Production Method 1

877624-37-8

858124-35-3

Reaction Conditions

1.1 Reagents: Silver nitrate Solvents: Methanol ,  Water ;  reflux

Reference

An improved synthesis of (-)-martinellic acid via radical addition-cyclization-elimination reaction of chiral oxime ether

Miyata, Okiko; et al, Synlett, 2006, (6), 893-896

Production Method 2

254746-40-2

858124-35-3

Reaction Conditions

1.1 Reagents: 2-Iodoxybenzoic acid Solvents: Ethyl acetate ;  rt → 80 °C; 2 h, 80 °C

Reference

Stereoselective synthesis of a Podophyllum lignan core by intramolecular reductive nickel-catalysis

Xiao, Jian; et al, Chemical Communications (Cambridge, 2018, 54(16), 2040-2043

Production Method 3

148547-19-7

858124-35-3

Reaction Conditions

1.1 Solvents: Acetic acid ;  30 min, 0 °C; 1 h, > 0 °C
2.1 Reagents: Sulfuric acid Solvents: Methanol ,  Water ;  30 min, reflux
2.2 Reagents: Hydrochloric acid Solvents: Tetrahydrofuran ,  Water ;  reflux

Reference

Hydrogen sulfide induced supramolecular self-assembly in living cells

Wei, Simin; et al, Chemical Communications (Cambridge, 2018, 54(65), 9051-9054

Production Method 4

1621912-33-1

858124-35-3

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Methanol ;  0 °C → rt; 10 min, rt; 3 h, reflux
2.1 Reagents: Diisobutylaluminum hydride Solvents: Tetrahydrofuran ,  Hexane ;  -78 °C; -78 °C → rt; 6 h, rt
2.2 Solvents: Water ;  0 °C
2.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1
3.1 Reagents: 2-Iodoxybenzoic acid Solvents: Ethyl acetate ;  rt → 80 °C; 2 h, 80 °C

Reference

Stereoselective synthesis of a Podophyllum lignan core by intramolecular reductive nickel-catalysis

Xiao, Jian; et al, Chemical Communications (Cambridge, 2018, 54(16), 2040-2043

Production Method 5

7697-28-1

858124-35-3

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Methanol ;  overnight, reflux
2.1 Solvents: Acetic acid ;  30 min, 0 °C; 1 h, > 0 °C
3.1 Reagents: Sulfuric acid Solvents: Methanol ,  Water ;  30 min, reflux
3.2 Reagents: Hydrochloric acid Solvents: Tetrahydrofuran ,  Water ;  reflux

Reference

Hydrogen sulfide induced supramolecular self-assembly in living cells

Wei, Simin; et al, Chemical Communications (Cambridge, 2018, 54(65), 9051-9054

Production Method 6

7697-28-1

858124-35-3

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Methanol ;  overnight, reflux
2.1 Reagents: Chromium trioxide ,  Sulfuric acid Solvents: Acetic acid ,  Acetic anhydride ;  30 min, cooled; 1 h
3.1 Catalysts: Sulfuric acid Solvents: Methanol ,  Water ;  30 min, reflux
3.2 Reagents: Hydrochloric acid Solvents: Tetrahydrofuran ,  Water ;  reflux

Reference

Post-synthetic modification of tagged metal-organic frameworks

Burrows, Andrew D.; et al, Angewandte Chemie, 2008, 47(44), 8482-8486

Production Method 7

1095432-84-0

858124-35-3

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Methanol ,  Water ;  30 min, reflux
1.2 Reagents: Hydrochloric acid Solvents: Tetrahydrofuran ,  Water ;  reflux

Reference

Post-synthetic modification of tagged metal-organic frameworks

Burrows, Andrew D.; et al, Angewandte Chemie, 2008, 47(44), 8482-8486

Production Method 8

1095432-84-0

858124-35-3

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Methanol ,  Water ;  1 h, reflux

Reference

Inter- and intramolecular hydroacylation of alkenes employing a bifunctional catalyst system

Vautravers, Nicolas R.; et al, Chemical Communications (Cambridge, 2011, 47(23), 6635-6637

Production Method 9

52178-50-4

858124-35-3

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide ,  Trifluoromethanesulfonic acid Catalysts: 2-Amino-4-nitrobenzoic acid ,  Silver trifluoroacetate ,  Palladium diacetate Solvents: 1,2-Dichloroethane ;  24 h, 90 °C

Reference

Diverse ortho-C(sp2)-H Functionalization of Benzaldehydes Using Transient Directing Groups

Liu, Xi-Hai; et al, Journal of the American Chemical Society, 2017, 139(2), 888-896

Production Method 10

148547-19-7

858124-35-3

Reaction Conditions

1.1 Reagents: Acetic acid ,  Acetic anhydride ,  Sulfuric acid Solvents: Water ;  5 min, 0 °C
1.2 Reagents: Chromium trioxide ;  30 min; 4 h, 0 °C
1.3 Solvents: Water ;  1 h, 0 °C
1.4 Reagents: Sulfuric acid Solvents: Methanol ,  Water ;  1 h, 85 °C
1.5 Reagents: Hydrochloric acid Solvents: Tetrahydrofuran ,  Water ;  3 h, 80 °C

Reference

Three-Component Dynamic Covalent Chemistry: From Janus Small Molecules to Functional Polymers

Liu, Hongxu ; et al, Journal of the American Chemical Society, 2021, 143(49), 20735-20746

Production Method 11

148547-19-7

858124-35-3

Reaction Conditions

1.1 Reagents: Chromium trioxide ,  Sulfuric acid Solvents: Acetic acid ;  30 min, cooled; 1 h, cooled; 40 min, cooled
2.1 Reagents: Sulfuric acid Solvents: Methanol ,  Water ;  1 h, reflux

Reference

Inter- and intramolecular hydroacylation of alkenes employing a bifunctional catalyst system

Vautravers, Nicolas R.; et al, Chemical Communications (Cambridge, 2011, 47(23), 6635-6637

Production Method 12

148547-19-7

858124-35-3

Reaction Conditions

1.1 Reagents: Chromium trioxide ,  Sulfuric acid Solvents: Water ;  1 h, 0 °C
2.1 Catalysts: Sulfuric acid Solvents: Methanol ,  Water ;  30 min, reflux

Reference

Mimic of the Green Fluorescent Protein β-Barrel: Photophysics and Dynamics of Confined Chromophores Defined by a Rigid Porous Scaffold

Williams, Derek E.; et al, Journal of the American Chemical Society, 2015, 137(6), 2223-2226

Production Method 13

28730-78-1

858124-35-3

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Tetrahydrofuran ,  Hexane ;  -78 °C; -78 °C → rt; 6 h, rt
1.2 Solvents: Water ;  0 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1
2.1 Reagents: 2-Iodoxybenzoic acid Solvents: Ethyl acetate ;  rt → 80 °C; 2 h, 80 °C

Reference

Stereoselective synthesis of a Podophyllum lignan core by intramolecular reductive nickel-catalysis

Xiao, Jian; et al, Chemical Communications (Cambridge, 2018, 54(16), 2040-2043

methyl 4-bromo-3-formyl-benzoate Raw materials

• methyl 4-bromo-3-(hydroxymethyl)benzoate
• Methyl 4-bromo-3-methylbenzoate
• 2-Bromo-5-(methoxycarbonyl)benzoic acid
• Methyl 3-formylbenzoate
• 4-Bromo-3-methylbenzoic acid
• Benzoic acid, 4-bromo-3-(dibromomethyl)-, methyl ester
• (2-Bromo-5-(methoxycarbonyl)phenyl)methylene diacetate
• Dimethyl 4-Bromoisophthalate

methyl 4-bromo-3-formyl-benzoate Preparation Products

• methyl 4-bromo-3-formyl-benzoate (858124-35-3)

• 1. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acid esters

• 610-94-6(Methyl 2-bromobenzoate)
• 131001-86-0(Methyl 2-bromo-3-methylbenzoate)
• 18643-86-2(1,4-dimethyl 2-bromobenzene-1,4-dicarboxylate)
• 245549-92-2(Benzoic acid,2,5-dibromo-4-methyl-, methyl ester)
• 148547-19-7(Methyl 4-bromo-3-methylbenzoate)
• 18014-00-1(Dimethyl 2,5-dibromoterephthalate)
• 87808-49-9(Methyl 2-bromo-4-methylbenzoate)
• 90971-88-3(Methyl 2-bromo-5-methylbenzoate)
• 90766-77-1(1,3-Benzenedicarboxylic acid, 4,6-dibromo-, dimethyl ester)
• 57381-43-8(Methyl 2,5-dibromobenzoate)