Cas no 86060-93-7 (Fmoc-Tyr(tBu)-OPfp)

Fmoc-Tyr(tBu)-OPfp structure
Fmoc-Tyr(tBu)-OPfp structure
Product Name:Fmoc-Tyr(tBu)-OPfp
CAS No:86060-93-7
MF:C34H28F5NO5
MW:625.581847190857
CID:720781
PubChem ID:57650960
Update Time:2024-10-26

Fmoc-Tyr(tBu)-OPfp Chemical and Physical Properties

Names and Identifiers

    • L-Tyrosine,O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-,2,3,4,5,6-pentafluorophenyl ester
    • N-Fmoc-O-tert-butyl-L-tyrosine pentafluorophenyl ester
    • Fmoc-L-Tyr(tBu)-opfp
    • Fmoc-Tyr(tBu)-OPfp
    • H-Ser(tBu)-OMe?HCl
    • L-Tyrosine,O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-,2,3,4,5,6-pentafluoroph...
    • L-Tyrosine, O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, pentafluorophenyl ester (9CI)
    • O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-tyrosine 2,3,4,5,6-pentafluorophenyl ester (ACI)
    • (2,3,4,5,6-Pentafluorophenyl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoate
    • N-9-Fluorenylmethoxycarbonyl-O-tert-butyltyrosine pentafluorophenyl ester
    • AKOS015902560
    • AKOS015853406
    • C34H28F5NO5
    • Pentafluorophenyl O-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-tyrosinate
    • 125043-03-0
    • SCHEMBL1739184
    • (S)-Perfluorophenyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butoxy)phenyl)propanoate
    • N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-tyrosine pentafluorphenyl ester
    • 86060-93-7
    • ADOSTZDWXCEVJP-VWLOTQADSA-N
    • Fmoc-O-tert-butyl-L-tyrosine pentafluorophenyl ester
    • 2,3,4,5,6-pentafluorophenyl (2S)-3-[4-(tert-butoxy)phenyl]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoate
    • AS-57080
    • Fmoc-Tyr(tBu)-OPfp, >=96.0% (HPLC)
    • HY-W008659
    • (S)-perfluorophenyl 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoate
    • MFCD00077077
    • DTXSID70447069
    • F87458
    • Fmoc-O-T-Butyl-L-Tyrosine Pentafluorophenyl Ester
    • CS-W009375
    • 2,3,4,5,6-PENTAFLUOROPHENYL (2S)-3-[4-(TERT-BUTOXY)PHENYL]-2-{[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO}PROPANOATE
    • DA-53367
    • MDL: MFCD00077077
    • Inchi: 1S/C34H28F5NO5/c1-34(2,3)45-19-14-12-18(13-15-19)16-25(32(41)44-31-29(38)27(36)26(35)28(37)30(31)39)40-33(42)43-17-24-22-10-6-4-8-20(22)21-9-5-7-11-23(21)24/h4-15,24-25H,16-17H2,1-3H3,(H,40,42)/t25-/m0/s1
    • InChI Key: ADOSTZDWXCEVJP-VWLOTQADSA-N
    • SMILES: C(C1C2=CC=CC=C2C2C=CC=CC1=2)OC(=O)N[C@H](C(=O)OC1C(F)=C(F)C(F)=C(F)C=1F)CC1C=CC(OC(C)(C)C)=CC=1

Computed Properties

  • Exact Mass: 625.18876380g/mol
  • Monoisotopic Mass: 625.18876380g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 45
  • Rotatable Bond Count: 12
  • Complexity: 968
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 8
  • Topological Polar Surface Area: 73.9?2

Experimental Properties

  • Color/Form: No data avaiable
  • Density: 1.334±0.06 g/cm3 (20 oC 760 Torr),
  • Melting Point: 61-64 oC
  • Boiling Point: 713.3 °C at 760 mmHg
  • Flash Point: 713.3 °C at 760 mmHg
  • Refractive Index: 1.568
  • Solubility: Insuluble (3.1E-8 g/L) (25 oC),
  • Vapor Pressure: 0.0±2.3 mmHg at 25°C

Fmoc-Tyr(tBu)-OPfp Security Information

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Fmoc-Tyr(tBu)-OPfp Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Solvents: Dichloromethane ;  overnight, 0 °C
Reference
β-Gal Gene Expression MRI Reporter in Melanoma Tumor Cells. Design, Synthesis, and in Vitro and in Vivo Testing of a Gd(III) Containing Probe Forming a High Relaxivity, Melanin-Like Structure upon β-Gal Enzymatic Activation
Arena, Francesca; Singh, Jebasingh Bhagavath; Gianolio, Eliana; Stefania, Rachele; Aime, Silvio, Bioconjugate Chemistry, 2011, 22(12), 2625-2635

Production Method 2

Reaction Conditions
Reference
Preparation of pentafluorophenyl esters of Fmoc protected amino acids with pentafluorophenyl trifluoroacetate
Green, Michael; Berman, Judd, Tetrahedron Letters, 1990, 31(41), 5851-2

Production Method 3

Reaction Conditions
1.1 Reagents: Sodium bicarbonate Solvents: Dichloromethane ,  Water
Reference
Synthesis of pentafluorophenyl, 2,4,5-trichlorophenyl and pentachlorophenyl esters of Fmoc-amino acids using Fmoc-amino acid chlorides as intermediates
Babu, Vommina V. Suresh; Ananda, Kuppanna; Mathad, Raveendra I., Letters in Peptide Science, 2001, 7(4), 239-242

Fmoc-Tyr(tBu)-OPfp Raw materials

Fmoc-Tyr(tBu)-OPfp Preparation Products

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