Cas no 871519-25-4 (1-(4-((Trifluoromethyl)thio)phenyl)ethanamine)

1-(4-((Trifluoromethyl)thio)phenyl)ethanamine is a fluorinated aromatic amine featuring a trifluoromethylthio (–SCF?) substituent, which enhances its electron-withdrawing properties and metabolic stability. This compound is valuable in pharmaceutical and agrochemical research due to its potential as a versatile intermediate in the synthesis of bioactive molecules. The trifluoromethylthio group contributes to increased lipophilicity, improving membrane permeability and binding affinity in target interactions. Its structural motif is particularly useful in developing enzyme inhibitors and receptor modulators. The compound's stability under various reaction conditions makes it suitable for further functionalization, enabling diverse derivatization pathways for drug discovery and material science applications.
1-(4-((Trifluoromethyl)thio)phenyl)ethanamine structure
871519-25-4 structure
Product Name:1-(4-((Trifluoromethyl)thio)phenyl)ethanamine
CAS No:871519-25-4
MF:C9H10F3NS
MW:221.242611408234
MDL:MFCD18703057
CID:5039724
PubChem ID:68728568
Update Time:2026-02-28

1-(4-((Trifluoromethyl)thio)phenyl)ethanamine Chemical and Physical Properties

Names and Identifiers

    • 1-(4-[(Trifluoromethyl)sulfanyl]phenyl)ethan-1-amine
    • 1-(4-((Trifluoromethyl)thio)phenyl)ethanamine
    • 1-[4-(trifluoromethylsulfanyl)phenyl]ethanamine
    • Benzenemethanamine, alpha-methyl-4-[(trifluoromethyl)thio]-
    • α-Methyl-4-[(trifluoromethyl)thio]benzenemethanamine (ACI)
    • 1-[4-(Trifluoromethylthio)phenyl]ethanamine
    • 1-[4-[(Trifluoromethyl)sulfanyl]phenyl]ethan-1-amine
    • N11375
    • MFCD18703057
    • CS-0161929
    • 871519-25-4
    • A1-28292
    • SB80299
    • 1-{4-[(TRIFLUOROMETHYL)SULFANYL]PHENYL}ETHANAMINE
    • BS-51496
    • EN300-1933285
    • LNAPOOBGPIVJHX-UHFFFAOYSA-N
    • 1-{4-[(trifluoromethyl)sulfanyl]phenyl}ethan-1-amine
    • benzenemethanamine, a-methyl-4-[(trifluoromethyl)thio]-
    • SCHEMBL3649499
    • MDL： MFCD18703057
    • Inchi： 1S/C9H10F3NS/c1-6(13)7-2-4-8(5-3-7)14-9(10,11)12/h2-6H,13H2,1H3
    • InChI Key： LNAPOOBGPIVJHX-UHFFFAOYSA-N
    • SMILES： S(C(F)(F)F)C1C=CC(=CC=1)C(C)N

Computed Properties

  • Exact Mass: 221.04860498g/mol
  • Monoisotopic Mass: 221.04860498g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 2
  • Complexity: 175
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.9
  • Topological Polar Surface Area: 51.3

1-(4-((Trifluoromethyl)thio)phenyl)ethanamine Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
abcr
AB464845-250 mg
1-(4-[(Trifluoromethyl)sulfanyl]phenyl)ethan-1-amine; .
 871519-25-4
250mg
 €385.80 2023-04-21
SHANG HAI XIAN DING Biotechnology Co., Ltd.
B-VP334-50mg
1-(4-((Trifluoromethyl)thio)phenyl)ethanamine
 871519-25-4 97%
50mg
 594.0CNY 2021-07-14
SHANG HAI XIAN DING Biotechnology Co., Ltd.
B-VP334-200mg
1-(4-((Trifluoromethyl)thio)phenyl)ethanamine
 871519-25-4 97%
200mg
 1470.0CNY 2021-07-14
SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.
X29625-100mg
1-(4-((Trifluoromethyl)thio)phenyl)ethanamine
 871519-25-4 97%
100mg
 ￥185.0 2024-07-18
SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.
X29625-1g
1-(4-((Trifluoromethyl)thio)phenyl)ethanamine
 871519-25-4 97%
1g
 ￥1603.0 2024-07-18
SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.
X29625-250mg
1-(4-((Trifluoromethyl)thio)phenyl)ethanamine
 871519-25-4 97%
250mg
 ￥403.0 2024-07-18
TRC
T197590-125mg
1-(4-((Trifluoromethyl)thio)phenyl)ethanamine
 871519-25-4
125mg
 $ 565.00 2022-06-03
TRC
T197590-250mg
1-(4-((Trifluoromethyl)thio)phenyl)ethanamine
 871519-25-4
250mg
 $ 940.00 2022-06-03
eNovation Chemicals LLC
Y1223790-1g
1-(4-((Trifluoromethyl)thio)phenyl)ethanamine
 871519-25-4 95%
1g
 $700 2024-06-03
abcr
AB464845-250mg
1-(4-[(Trifluoromethyl)sulfanyl]phenyl)ethan-1-amine; .
 871519-25-4
250mg
 €132.50 2025-02-17

1-(4-((Trifluoromethyl)thio)phenyl)ethanamine Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Hydrogen ,  Ammonia Catalysts: Cobalt Solvents: Tetrahydrofuran ;  5 - 7 bar; 20 h, 40 bar, 120 °C
Reference
MOF-derived cobalt nanoparticles catalyze a general synthesis of amines
Jagadeesh, Rajenahally V. ; et al, Science (Washington, 2017, 358(6361), 326-332

1-(4-((Trifluoromethyl)thio)phenyl)ethanamine Raw materials

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1-(4-((Trifluoromethyl)thio)phenyl)ethanamine Related Literature

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