Production Method 1

81-25-4

56-40-6

863-57-0

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline Solvents: Dimethyl sulfoxide ,  Acetonitrile ,  tert-Butanol ,  Water ;  10 min, 80 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 3

Reference

Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts

Venturoni, Francesco; et al, Organic & Biomolecular Chemistry, 2012, 10(20), 4109-4115

Sodium Glycocholate Raw materials

• Cholic acid
• Glycine

Sodium Glycocholate Preparation Products

• Sodium Glycocholate (863-57-0)

• 1. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324
• 2. Aggregation, pretransitional behavior, and optical properties in the isotropic phase of lyotropic chromonic liquid crystals studied in high magnetic fields
  Tanya Ostapenko,Peter J. Collings,Samuel N. Sprunt,J. T. Gleeson Soft Matter, 2013,9, 9487-9498
• 3. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
  Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
• 4. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126
• 5. An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting?
  Lab Chip, 2019,19, 524-535

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Steroids and steroid derivatives Hydroxy bile acids, alcohols and derivatives
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Steroids and steroid derivatives Bile acids, alcohols and derivatives Hydroxy bile acids, alcohols and derivatives

Sodium Glycocholate: A Comprehensive Overview

Sodium glycocholate, also known as sodium glycochenodeoxycholate, is a bile acid derivative with the CAS number 863-57-0. It is widely recognized for its role in various pharmaceutical and cosmetic applications. This compound is derived from glycocholic acid, a naturally occurring bile acid, and is often used in its sodium salt form due to its enhanced solubility and stability.

Sodium glycocholate has been extensively studied for its ability to form mixed micelles with phospholipids and cholesterol, making it an essential component in bile acid-based drug delivery systems. Recent research has highlighted its potential in enhancing the bioavailability of poorly soluble drugs by forming stable micellar structures that facilitate drug absorption in the gastrointestinal tract. This property has led to its increasing use in the development of nanotechnology-based drug delivery systems, such as liposomes and nanoparticles.

In the cosmetic industry, sodium glycocholate is valued for its surfactant properties. It is commonly used as an emulsifier and cleansing agent in skincare products, particularly those designed for sensitive skin. Its mild nature makes it suitable for formulations aimed at reducing skin irritation while maintaining effective cleansing performance. Studies have shown that sodium glycocholate can help maintain the skin's natural barrier function, making it a popular choice in anti-aging and moisturizing products.

One of the most recent advancements involving sodium glycocholate is its application in targeted drug delivery systems. Researchers have explored its ability to encapsulate therapeutic agents within micellar structures, enabling controlled release and improved targeting of specific tissues or cells. This innovation has significant implications for the treatment of chronic diseases, where precise drug delivery is crucial for efficacy and reduced side effects.

Moreover, sodium glycocholate has been investigated for its potential in treating certain liver diseases. Bile acids play a critical role in maintaining liver health, and sodium glycocholate has shown promise in managing conditions such as primary biliary cholangitis (PBC) and non-alcoholic fatty liver disease (NAFLD). Clinical trials have demonstrated that it can improve liver function markers and reduce inflammation, making it a promising therapeutic agent in hepatology.

The environmental impact of sodium glycocholate has also come under scrutiny in recent years. As concerns about biodegradability and eco-friendly product formulations grow, researchers are exploring ways to optimize its production processes to minimize ecological footprint. Advances in green chemistry have led to the development of more sustainable methods for synthesizing sodium glycocholate, ensuring that it remains a viable option for both industrial and medical applications without compromising environmental health.

In conclusion, sodium glycocholate (CAS No: 863-57-0) is a versatile compound with a wide range of applications across pharmaceuticals, cosmetics, and biotechnology. Its unique properties, combined with ongoing research into novel uses and sustainable production methods, position it as a key ingredient in modern formulations. As scientific understanding of this compound continues to evolve, so too will its role in advancing healthcare and personal care solutions.

• 475-31-0(Glycocholic acid)
• 2273-95-2(Glycine, N-[(3a,5b,7b)-3,7-dihydroxy-24-oxocholan-24-yl]-)
• 13042-33-6(Glycohyodeoxycholic Acid Standard)
• 207614-05-9(Glycocholic acid sodium salt hydrate)
• 360-65-6(Glycodeoxycholic acid monohydrate)
• 16409-34-0(Glycodeoxycholic Acid Sodium Salt)
• 52632-27-6(Glycine-1-14C, N-[(3a,5b,7a,12a)-3,7,12-trihydroxy-24-oxocholan-24-yl]-(9CI))
• 16564-43-5(Glycochenodeoxycholic Acid SodiuM Salt)
• 13164-18-6(Glykodeoxycholsaeure)
• 338950-81-5(Glycocholic Acid Hydrate Sodium Salt)