Production Method 1

856835-28-4

870971-19-0

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  80 min, reflux; reflux → 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 4, 0 °C

Reference

Discovery of Agonists of Cannabinoid Receptor 1 with Restricted Central Nervous System Penetration Aimed for Treatment of Gastroesophageal Reflux Disease

Plowright, Alleyn T.; et al, Journal of Medicinal Chemistry, 2013, 56(1), 220-240

Production Method 2

22282-96-8

870971-19-0

Reaction Conditions

1.1 Reagents: Nitrobenzene ,  Sodium hydroxide ,  Cobalt chloride (CoCl2) ,  Water Catalysts: Selenium Solvents: Dimethyl sulfoxide ;  5 h, 90 °C; 5 min, 90 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2.5

Reference

Selenium-catalyzed intramolecular atom- and redox-economical transformation of o-nitrotoluenes into anthranilic acids

Li, Yiming; et al, Green Chemistry, 2021, 23(8), 2986-2991

3-Amino-6-methoxy-2-pyridine carboxylicacid Raw materials

• 3-acetamido-6-methoxy-2-pyridinecarboxylic Acid
• 6-bromo-2-methyl-3-nitropyridine

3-Amino-6-methoxy-2-pyridine carboxylicacid Preparation Products

• 3-Amino-6-methoxy-2-pyridine carboxylicacid (870971-19-0)

• 1. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 2. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 3. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
  Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
• 4. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 5. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

3-Amino-6-Methoxy-2-Pyridine Carboxylic Acid: A Comprehensive Overview

3-Amino-6-methoxy-2-pyridine carboxylic acid, also known by its CAS number 870971-19-0, is a versatile organic compound with significant applications in various fields of chemistry and pharmacology. This compound belongs to the class of pyridine derivatives, which are widely studied due to their unique chemical properties and potential biological activities. The structure of 3-amino-6-methoxy-2-pyridine carboxylic acid consists of a pyridine ring substituted with an amino group at position 3, a methoxy group at position 6, and a carboxylic acid group at position 2. These functional groups confer the molecule with diverse reactivity and make it a valuable substrate for further chemical modifications.

Recent studies have highlighted the importance of 3-amino-6-methoxy-2-pyridine carboxylic acid in drug discovery and development. The presence of the amino and methoxy groups on the pyridine ring enhances the compound's ability to interact with biological targets, such as enzymes and receptors. For instance, researchers have explored its potential as a lead compound for designing inhibitors of kinase enzymes, which are crucial in various disease pathways, including cancer and inflammatory disorders. The carboxylic acid group provides additional functionality, enabling the formation of amide bonds with other molecules, thereby facilitating the creation of more complex structures with enhanced bioavailability.

In addition to its pharmacological applications, 3-amino-6-methoxy-2-pyridine carboxylic acid has found utility in materials science. Its ability to form coordination complexes with metal ions has been leveraged in the synthesis of novel materials for catalysis and sensing applications. For example, recent advancements have demonstrated its use as a ligand in constructing metal-organic frameworks (MOFs) that exhibit high surface area and selective adsorption properties. These materials hold promise for gas storage, separation, and catalytic processes.

The synthesis of 3-amino-6-methoxy-2-pyridine carboxylic acid typically involves multi-step organic reactions. A common approach includes the substitution of a suitable precursor pyridine derivative with an amino group followed by methylation and oxidation steps to introduce the methoxy and carboxylic acid functionalities. Researchers have optimized these reaction conditions to improve yield and purity, ensuring scalability for industrial applications.

From an environmental perspective, understanding the degradation pathways of 3-amino-6-methoxy-2-pyridine carboxylic acid is essential for assessing its ecological impact. Studies have shown that under aerobic conditions, the compound undergoes microbial degradation through enzymatic hydrolysis of its functional groups. This knowledge is critical for developing sustainable manufacturing processes and minimizing environmental risks associated with its production and use.

In conclusion, 3-amino-6-methoxy-2-pyridine carboxylic acid, CAS number 870971-19-0, stands as a testament to the versatility of pyridine derivatives in modern chemistry. Its unique structure enables diverse applications across drug discovery, materials science, and environmental chemistry. As research continues to uncover new insights into its properties and potential uses, this compound is poised to play an increasingly important role in advancing scientific innovation.

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• 21190-93-2(1-(6-methoxy-2-pyridyl)ethanone)
• 4434-13-3(5-methylpyridine-2-carboxylic acid)
• 19621-92-2(6-oxo-1,6-dihydropyridine-2-carboxylic acid)
• 5467-69-6(1-Ethyl-6-methyl-5-nitropyridin-2(1H)-one)
• 934-60-1(6-Methylpicolinic acid)
• 499-83-2(Pyridine-2,6-dicarboxylic acid)
• 15069-92-8(5-Hydroxypyridine-2-carboxylic acid)
• 4021-08-3(4-Methylpyridine-2-carboxylic Acid)