Cas no 860296-24-8 (6-Chloro-5-fluoropicolinic acid)

6-Chloro-5-fluoropicolinic acid is a halogenated picolinic acid derivative with applications in pharmaceutical and agrochemical synthesis. Its structure, featuring both chloro and fluoro substituents on the pyridine ring, enhances reactivity and selectivity in cross-coupling reactions, making it a valuable intermediate for constructing complex heterocyclic compounds. The electron-withdrawing effects of the substituents improve its utility in nucleophilic substitution and metal-catalyzed transformations. This compound is particularly useful in the development of active ingredients for crop protection and medicinal chemistry due to its stability and functional group compatibility. High purity grades are available to meet stringent research and industrial requirements.
6-Chloro-5-fluoropicolinic acid structure
860296-24-8 structure
Product Name:6-Chloro-5-fluoropicolinic acid
CAS No:860296-24-8
MF:C6H3ClFNO2
MW:175.544924020767
MDL:MFCD13185819
CID:1026701
PubChem ID:11412672
Update Time:2025-06-08

6-Chloro-5-fluoropicolinic acid Chemical and Physical Properties

Names and Identifiers

    • 6-Chloro-5-fluoropicolinic acid
    • 2-Chloro-3-fluoropyridine-6-carboxylic acid
    • 6-CHLORO-5-FLUOROPYRIDINE-2-CARBOXYLIC ACID
    • C6H3ClFNO2
    • 2-chloro-3-fluoropyridine-6-carboxylicacid
    • 6-chloro-5-fluoro-pyridine-2-carboxylic Acid
    • JHFKXHUKNYFWJM-UHFFFAOYSA-N
    • 3423AC
    • STL555022
    • BBL101226
    • 2-Chloro-3-fluoro-6-carboxypyridine
    • AM62411
    • TRA0065877
    • AS04721
    • AB66795
    • SY038170
    • 6-Chloro-5-fluoro-2-pyridinecarboxylic acid (ACI)
    • 6-chloro-5-fluoro-2-pyridinecarboxylic acid
    • DB-359473
    • AU-004/43508172
    • DS-14300
    • Z1250208606
    • MFCD13185819
    • 6-Chloro-5-fluoropicolinicacid
    • 6-Chloro-5-fluoropyridine-2-carboxylic acid, AldrichCPR
    • EN300-84298
    • CS-W007835
    • SCHEMBL2595331
    • DTXSID10465020
    • AKOS005257857
    • 6-Chloro-5-fluoro-pyridine-2-carboxylic acid;6-Chloro-5-fluoropicolinic acid
    • 860296-24-8
    • MDL： MFCD13185819
    • Inchi： 1S/C6H3ClFNO2/c7-5-3(8)1-2-4(9-5)6(10)11/h1-2H,(H,10,11)
    • InChI Key： JHFKXHUKNYFWJM-UHFFFAOYSA-N
    • SMILES： O=C(C1C=CC(F)=C(Cl)N=1)O

Computed Properties

  • Exact Mass: 174.98400
  • Monoisotopic Mass: 174.9836342g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 1
  • Complexity: 167
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 50.2
  • XLogP3: 1.8

Experimental Properties

  • Water Partition Coefficient: Slightly soluble in water.
  • PSA: 50.19000
  • LogP: 1.57230

6-Chloro-5-fluoropicolinic acid Security Information

6-Chloro-5-fluoropicolinic acid Customs Data

  • HS CODE：2933399090
  • Customs Data：

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6-Chloro-5-fluoropicolinic acid Pricemore >>

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6-Chloro-5-fluoropicolinic acid Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Phosphorus oxychloride Solvents: Dimethylformamide ;  15 - 30 °C; 1 h, 15 - 30 °C
Reference
Synthesis of 6-(2,6-difluorophenyl)-5-fluoropicolinic acid
Cheng, Chao; Wu, Ping-ping; Shentu, Bao-qing, Gaoxiao Huaxue Gongcheng Xuebao, 2021, 35(2), 324-330

Production Method 2

Reaction Conditions
1.1 Reagents: Tetrabutylammonium fluoride Solvents: Diethyl ether ;  20 h, 25 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  30 min, rt
Reference
Converting core compounds into building blocks: The concept of regiochemically exhaustive functionalization
Marzi, Elena; Bobbio, Carla; Cottet, Fabrice; Schlosser, Manfred, European Journal of Organic Chemistry, 2005, (10), 2116-2123

6-Chloro-5-fluoropicolinic acid Raw materials

6-Chloro-5-fluoropicolinic acid Preparation Products

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