Production Method 1

108-48-5

934-60-1

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Water ;  300 min, 60 °C; 5 h, rt

Reference

A kind of polysubstituted pyridines medicine intermediate and the synthetic method thereof

, China, , ,

Production Method 2

108-48-5

934-60-1

Reaction Conditions

1.1 Reagents: Chromium trioxide

Reference

Liquid-phase oxidation of 2,6-lutidine and 2,4,6-collidine with sodium bichromate and chromium trioxide

Kreile, D.; Milman, I. A.; Eglite, D.; Krumina, L.; Sile, D.; et al, Zhurnal Prikladnoi Khimii (Sankt-Peterburg, 1978, 51(7), 1644-8

Production Method 3

108-48-5

934-60-1

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Cobalt diacetate ,  N-Hydroxyphthalimide ,  Manganese diacetate Solvents: Acetic acid

Reference

Preparation of carboxylic acids by oxidation with molecular oxygen

, Japan, , ,

Production Method 4

1620-75-3

934-60-1

Reaction Conditions

Reference

Picolinic or 6-methylpicolinic acids

, USSR, , ,

Production Method 5

108-48-5

934-60-1

Reaction Conditions

Reference

Synthesis and resolution of substituted pipecolic acids

Overberger, C. G.; Shalati, M. D., European Polymer Journal, 1983, 19(10-11), 1055-65

Production Method 6

934-60-1

Reaction Conditions

Reference

Syntheses of some amide and ester derivatives of 6-methyl-2-pyridinecarboxylic acid of expected activity on circulatory system

Gutkowska, Bozenna; Kabzinska, Zofia; Slowinski, Tomasz, Acta Poloniae Pharmaceutica, 1996, 53(2), 133-135

Production Method 7

934-60-1

Reaction Conditions

Reference

Active oxygen-inhibiting compositions containing picolinic acid compounds, electrolytes and other substances for organ preservation

, Japan, , ,

Production Method 8

934-60-1

116-53-0

4518-10-9

51-67-2

868-57-5

23950-04-1

13231-81-7

79491-14-8

83647-42-1

20282-39-7

Reaction Conditions

1.1 300 - 900 °C

Reference

Synthesis and pyrolysis of two novel pyrrole ester flavor precursors

Fan, Wenpeng ; et al, Journal of Heterocyclic Chemistry, 2022, 59(8), 1397-1406

Production Method 9

34034-36-1

934-60-1

116-53-0

4518-10-9

51-67-2

868-57-5

23950-04-1

13231-81-7

79491-14-8

83647-42-1

20282-39-7

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: Tetrabutylammonium bromide Solvents: Acetonitrile ;  17 h, 65 °C
2.1 Reagents: Sodium borohydride Solvents: Methanol ;  20 min, 0 °C
2.2 Reagents: Sodium chloride Solvents: Water ;  2 min
3.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide Solvents: Dichloromethane ;  1 h, rt
3.2 Catalysts: 4-(Dimethylamino)pyridine ;  24 h, rt
4.1 300 - 900 °C

Reference

Synthesis and pyrolysis of two novel pyrrole ester flavor precursors

Fan, Wenpeng ; et al, Journal of Heterocyclic Chemistry, 2022, 59(8), 1397-1406

Production Method 10

174293-65-3

934-60-1

Reaction Conditions

1.1 Reagents: Ammonium chloride Solvents: Water ;  10 min, 50 °C

Reference

Production of pyridine synthons by biotransformations of benzene precursors and their cyclization with nitrogen nucleophiles

Matthews, Colette; Rossiter, John T.; Ribbons, Douglas W.; Geary, Philip J.; Ryback, George; et al, Biocatalysis and Biotransformation, 1995, 12(4), 241-54

Production Method 11

934-60-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  rt → reflux; 25 min, reflux; reflux → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 1, rt

Reference

A long-range chiral relay via tertiary amide group in asymmetric catalysis: new amino acid-derived N,P-ligands for copper-catalysed conjugate addition

Malkov, Andrei V.; Hand, John B.; Kocovsky, Pavel, Chemical Communications (Cambridge, 2003, (15), 1948-1949

Production Method 12

1620-75-3

934-60-1

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  24 h, reflux

Reference

Smart contrast agents using cyclodextrin derivatives for MRI imaging

, World Intellectual Property Organization, , ,

Production Method 13

108-48-5

934-60-1

Reaction Conditions

1.1 Reagents: Oxygen Solvents: Water ;  54 h, pH 7, 30 °C
1.2 Reagents: Methanol

Reference

Bioconversion of 2,6-dimethylpyridine to 6-methylpicolinic acid by Exophiala dermatitidis (Kano) de Hoog DA5501 cells grown on n-dodecane

Yoshida, Toyokazu; Sada, Yuki; Nagasawa, Toru, Applied Microbiology and Biotechnology, 2010, 86(4), 1165-1170

Production Method 14

68470-59-7

934-60-1

Reaction Conditions

1.1 Reagents: Iodobenzene diacetate Catalysts: (SP-5-12)-Chloro[5,10,15,20-tetrakis(4-nitrophenyl)-21H,23H-porphinato(2-)-κN21,… Solvents: Methanol ,  Water ;  12 h, 50 °C

Reference

Preparation of 4,7-diphenyl-1,10-phenanthroline-2,9-dicarboxylic acid catalyzed by iron(III)porphyrins with (diacetoxyiodo)benzene

Zhong, Qi-Di; Xue, Yun-Zhou; Yan, Hong; Song, Xiu-Qing; Zhong, Ru-Gang, Bioorganic & Medicinal Chemistry Letters, 2010, 20(18), 5532-5535

Production Method 15

108-48-5

934-60-1

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Water ;  rt

Reference

Connecting Terminal Carboxylate Groups in Nine-Coordinate Lanthanide Podates: Consequences on the Thermodynamic, Structural, Electronic, and Photophysical Properties

Senegas, Jean-Michel; Bernardinelli, Gerald; Imbert, Daniel; Bunzli, Jean-Claude G.; Morgantini, Pierre-Yves; et al, Inorganic Chemistry, 2003, 42(15), 4680-4695

Production Method 16

934-60-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  1 h, 80 °C

Reference

Preparation of compounds for transforming growth factor receptor antagonists

, China, , ,

Production Method 17

108-48-5

934-60-1

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Water ;  rt → 70 °C; 70 °C; 5 h, 70 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 3.3

Reference

Preparation of aryl sulfonamides as antagonists of CCR9 receptor

, United States, , ,

Production Method 18

488-17-5

934-60-1

Reaction Conditions

1.1 -
1.2 Reagents: Ammonia Solvents: Water

Reference

Catechol 2,3-dioxygenase-catalyzed synthesis of picolinic acids from catechols

Asano, Yasuhisa; Yamamoto, Yasushi; Yamada, Hideaki, Bioscience, 1994, 58(11), 2954-6

Production Method 19

4593-07-1

934-60-1

Reaction Conditions

Reference

Pyridine derivatives

, Japan, , ,

Production Method 20

934-60-1

Reaction Conditions

Reference

Use of indazole compound for treating psoriasis

, World Intellectual Property Organization, , ,

Production Method 21

934-60-1

Reaction Conditions

Reference

Smart contrast agents for mri imaging

, United States, , ,

Production Method 22

934-60-1

Reaction Conditions

Reference

Preparation of heterocyclic carboxylic acids or ketones by oxidation of heterocyclic compounds

, Japan, , ,

Production Method 23

65-85-0

934-60-1

116-53-0

4518-10-9

51-67-2

868-57-5

23950-04-1

13231-81-7

79491-14-8

83647-42-1

20282-39-7

Reaction Conditions

1.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide Solvents: Dichloromethane ;  1 h, rt
1.2 Catalysts: 4-(Dimethylamino)pyridine ;  24 h, rt
2.1 300 - 900 °C

Reference

Synthesis and pyrolysis of two novel pyrrole ester flavor precursors

Fan, Wenpeng ; et al, Journal of Heterocyclic Chemistry, 2022, 59(8), 1397-1406

Production Method 24

934-60-1

116-53-0

4518-10-9

51-67-2

868-57-5

23950-04-1

13231-81-7

79491-14-8

83647-42-1

20282-39-7

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Methanol ;  20 min, 0 °C
1.2 Reagents: Sodium chloride Solvents: Water ;  2 min
2.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide Solvents: Dichloromethane ;  1 h, rt
2.2 Catalysts: 4-(Dimethylamino)pyridine ;  24 h, rt
3.1 300 - 900 °C

Reference

Synthesis and pyrolysis of two novel pyrrole ester flavor precursors

Fan, Wenpeng ; et al, Journal of Heterocyclic Chemistry, 2022, 59(8), 1397-1406

Production Method 25

934-60-1

116-53-0

4518-10-9

51-67-2

868-57-5

23950-04-1

13231-81-7

79491-14-8

83647-42-1

20282-39-7

Reaction Conditions

1.1 300 - 900 °C
2.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide Solvents: Dichloromethane ;  1 h, rt
2.2 Catalysts: 4-(Dimethylamino)pyridine ;  24 h, rt
3.1 300 - 900 °C

Reference

Synthesis and pyrolysis of two novel pyrrole ester flavor precursors

Fan, Wenpeng ; et al, Journal of Heterocyclic Chemistry, 2022, 59(8), 1397-1406

Production Method 26

116-53-0

934-60-1

116-53-0

4518-10-9

51-67-2

868-57-5

23950-04-1

13231-81-7

79491-14-8

83647-42-1

20282-39-7

Reaction Conditions

1.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide Solvents: Dichloromethane ;  1 h, rt
1.2 Catalysts: 4-(Dimethylamino)pyridine ;  24 h, rt
2.1 300 - 900 °C
3.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide Solvents: Dichloromethane ;  1 h, rt
3.2 Catalysts: 4-(Dimethylamino)pyridine ;  24 h, rt
4.1 300 - 900 °C

Reference

Synthesis and pyrolysis of two novel pyrrole ester flavor precursors

Fan, Wenpeng ; et al, Journal of Heterocyclic Chemistry, 2022, 59(8), 1397-1406

Production Method 27

33302-94-2

934-60-1

116-53-0

4518-10-9

51-67-2

868-57-5

23950-04-1

13231-81-7

79491-14-8

83647-42-1

20282-39-7

Reaction Conditions

1.1 Reagents: Sodium periodate Solvents: Water ;  10 min, rt
2.1 Reagents: Potassium carbonate Catalysts: Tetrabutylammonium bromide Solvents: Acetonitrile ;  17 h, 65 °C
3.1 Reagents: Sodium borohydride Solvents: Methanol ;  20 min, 0 °C
3.2 Reagents: Sodium chloride Solvents: Water ;  2 min
4.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide Solvents: Dichloromethane ;  1 h, rt
4.2 Catalysts: 4-(Dimethylamino)pyridine ;  24 h, rt
5.1 300 - 900 °C

Reference

Synthesis and pyrolysis of two novel pyrrole ester flavor precursors

Fan, Wenpeng ; et al, Journal of Heterocyclic Chemistry, 2022, 59(8), 1397-1406

Production Method 28

66-84-2

934-60-1

116-53-0

4518-10-9

51-67-2

868-57-5

23950-04-1

13231-81-7

79491-14-8

83647-42-1

20282-39-7

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Water ;  24 h, rt
2.1 Reagents: Sodium periodate Solvents: Water ;  10 min, rt
3.1 Reagents: Potassium carbonate Catalysts: Tetrabutylammonium bromide Solvents: Acetonitrile ;  17 h, 65 °C
4.1 Reagents: Sodium borohydride Solvents: Methanol ;  20 min, 0 °C
4.2 Reagents: Sodium chloride Solvents: Water ;  2 min
5.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide Solvents: Dichloromethane ;  1 h, rt
5.2 Catalysts: 4-(Dimethylamino)pyridine ;  24 h, rt
6.1 300 - 900 °C

Reference

Synthesis and pyrolysis of two novel pyrrole ester flavor precursors

Fan, Wenpeng ; et al, Journal of Heterocyclic Chemistry, 2022, 59(8), 1397-1406

6-Methylpicolinic acid Raw materials

• 3-Methylcatechol
• 2-Methylbutanoic acid
• methyl 5-formyl-2-methyl-1H-pyrrole-3-carboxylate
• Benzoic acid
• 1H-Pyrrole-3-carboxylic acid, 2-methyl-5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-, methyl ester
• 2,4-Heptadienoic acid, 2-hydroxy-6-oxo-, (E,Z)-
• 2-(Bromomethyl)-6-methylpyridine
• 2-cyano-6-methylpyridine
• Cap B2 Solution [2,6-Lutidine-Acetonitrile (6:4)]
• Glucosamine hydrochloride
• 2-Pyridinecarbothioamide, 6-methyl-N-phenyl-

6-Methylpicolinic acid Preparation Products

• 2-Methylbutanoic acid (116-53-0)
• Methyl 3-aminobenzoate (4518-10-9)
• p-Tyramine (51-67-2)
• DL-2-Methylbutyric Acid Methyl Ester (868-57-5)
• 6-Methylpicolinic acid (934-60-1)
• o-Nicotine (23950-04-1)
• 3-Methyl-1-hexanol (13231-81-7)
• 1H-Pyrrole-3-propanoic acid, 4-acetyl-5-methyl-, methyl ester (79491-14-8)
• 3-Amino-2-methyl-benzyl Alcohol (83647-42-1)
• 2,5-dimethyl-1-propyl-1H-pyrrole (20282-39-7)

• 1. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 2. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
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• 3. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 4. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 5. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Heterocyclic Compounds

Comprehensive Overview of 6-Methylpicolinic Acid (CAS No. 934-60-1): Properties, Applications, and Industry Insights

6-Methylpicolinic acid (CAS No. 934-60-1), a derivative of picolinic acid, is a versatile organic compound with a growing presence in pharmaceutical, agrochemical, and specialty chemical industries. Its molecular structure, featuring a methyl group at the 6-position of the pyridine ring, enhances its reactivity and utility in synthesis. As demand for heterocyclic compounds surges, researchers and manufacturers are increasingly focusing on 6-Methylpicolinic acid applications in drug intermediates and catalysis.

The compound’s physicochemical properties include a molecular formula of C₇H₇NO₂, a white to off-white crystalline appearance, and solubility in polar solvents like water and ethanol. These traits make it ideal for fine chemical synthesis, particularly in designing bioactive molecules. Recent studies highlight its role in developing metal-chelating agents, addressing trends in sustainable chemistry and green synthesis—topics frequently searched in academic and industrial forums.

In pharmaceuticals, 6-Methylpicolinic acid serves as a precursor for antimicrobial agents and enzyme inhibitors. Its pyridine core is pivotal in constructing nitrogen-containing heterocycles, a hotspot in drug discovery. For instance, it’s explored in neurological research due to potential interactions with neurotransmitter pathways, aligning with rising interest in CNS-targeted therapies.

Agrochemical applications leverage its chelating properties to enhance micronutrient delivery in fertilizers. This aligns with the precision agriculture trend, where users often search for eco-friendly crop solutions. Additionally, its stability under moderate conditions makes it suitable for formulation additives in pesticide adjuvants.

From an industrial perspective, CAS No. 934-60-1 is gaining traction in coordination chemistry for crafting ligands used in catalytic systems. This ties into the broader renewable energy discourse, as researchers investigate its role in hydrogen storage and CO₂ reduction catalysts—keywords frequently queried in materials science databases.

Quality control of 6-Methylpicolinic acid involves HPLC analysis and spectroscopic characterization (e.g., NMR, IR), ensuring compliance with pharmacopeial standards. Suppliers emphasize high-purity grades (>98%) to meet GMP requirements, a critical consideration for contract manufacturing organizations (CMOs).

Emerging discussions on circular economy and waste valorization have spurred interest in 6-Methylpicolinic acid recycling from industrial byproducts. Innovations in biocatalytic production further align with carbon-neutral goals, resonating with ESG-focused investors.

In summary, 6-Methylpicolinic acid (CAS No. 934-60-1) exemplifies the intersection of traditional chemistry and modern sustainability. Its multifaceted applications—from life sciences to industrial catalysis—position it as a compound of enduring relevance, driven by evolving market demands and technological advancements.

• 98-98-6(Picolinic acid)
• 8008-52-4(CORIANDER OIL)
• 17956-40-0(2,6-Pyridinedicarboxylicacid, sodium salt (1:2))
• 32075-31-3(Pyridinecarboxylic acid)
• 1197-10-0(6-(Hydroxymethyl)picolinic acid)
• 307531-73-3(2-Pyridinecarboxylicacid, 6-methyl-, hydrochloride, hydrate (1:1:1))
• 499-83-2(Pyridine-2,6-dicarboxylic acid)
• 25108-36-5(2-Pyridinecarboxylicacid, potassium salt (1:1))
• 104571-39-3(Cuprate(1-),[2,6-pyridinedicarboxylato(2-)-N1,O2,O6](2-pyridinecarboxylato-N1,O2)-,hydrogen (9CI))
• 64059-35-4(Thiazolamine,N-ethyl-N-phenyl- (9CI))