Production Method 1

50-84-0

86-38-4

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Copper Solvents: Dimethylformamide ;  4 h, 130 °C
2.1 Reagents: Phosphorus oxychloride ;  2 h, 105 °C

Reference

Design, synthesis and biological evaluation of novel phthalazinone acridine derivatives as dual PARP and Topo inhibitors for potential anticancer agents

Dai, Qiuzi; et al, Chinese Chemical Letters, 2020, 31(2), 404-408

Production Method 2

86-38-4

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  3 h, 130 °C

Reference

Novel synthetic 9-benzyloxyacridine analogue as both tyrosine kinase and topoisomerase I inhibitor

Lang, Xu-Liang; et al, Chinese Chemical Letters, 2013, 24(8), 677-680

Production Method 3

91-38-3

86-38-4

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  3 h, 130 °C

Reference

Exploration of acridine scaffold as a potentially interesting scaffold for discovering novel multi-target VEGFR-2 and Src kinase inhibitors

Luan, Xudong; et al, Bioorganic & Medicinal Chemistry, 2011, 19(11), 3312-3319

Production Method 4

50-84-0

86-38-4

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: Copper Solvents: Dimethylformamide ;  overnight, 130 °C
1.2 Reagents: Phosphorus oxychloride Solvents: Dimethylformamide ;  3 - 5 h, reflux; reflux → rt
1.3 Reagents: Sodium hydroxide Solvents: Water ;  pH 8, cooled

Reference

Design, synthesis and biological research of novel N-phenylbenzamide-4-methylamine acridine derivatives as potential topoisomerase I/II and apoptosis-inducing agents

Zhang, Bin; et al, Bioorganic & Medicinal Chemistry Letters, 2019, 29(23),

Production Method 5

50-84-0

86-38-4

Reaction Conditions

1.1 Reagents: Pyridine ,  Potassium carbonate Catalysts: Copper Solvents: 1-Pentanol ;  overnight, 130 °C; 130 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  < pH 5, rt
2.1 Reagents: Phosphorus oxychloride ;  5 h, 120 °C

Reference

A scalable process for the synthesis of key intermediates novoldiamine & hydroxynovaldiamine and their utility in chloroquine, hydroxychloroquine and mepacrine synthesis

Chouhan, N. K.; et al, Synthetic Communications, 2022, 52(7), 1004-1011

Production Method 6

212892-02-9

86-38-4

Reaction Conditions

1.1 Reagents: BINAP Catalysts: Palladium diacetate
1.2 Reagents: Barium hydroxide, octahydrate Solvents: Methanol ;  rt → 80 °C; 2 h, 80 °C
1.3 Reagents: Phosphorus oxychloride

Reference

A convenient procedure for parallel ester hydrolysis

Anderson, Marc O.; et al, Synlett, 2004, (13), 2391-2393

Production Method 7

2735-04-8

2516-96-3

86-38-4

Reaction Conditions

1.1 Reagents: Pyridine ,  Potassium carbonate Catalysts: Bronze Solvents: 1-Pentanol ;  5 h, reflux; reflux → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  < pH 7, rt
2.1 Solvents: Phosphorus oxychloride ;  6 h, reflux; reflux → rt
2.2 Reagents: Ammonia Solvents: Chloroform ,  Water ;  pH 8

Reference

Convenient access to substituted acridines by a Buchwald-Hartwig amination

Csuk, Rene; et al, Tetrahedron, 2004, 60(27), 5737-5750

6,9-dichloro-2-methoxy-acridine Raw materials

• 2,4-Dimethoxyaniline
• 4-Chloro-2-((4-methoxyphenyl)amino)benzoic acid
• 2-Chloro-5-nitrobenzoic acid
• 2,4-Dichlorobenzoic acid
• Benzoic acid, 4-chloro-2-[[(trifluoromethyl)sulfonyl]oxy]-, methyl ester

6,9-dichloro-2-methoxy-acridine Preparation Products

• 6,9-dichloro-2-methoxy-acridine (86-38-4)

• 1. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 2. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 3. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
  Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
• 4. Emerging investigator series: kinetics of diopside reactivity for carbon mineralization in mafic–ultramafic rocks
  BrianaAguila,LandonHardee,H.ToddSchaef,SiavashZare,MohammadJavadAbdolhosseiniQomi,JarrodV.Crum,JadeE.HollimanJr.,ElenaTajueloRodriguez,LawrenceM.Anovitz,KevinM.Rosso,QuinR.S.Miller
• 5. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Acridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Benzoquinolines Acridines

• 4295-04-9(4-Chloro-6-methoxyquinoline)
• 16492-13-0(9-Chloro-2-methoxyacridine)
• 88914-97-0(&nbsp;)
• 205448-31-3(4-Chloro-6-methoxyquinolin-7-ol)
• 68500-37-8(4-Chloro-7-methoxyquinoline)
• 103862-63-1(4-Chloro-6-ethoxyquinoline)
• 35654-56-9(4-Chloro-6,7-dimethoxyquinoline)
• 16778-21-5(4-Chloro-8-methoxyquinoline)
• 26707-52-8(7-chloro-4-methoxyquinoline)
• 89784-84-9(Acridine, 9-chloro-4,5-dimethoxy-)