Cas no 86-47-5 (7-Chloro-4-hydroxyquinoline-3-carboxylic acid)

7-Chloro-4-hydroxyquinoline-3-carboxylic acid structure
86-47-5 structure
Product Name:7-Chloro-4-hydroxyquinoline-3-carboxylic acid
CAS No:86-47-5
MF:C10H6ClNO3
MW:223.612541675568
MDL:MFCD08235113
CID:724918
PubChem ID:66579
Update Time:2024-10-26

7-Chloro-4-hydroxyquinoline-3-carboxylic acid Chemical and Physical Properties

Names and Identifiers

    • 7-Chloro-4-hydroxyquinoline-3-carboxylic acid
    • 3-Quinolinecarboxylicacid, 7-chloro-4-hydroxy-
    • 4-Hydroxy-7-chloroquinoline-3-caroboxylic acid
    • 7-Chloro-4-hydroxy-3-quinolinecarboxylic acid
    • 3-carboxy-4-hydroxy-7-chloroquinoline
    • 3-carboxy-4-hydroxy-7-chloro-quinoline
    • NSC 27801
    • NSC 56803
    • 7-Chloro-4-hydroxy-3-quinolinecarboxylic acid (ACI)
    • 4-Hydroxy-7-chloro-3-quinolinecarboxylic acid
    • MDL： MFCD08235113
    • Inchi： 1S/C10H6ClNO3/c11-5-1-2-6-8(3-5)12-4-7(9(6)13)10(14)15/h1-4H,(H,12,13)(H,14,15)
    • InChI Key： SACLIBNEKWTDEG-UHFFFAOYSA-N
    • SMILES： O=C(C1C(O)=C2C(C=C(C=C2)Cl)=NC=1)O

Computed Properties

  • Exact Mass: 223.00400
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 15
  • Rotatable Bond Count: 1
  • Complexity: 340
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 4
  • XLogP3: 2.5

Experimental Properties

  • Color/Form: White needle crystal
  • Density: 1.600
  • Melting Point: 270-272 oC
  • PSA: 70.42000
  • LogP: 2.29200
  • Solubility: Slightly soluble in water, soluble in ethanol, insoluble in petroleum ether

7-Chloro-4-hydroxyquinoline-3-carboxylic acid Security Information

  • WGK Germany：3
  • Hazard Category Code： 36/37/38
  • Safety Instruction： S26-S36
  • RTECS：VB1950000
  • Hazardous Material Identification： Xi
  • Risk Phrases：R36/37/38

7-Chloro-4-hydroxyquinoline-3-carboxylic acid Customs Data

  • HS CODE：2933499090
  • Customs Data：

    China Customs Code:

    2933499090

    Overview:

    2933499090. Other compounds containing quinoline or isoquinoline ring system [but not further fused]. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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7-Chloro-4-hydroxyquinoline-3-carboxylic acid Production Method

Production Method 1

Reaction Conditions
1.1 3 h, 100 °C; 100 °C → rt
1.2 Solvents: Diphenyl ether ;  rt; 2 h, 250 °C; 250 °C → rt
1.3 Reagents: Potassium hydroxide Solvents: Water ;  reflux; reflux → rt
1.4 Reagents: Hydrochloric acid Solvents: Water ;  pH 2, rt
Reference
Dichloro-4-quinolinol-3-carboxylic acid: Synthesis and antioxidant abilities to scavenge radicals and to protect methyl linoleate and DNA
Li, Guo-Xiang; et al, European Journal of Medicinal Chemistry, 2010, 45(5), 1821-1827

Production Method 2

Reaction Conditions
1.1 Reagents: Boron trifluoride etherate
2.1 -
2.2 Reagents: Hydrochloric acid Solvents: Water
Reference
Preparation of 7-chloro-4-hydroxy-3-quinolinecarboxylic acid.
, China, , ,

Production Method 3

Reaction Conditions
1.1 -
1.2 Reagents: Hydrochloric acid Solvents: Water
Reference
Preparation of 7-chloro-4-hydroxy-3-quinolinecarboxylic acid.
, China, , ,

Production Method 4

Reaction Conditions
1.1 Solvents: Methanol
2.1 Reagents: Boron trifluoride etherate
3.1 -
3.2 Reagents: Hydrochloric acid Solvents: Water
Reference
Preparation of 7-chloro-4-hydroxy-3-quinolinecarboxylic acid.
, China, , ,

Production Method 5

Reaction Conditions
1.1 rt; 3 h, 130 °C
2.1 Solvents: Diphenyl ether ;  2 h, 250 °C
3.1 Reagents: Sodium hydroxide Solvents: Water ;  2 h, reflux
3.2 Reagents: Acetic acid ;  pH 2 - 3
Reference
Design, synthesis, and biological evaluation of novel quinoline derivatives as HIV-1 Tat-TAR interaction inhibitors
Chen, Shuguang; et al, Bioorganic & Medicinal Chemistry, 2009, 17(5), 1948-1956

7-Chloro-4-hydroxyquinoline-3-carboxylic acid Raw materials

7-Chloro-4-hydroxyquinoline-3-carboxylic acid Preparation Products

7-Chloro-4-hydroxyquinoline-3-carboxylic acid Suppliers

Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:86-47-5)7-CHLORO-4-HYDROXY QUINOLINE-3-CARBOXYLIC ACID
Order Number:sfd350
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:32
Price ($):discuss personally

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Recommended suppliers
Suzhou Senfeida Chemical Co., Ltd
(CAS:86-47-5)7-CHLORO-4-HYDROXY QUINOLINE-3-CARBOXYLIC ACID
sfd350
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
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