• 1. An interplay between electronic and structural effects on the photoluminescence decay mechanisms in LaPO4·nH2O:Tb3+ and LaPO4:Tb3+ single-crystal nanorods?
  M. T. Colomer,S. Díaz-Moreno,A. Tamayo,A. L. Ortiz J. Mater. Chem. C, 2018,6, 12643-12651
• 2. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
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• 3. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
• 4. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 5. Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations
  Benjamin Gabriel Poulson,Kacper Szczepski,Joanna Izabela Lachowicz,Lukasz Jaremko,Abdul-Hamid Emwas,Mariusz Jaremko RSC Adv., 2020,10, 215-227

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenoxy compounds
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Recent Advances in the Application of Tert-Butyl Phenyl Carbonate (CAS 6627-89-0) in Chemical Biology and Pharmaceutical Research

Tert-Butyl phenyl carbonate (CAS 6627-89-0) has recently emerged as a versatile reagent in chemical biology and pharmaceutical synthesis. This compound, characterized by its tert-butyloxycarbonyl (Boc) protecting group attached to a phenyl carbonate moiety, has shown significant utility in organic synthesis, particularly in the protection of amines and hydroxyl groups. Recent studies have highlighted its role in the development of novel drug candidates and its application in peptide synthesis, where it serves as an efficient protecting group that can be removed under mild acidic conditions.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the effectiveness of Tert-Butyl phenyl carbonate in the synthesis of protease inhibitors. The researchers utilized this reagent to protect key amino groups during the synthesis of novel HIV-1 protease inhibitors, achieving higher yields and improved purity compared to traditional protection methods. The study also noted the compound's stability under various reaction conditions, making it particularly valuable for multi-step synthetic processes.

In the field of prodrug development, recent research has explored the potential of Tert-Butyl phenyl carbonate as a promoiety for phenolic drugs. A 2024 publication in Bioorganic & Medicinal Chemistry Letters reported on its use in creating carbonate prodrugs of phenolic compounds, which showed enhanced solubility and improved pharmacokinetic properties. The study found that the tert-butyl carbonate group could be efficiently cleaved by esterases in vivo, releasing the active drug molecule while maintaining good stability in the gastrointestinal tract.

From a safety and toxicological perspective, new data has emerged regarding the handling and storage of Tert-Butyl phenyl carbonate. A 2023 safety assessment published in Chemical Research in Toxicology confirmed its relatively low acute toxicity (LD50 > 2000 mg/kg in rats) but noted the importance of proper ventilation when handling the compound in powder form due to potential respiratory irritation. These findings have important implications for industrial-scale pharmaceutical manufacturing processes utilizing this reagent.

Recent advances in green chemistry have also incorporated Tert-Butyl phenyl carbonate as an environmentally benign alternative to more hazardous carbonate-forming reagents. A 2024 study in Green Chemistry demonstrated its use in solvent-free reactions for carbonate formation, achieving high atom economy and reducing waste generation. The researchers highlighted the compound's potential to contribute to more sustainable pharmaceutical manufacturing processes.

Looking forward, the unique properties of Tert-Butyl phenyl carbonate (CAS 6627-89-0) position it as a valuable tool in the development of next-generation therapeutics. Its dual functionality as both a protecting group and a prodrug moiety, combined with its favorable safety profile and synthetic versatility, suggest it will continue to play an important role in pharmaceutical research and development. Ongoing studies are exploring its applications in targeted drug delivery systems and as a component of self-immolative linkers in antibody-drug conjugates.

• 74805-99-5( )
• 920967-22-2(Carbonic acid, 1-methylethyl phenoxymethyl ester)
• 95932-39-1(4-aminophenyl tert-butyl carbonate)
• 13183-16-9(Carbonic acid, phenyl propyl ester)
• 7504-71-4( )
• 943-57-7(Carbonic acid, 1-methylethyl phenyl ester)
• 920967-23-3(Carbonic acid, 1,1-dimethylethyl phenoxymethyl ester)
• 7504-72-5(Carbonic acid,o-phenylene diisopropyl ester (8CI))
• 22719-84-2(Carbonic acid, ethyl4-methoxyphenyl ester)
• 104741-75-5(Carbonic acid, 1,1-dimethylethyl 4-methylphenyl ester)