Cas no 870-46-2 ((tert-butoxy)carbohydrazide)

(tert-Butoxy)carbohydrazide is a versatile hydrazide derivative widely used in organic synthesis and pharmaceutical applications. Its key advantages include high reactivity as a hydrazine precursor, enabling efficient formation of hydrazones and other nitrogen-containing compounds. The tert-butoxy group enhances stability, facilitating handling and storage compared to more labile hydrazides. This compound is particularly valuable in peptide coupling, heterocycle synthesis, and as a building block for agrochemicals and pharmaceuticals. Its selective reactivity allows for controlled transformations under mild conditions, minimizing side reactions. (tert-Butoxy)carbohydrazide is also employed in crosslinking reactions and polymer modification, offering a balance between reactivity and stability for specialized synthetic routes.
(tert-butoxy)carbohydrazide structure
(tert-butoxy)carbohydrazide structure
Product Name:(tert-butoxy)carbohydrazide
CAS No:870-46-2
MF:C5H12N2O2
MW:132.160981178284
MDL:MFCD00007593
CID:40104
PubChem ID:70091
Update Time:2025-10-30

(tert-butoxy)carbohydrazide Chemical and Physical Properties

Names and Identifiers

    • tert-Butyl carbazate
    • Butylcarbazate
    • BOC-hydrazide
    • t-Butyloxycarbonyl-hydrazide
    • Boc-hydrazine
    • tert-Butoxycarbonylhydrazine
    • tert-Butyl hydrazinocarboxylate
    • tert.-Butylcarbazate
    • Hydrazinoformic acid tert-butyl ester
    • Hydrazine carboxylic acid T-butyl
    • Tert-Butyloxycarbonyl-hydrazide
    • tert-Butyl hydrazinoformate
    • T00041
    • Hydrazinecarboxylic acid tert-butyl ester
    • t-Butyl Carbazate
    • tert-Butyl hydrazinecarboxylate
    • tert-butyl N-aminocarbamate
    • tert-Butoxycarbonyl hydrazide
    • Carbazic Acid tert-Butyl Ester
    • (tert-butoxy)carbohydrazide
    • Carbazic acid, tert-butyl ester (6CI, 8CI)
    • (tert-Butoxycarbonyl)hydrazide
    • (tert-Butoxycarbonyl)hydrazine
    • (tert-Butyloxycarbonyl)hydrazide
    • 1,1-Dimethylethyl carbazate
    • 1,1-Dimethylethyl hydrazinecarboxylate
    • 1-(tert-Butoxycarbonyl)hydrazine
    • Hydrazinecarboxylic acid tert-butyl ester
    • N-(tert-Butoxycarbonyl)hydrazine
    • N-Boc-hydrazine
    • NSC 60250
    • AI3-62061
    • NS00039165
    • t-Butyloxycarbonylhydrazine
    • CS-W008846
    • tert-butoxycarbonyl hydrazine
    • STK074844
    • AKOS000119499
    • 1.0M in dichloromethane
    • PB18405
    • DTXSID7061227
    • tert-butyl-1-hydrazinecarboxylate
    • Boc hydrazine
    • tert. butyl hydrazinoformate
    • N-[(t-Butyloxy)carbonyl]hydrazine
    • tertbutoxycarbonylhydrazine
    • tert-butylhydrazine carboxylate
    • HYDRAZINE CARBOXYLIC ACID TERT-BUTYL ESTER
    • BCP22479
    • Tert-Butyl carbazate;Hydrazinecarboxylicacid,1,1-dimethylethylester
    • (t-butoxycarbonyl)hydrazine
    • hydrazinecarboxylic acid t-butyl ester
    • monoBOC-hydrazine
    • hydrazinecarboxylic acid tert.-butyl ester
    • hydrazine carboxylic acid, 1,1-dimethylethyl ester
    • 870-46-2
    • tert.butyl carbazate
    • Hydrazinecarboxylic acid, tert-butyl ester
    • tert-butyl-carbazate
    • NSC60250
    • tert-Butyloxycarbonylhydrazide
    • teri-butyl carbazate
    • carbazi acid tert-butyl ester
    • NSC-60250
    • tert-Butyl carbazate solution
    • SCHEMBL6237
    • AS-13557
    • Hydrazinecarboxylic acid, 1,1-dimethylethyl ester
    • 1-Boc hydrazine(BOC-NHNH2)
    • t-butoxycarbonylhydrazine
    • tert-butyl hydrazine carboxylate
    • tert-butyl hydrazine-carboxylate
    • Carbazic acid, tert-butyl ester
    • tert-Butyl carbazate, purum, >=98.0% (GC)
    • t-butyl-carbazate
    • MFCD00007593
    • hydrazinecarboxylic acid tert-butylester
    • NH2NHBoc
    • DTXCID0048559
    • BocNHNH2
    • DZ6ERH52CN
    • EN300-20397
    • Hydrazinecarboxylic acid,1-dimethylethyl ester
    • EINECS 212-795-3
    • t-butlycarbazate
    • N-(t-butoxycarbonyl)hydrazine
    • BBL012740
    • iert-butyl carbazate
    • tertbutylcarbazate
    • W-104045
    • BP-10091
    • F0001-2166
    • tert-Butylcarbazate
    • t-Butylcarbazate
    • tert-Butyl carbazate, 98%
    • tert-butylhydrazinecarboxylate
    • t-butyl hydrazinecarboxylate
    • N-amino-carbamic acid tert-butyl ester
    • MDL： MFCD00007593
    • Inchi： 1S/C5H12N2O2/c1-5(2,3)9-4(8)7-6/h6H2,1-3H3,(H,7,8)
    • InChI Key： DKACXUFSLUYRFU-UHFFFAOYSA-N
    • SMILES： O=C(NN)OC(C)(C)C
    • BRN： 1756967

Computed Properties

  • Exact Mass: 132.09000
  • Monoisotopic Mass: 132.09
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 9
  • Rotatable Bond Count: 3
  • Complexity: 106
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 64.4A^2
  • Surface Charge: 0
  • Tautomer Count: 2
  • XLogP3: 0.2

Experimental Properties

  • Color/Form: White to yellowish crystalline block
  • Density: 1.290?g/mL
  • Melting Point: 39.0 to 43.0 deg-C
  • Boiling Point: 95°C/10mmHg(lit.)
  • Flash Point: Fahrenheit: 197.6 ° f < br / > Celsius: 92 ° C < br / >
  • Refractive Index: n/D 1.427
  • Solubility: Soluble in ethanol and methanol.
  • PSA: 64.35000
  • LogP: 1.47600
  • Solubility: Not determined
  • Vapor Pressure: 0.0±0.9 mmHg at 25°C
  • Sensitiveness: Moisture Sensitive
  • Color/Form: 1.0?M in dichloromethane

(tert-butoxy)carbohydrazide Security Information

  • Symbol: GHS02
  • Prompt：warning
  • Signal Word：Warning
  • Hazard Statement： H228
  • Warning Statement： P210,P241,P280,P240,P370+P378
  • Hazardous Material transportation number：1325
  • WGK Germany：3
  • Hazard Category Code： R11;R24/25;R36/37/38;R48
  • Safety Instruction： S45-S36/37/39-S16
  • FLUKA BRAND F CODES：21
  • Hazardous Material Identification： F T
  • Safety Term：4.1
  • Packing Group：III
  • Risk Phrases：R11; R24/25; R36/37/38; R48
  • HazardClass：4.1
  • PackingGroup：III
  • TSCA：Yes
  • Storage Condition：Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

(tert-butoxy)carbohydrazide Customs Data

  • HS CODE：29280090
  • Customs Data：

    China Customs Code:

    29280090

(tert-butoxy)carbohydrazide Pricemore >>

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(tert-butoxy)carbohydrazide Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Hydrazine
Reference
tert-Butyl carbazate
Carpino, Louis A.; et al, Organic Syntheses, 1964, 44, 20-5

Production Method 2

Reaction Conditions
1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Water ;  80 °C → 100 °C; 1 h, 100 °C
1.2 Solvents: Chloroform ;  3 h
1.3 Reagents: Sodium hydroxide Solvents: Water ;  25 - 30 °C
Reference
Study on tert-butyl carbazate synthesis
Xu, Dongchao; et al, Huagong Jinzhan, 2011, 30(11), 2528-2531

Production Method 3

Reaction Conditions
1.1 Reagents: Chlorotrimethylsilane ,  Misch metal Solvents: Tetrahydrofuran ;  20 - 30 min, reflux
1.2 2 h, reflux
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized
Reference
A selective method for cleavage of N-Troc-protected hydrazines and amines under mild conditions using mischmetal and TMSCl
Vellemae, Eerold; et al, Journal of Chemical Research, 2006, (11), 685-687

Production Method 4

Reaction Conditions
1.1 Reagents: Hydrazine Solvents: Dichloromethane
Reference
Syntheses and antitumor activities of N'1,N'3-dialkyl-N'1,N'3-di-(alkylcarbonothioyl) malonohydrazide: The discovery of elesclomol
Chen, Shoujun; et al, Bioorganic & Medicinal Chemistry Letters, 2013, 23(18), 5070-5076

Production Method 5

Reaction Conditions
1.1 Reagents: Hydrazine Solvents: Isopropanol ;  0 °C; 2 h, 0 °C
Reference
Mimicking a proline tripeptide with pyrazolidines and a cyclopentane linker
Vertesaljai, Peter; et al, Tetrahedron Letters, 2015, 56(48), 6653-6655

Production Method 6

Reaction Conditions
1.1 Reagents: Pyridine Solvents: Chloroform ;  1 h, 28 - 31 °C; 3 h
1.2 Reagents: Water
2.1 Reagents: Hydrazine hydrate (1:1) Solvents: Water ;  80 °C → 100 °C; 1 h, 100 °C
2.2 Solvents: Chloroform ;  3 h
2.3 Reagents: Sodium hydroxide Solvents: Water ;  25 - 30 °C
Reference
Study on tert-butyl carbazate synthesis
Xu, Dongchao; et al, Huagong Jinzhan, 2011, 30(11), 2528-2531

Production Method 7

Reaction Conditions
1.1 Reagents: Hydrazine Solvents: Water ;  rt
Reference
N-Aminophthalimide
Krasnova, Larissa B.; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2004, 1, 1-5

Production Method 8

Reaction Conditions
Reference
Product class 7: hydrazines and hydrazinium salts
Rademacher, P., Science of Synthesis, 2009, 40, 1133-1210

Production Method 9

Reaction Conditions
1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Tetrahydrofuran ;  rt
2.1 Reagents: Hydrazine Solvents: Water ;  rt
Reference
N-Aminophthalimide
Krasnova, Larissa B.; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2004, 1, 1-5

Production Method 10

Reaction Conditions
1.1 Reagents: Hydrazine
Reference
Synthesis of a non-symmetric azodicarbonyl compound and its regioselective reaction with organometallic reagents
Yamamoto, Yoshinori; et al, Tetrahedron Letters, 1991, 32(26), 3079-82

Production Method 11

Reaction Conditions
1.1 Reagents: Hydrazine hydrate (1:1) Solvents: 1,4-Dioxane ;  0 °C; 12 h, rt
Reference
Discovery of potent inhibitors of human β-tryptase from pre-equilibrated dynamic combinatorial libraries
Jiang, Qian-Qian; et al, Chemical Science, 2015, 6(3), 1792-1800

Production Method 12

Reaction Conditions
1.1 Reagents: Sulfuric acid Solvents: Methanol ,  Water ;  4 h, reflux; reflux → rt
1.2 Reagents: Hydrazine hydrate (1:1) Solvents: Water ;  30 min, reflux
Reference
Designing and exploring active N'-[(5-nitrofuran-2-yl)methylene] substituted hydrazides against three Trypanosoma cruzi strains more prevalent in Chagas disease patients
Palace-Berl, Fanny ; et al, European Journal of Medicinal Chemistry, 2015, 96, 330-339

Production Method 13

Reaction Conditions
1.1 Reagents: Hydrazine
Reference
tert-Butyloxycarbonylimidazole and tert-butyloxycarbonylhydrazine
Klee, W.; et al, Helvetica Chimica Acta, 1950, 44, 2151-3

Production Method 14

Reaction Conditions
1.1 Reagents: Hydrazine
Reference
tert-Butyl carbazate
Carpino, Louis A.; et al, Organic Syntheses, 1964, 44, 20-5

Production Method 15

Reaction Conditions
1.1 Reagents: Pyridine Solvents: Dichloromethane ;  rt → 0 °C
1.2 Solvents: Dichloromethane ;  0 °C → rt; overnight, rt
1.3 Reagents: Hydrochloric acid Solvents: Water
2.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ;  1 h, 80 °C
2.2 Reagents: Sodium hydroxide Solvents: Water
Reference
Fluoroamide-driven intermolecular hydrogen-atom-transfer-enabled intermolecular 1,2-alkylarylation of alkenes
Cheng, Chaozhihui; et al, Organic Chemistry Frontiers, 2023, 10(4), 943-950

Production Method 16

Reaction Conditions
1.1 Catalysts: Hydrazine Solvents: Diethyl ether ;  -60 °C
Reference
t-Butyl Chloroformate
Sennyey, G., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, ,

Production Method 17

Reaction Conditions
1.1 Reagents: Hydrazine Solvents: Diethyl ether ,  tert-Butanol
Reference
A new convenient method for the synthesis of tert-butyloxy-carbonylhydrazine
Ovchinnikov, Yu. A.; et al, Experientia, 1965, 21(7), 418-19

Production Method 18

Reaction Conditions
1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Isopropanol ;  2 h, 0 °C; overnight, rt
Reference
A Novel Poly(L-glutamic acid) Dendrimer Based Drug Delivery System with Both pH-Sensitive and Targeting Functions
Yuan, Hui; et al, Molecular Pharmaceutics, 2010, 7(4), 953-962

Production Method 19

Reaction Conditions
1.1 Catalysts: Hydrazine Solvents: Water ;  22 °C
Reference
N-Aminophthalimide
Krasnova, Larissa B.; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, ,

Production Method 20

Reaction Conditions
Reference
Product class 7: hydrazines and hydrazinium salts
Rademacher, P., Science of Synthesis, 2009, 40, 1133-1210

(tert-butoxy)carbohydrazide Raw materials

(tert-butoxy)carbohydrazide Preparation Products

(tert-butoxy)carbohydrazide Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:870-46-2)tert-Butylhydrazinoformate
Order Number:LE18093;LE4871;LE1709765
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:17
Price ($):discuss personally
Amadis Chemical Company Limited
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(CAS:870-46-2)(tert-butoxy)carbohydrazide
Order Number:A1204122
Stock Status:in Stock
Quantity:1kg
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 02:52
Price ($):423.0
Suzhou Senfeida Chemical Co., Ltd
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(CAS:870-46-2)tert-Butyl carbazate
Order Number:sfd21641
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:39
Price ($):discuss personally

(tert-butoxy)carbohydrazide Spectrogram

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GC-MS
1H NMR 300 MHz DMSO
1H NMR
13C NMR
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(tert-butoxy)carbohydrazide Related Literature

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870-46-2 ((tert-butoxy)carbohydrazide) Related Products

Recommended suppliers
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:870-46-2)tert-Butylhydrazinoformate
LE18093;LE4871;LE1709765
Purity:99%/99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry/Inquiry
Email
Amadis Chemical Company Limited
(CAS:870-46-2)(tert-butoxy)carbohydrazide
A1204122
Purity:99%
Quantity:1kg
Price ($):423.0
Email