, A. S.; Vol'kenshtein, Yu. B.; Fabrichnyi, B. P.; et al, Khimiya Geterotsiklicheskikh Soedinenii, 1982, (2), 171-5

Production Method 9

96-43-5

Reaction Conditions

1.1 Reagents: N-Chloro-N-(phenylsulfonyl)benzenesulfonamide Solvents: Acetonitrile ;  40 min, 20 - 25 °C
1.2 Reagents: Water Solvents: Dichloromethane ;  10 - 15 min, 20 - 25 °C

Reference

Activator free, expeditious and eco-friendly chlorination of activated arenes by N-chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI)

Misal, Balu; Palav, Amey; Ganwir, Prerna; Chaturbhuj, Ganesh, Tetrahedron Letters, 2021, 63,

Production Method 10

1003-09-4

96-43-5

Reaction Conditions

Reference

Preparation of chlorothiophenes from bromothiophenes

Conde, S.; Corral, C.; Madronero, R.; Sanchez Alvarez-Insua, A., Synthesis, 1976, 6, 412-13

Production Method 11

96-43-5

Reaction Conditions

1.1 Reagents: Triethylamine, hydrochloride ,  Bis[(3-nitrophenyl)sulfonyl] peroxide Solvents: Acetonitrile

Reference

Halogenations of aromatic compounds with halide anions in the presence of nitrobenzenesulfonyl peroxides. A novel method for the formation of positive halogens

Yoshida, Masato; Mochizuki, Hideki; Kamigata, Nobumasa, Chemistry Letters, 1988, (12), 2017-20

Production Method 12

96-43-5

Reaction Conditions

1.1 Reagents: Thionyl chloride

Reference

Synthesis of 2-Alkoxythiophenes

Pusterer, Friederich, 1982, , ,

Production Method 13

96-43-5

Reaction Conditions

1.1 Reagents: Sulfuryl chloride

Reference

Ring Closures with Hydroxythiophenes

Holzer, Wolfgang, 1982, , ,

Production Method 14

96-43-5

Reaction Conditions

Reference

Formation of 2- and 3-chlorothiophene in the pyrolysis of bis (β-chlorovinyl) sulfide

Perevalova, V. I.; Bannikova, O. B.; Keiko, V. V.; Deryagina, V. V.; Deryagina, E. N.; et al, Khimiya Geterotsiklicheskikh Soedinenii, 1979, (2),

Production Method 15

3172-52-9

96-43-5

Reaction Conditions

1.1 Reagents: Hydrogen sulfide

Reference

High-temperature organic synthesis. VII. Effect of the nature of substituents on the course of the reaction of hydrogen sulfide with chloro derivatives of aromatic and thiophene series

Shagun, L. G.; Deriglazova, E. S.; Kashik, T. V.; Deryagina, E. N.; Voronkov, M. G., Zhurnal Organicheskoi Khimii, 1978, 14(1), 187-92

Production Method 16

40032-73-3

2873-18-9

96-43-5

Reaction Conditions

1.1 Reagents: Tetramethylammonium perchlorate Solvents: Dimethylformamide

Reference

Electrochemical reduction of dihalothiophenes at silver cathodes in dimethylformamide: Evidence for a halogen dance

Walker, Brett A.; Martin, Erin T.; Mubarak, Mohammad S.; Peters, Dennis G., Journal of Electroanalytical Chemistry, 2018, 808, 335-339

Production Method 17

96-43-5

Reaction Conditions

1.1 Reagents: tert-Butyl hypochlorite Solvents: Carbon tetrachloride ;  2 h, -10 °C; 30 min, -10 °C

Reference

Synthetic method of 2-(thiophen-2-yl)acetic acid

, China, , ,

Production Method 18

1003-09-4

96-43-5

Reaction Conditions

1.1 Reagents: Sodium chloride Catalysts: Iron chloride (FeCl3) Solvents: Acetonitrile ;  4 h, rt

Reference

Iron(III)-mediated photocatalytic selective substitution of aryl bromine by chlorine with high chloride utilization efficiency

Wang, Ying; Li, Lina; Ji, Hongwei; Ma, Wanhong; Chen, Chuncheng; et al, Chemical Communications (Cambridge, 2014, 50(18), 2344-2346

Production Method 19

96-43-5

Reaction Conditions

1.1 Reagents: Mercuric chloride Catalysts: Thiothionyl chloride

Reference

Preparation of 2-chlorofuran and 2-chlorothiophene from the respective furan and thiophene mercurials and disulfur dichloride

Khodeir, Mohammed N. M.; Skulski, Lech; Wroczynski, Piotr, Bulletin of the Polish Academy of Sciences, 1987, 34(11-12), 443-8

Production Method 20

18243-72-6

96-43-5

Reaction Conditions

1.1 Reagents: Sulfuryl chloride

Reference

Characteristics of the chlorination of thienyl- and methylthienylchlorosilanes

Motsarev, G. V.; Savushkina, V. I.; Inshakova, V. T.; Tabenko, B. M.; Chernyshev, E. A., Zhurnal Obshchei Khimii, 1982, 52(12), 2767-72

2-Chlorothiophene Raw materials

• 2,5-Dichlorothiophene
• silane, (dichloromethyl)-2-thienyl-
• 2-Bromothiophene
• 3-Bromo-2-chlorothiophene
• 2-Bromo-5-chlorothiophene
• 1-(thiophen-2-yl)ethan-1-ol

2-Chlorothiophene Preparation Products

• 2-Chlorothiophene (96-43-5)

• 1. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 2. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 3. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 4. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 5. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119

• Solvents and Organic Chemicals Organic Compounds Organohalogen compounds Aryl halides Aryl chlorides

• 3172-52-9(2,5-Dichlorothiophene)
• 312624-22-9(Zinc,bromo(5-chloro-2-thienyl)-)
• 6688-55-7(bromozinc(1+) 5-chlorothiophen-2-ide)
• 57155-55-2(Thiophene, chloro-)
• 111762-30-2(Magnesium,bromo(5-chloro-2-thienyl)-)
• 60729-36-4(Lithium 2-chlorothiophen-3-ide)
• 143034-26-8(Lithium, (2,5-dichloro-3-thienyl)-)
• 173777-89-4(2,5-DICHLOROTHIOPHENE)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)