Production Method 1

122773-97-1

85386-14-7

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Ethanol

Reference

Synthesis of 2,5'-bipyrimidines from substituted 5-cyanopyrimidines

Mamaev, V. P.; et al, Khimiya Geterotsiklicheskikh Soedinenii, 1988, (3), 371-5

Production Method 2

1670-14-0

80370-42-9

85386-14-7

Reaction Conditions

1.1 Reagents: Sodium ethoxide Solvents: Ethanol

Reference

Reaction of 2-dimethylaminomethylene-1,3-diones with dinucleophiles. VIII. Synthesis of ethyl and methyl 2,4-disubstituted 5-pyrimidinecarboxylates

Schenone, Pietro; et al, Journal of Heterocyclic Chemistry, 1990, 27(2), 295-305

Production Method 3

24755-82-6

85386-14-7

Reaction Conditions

1.1 Reagents: Zinc Solvents: Tetrahydrofuran ;  1 h, 60 °C
1.2 Reagents: Acetic acid ;  23 h, 60 °C

Reference

Characterization of amide bond conformers for a novel heterocyclic template of N-acylhydrazone derivatives

Basilio Lopes, Alexandra; et al, Molecules, 2013, 18(10), 11683-11704

Production Method 4

6148-64-7

85386-14-7

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride Solvents: Dimethylformamide
2.1 Reagents: Sodium Solvents: Ethanol ;  1 h, reflux

Reference

Inhibitors of NF-κB and AP-1 Gene Expression: SAR Studies on the Pyrimidine Portion of 2-Chloro-4-trifluoromethylpyrimidine-5-[N-(3',5'-bis(trifluoromethyl)phenyl)carboxamide]

Palanki, Moorthy S. S.; et al, Journal of Medicinal Chemistry, 2000, 43(21), 3995-4004

Production Method 5

77232-48-5

85386-14-7

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Water
2.1 Reagents: Hydrochloric acid Solvents: Ethanol

Reference

Synthesis of 2,5'-bipyrimidines from substituted 5-cyanopyrimidines

Mamaev, V. P.; et al, Khimiya Geterotsiklicheskikh Soedinenii, 1988, (3), 371-5

Production Method 6

122774-00-9

85386-14-7

Reaction Conditions

1.1 Reagents: Sodium methoxide Solvents: Methanol
2.1 Solvents: Phosphorus oxychloride
3.1 Reagents: Hydrochloric acid Solvents: Ethanol

Reference

Synthesis of 2,5'-bipyrimidines from substituted 5-cyanopyrimidines

Mamaev, V. P.; et al, Khimiya Geterotsiklicheskikh Soedinenii, 1988, (3), 371-5

Production Method 7

85386-15-8

85386-14-7

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Ethanol

Reference

Synthesis of 2,5'-bipyrimidines from substituted 5-cyanopyrimidines

Mamaev, V. P.; et al, Khimiya Geterotsiklicheskikh Soedinenii, 1988, (3), 371-5

Production Method 8

92385-43-8

1670-14-0

85386-14-7

Reaction Conditions

1.1 Reagents: Sodium Solvents: Ethanol ;  1 h, reflux

Reference

Inhibitors of NF-κB and AP-1 Gene Expression: SAR Studies on the Pyrimidine Portion of 2-Chloro-4-trifluoromethylpyrimidine-5-[N-(3',5'-bis(trifluoromethyl)phenyl)carboxamide]

Palanki, Moorthy S. S.; et al, Journal of Medicinal Chemistry, 2000, 43(21), 3995-4004

Production Method 9

55613-22-4

85386-14-7

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  1 h, 100 °C
1.2 Reagents: Zinc Solvents: Tetrahydrofuran ;  1 h, 60 °C
1.3 Reagents: Acetic acid ;  23 h, 60 °C

Reference

Characterization of amide bond conformers for a novel heterocyclic template of N-acylhydrazone derivatives

Basilio Lopes, Alexandra; et al, Molecules, 2013, 18(10), 11683-11704

Production Method 10

1670-14-0

80370-42-9

85386-14-7

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  rt; 4 h, 100 °C

Reference

Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents

Zhao, Shizhen; et al, European Journal of Medicinal Chemistry, 2017, 137, 96-107

Production Method 11

1670-14-0

80370-42-9

85386-14-7

Reaction Conditions

Reference

Product class 12: pyrimidines

von Angerer, S., Science of Synthesis, 2004, 16, 379-572

Production Method 12

623-47-2

85386-14-7

Reaction Conditions

Reference

Product class 12: pyrimidines

von Angerer, S., Science of Synthesis, 2004, 16, 379-572

Production Method 13

109-94-4

262293-82-3

85386-14-7

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  < 0 °C; 24 h, rt
1.2 Solvents: Water ;  rt
2.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  rt; 4 h, 100 °C

Reference

Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents

Zhao, Shizhen; et al, European Journal of Medicinal Chemistry, 2017, 137, 96-107

Production Method 14

122773-96-0

85386-14-7

Reaction Conditions

1.1 Solvents: Phosphorus oxychloride
2.1 Reagents: Hydrochloric acid Solvents: Ethanol

Reference

Synthesis of 2,5'-bipyrimidines from substituted 5-cyanopyrimidines

Mamaev, V. P.; et al, Khimiya Geterotsiklicheskikh Soedinenii, 1988, (3), 371-5

Production Method 15

87-13-8

1670-14-0

85386-14-7

Reaction Conditions

1.1 Reagents: Sodium Solvents: Ethanol ;  9 h, rt
2.1 Reagents: Phosphorus oxychloride ;  1 h, 100 °C
2.2 Reagents: Zinc Solvents: Tetrahydrofuran ;  1 h, 60 °C
2.3 Reagents: Acetic acid ;  23 h, 60 °C

Reference

Characterization of amide bond conformers for a novel heterocyclic template of N-acylhydrazone derivatives

Basilio Lopes, Alexandra; et al, Molecules, 2013, 18(10), 11683-11704

Ethyl 2-phenylpyrimidine-5-carboxylate Raw materials

• Ethyl formate
• 1,3-diethyl 2-(ethoxymethylidene)propanedioate
• Ethyl potassium malonate
• 2-phenylpyrimidine-5-carbonitrile
• ethyl 4-chloro-2-phenylpyrimidine-5-carboxylate
• 5-Pyrimidinecarbonylchloride, 2-phenyl-
• 5-methyl-2-phenylpyrimidine
• Ethyl 3-dimethylamino-2-formylacrylate
• ethyl propiolate
• benzenecarboximidamide hydrochloride
• 2-Phenyl-5-pyrimidinecarboxamide
• Ethyl 2-formyl-3-oxopropanoate
• ethyl 4-hydroxy-2-phenylpyrimidine-5-carboxylate
• 2-Phenylpyrimidine-5-carboxylic acid
• ETHYL 3,3-DIMETHOXYPROPANOATE

Ethyl 2-phenylpyrimidine-5-carboxylate Preparation Products

• Ethyl 2-phenylpyrimidine-5-carboxylate (85386-14-7)

• 1. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Fc microparticles can modulate the physical extent and magnitude of complement activity?
  David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474
• 3. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 4. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 5. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Pyrimidinecarboxylic acids and derivatives

• 1092568-82-5(Methyl 3-(5-methylpyrimidin-2-yl)benzoate)
• 65586-74-5(5-Pyrimidinecarboxylic acid, 2-(4-methylphenyl)- (9CI))
• 64074-29-9(methyl 2-phenylpyrimidine-5-carboxylate)
• 1237518-65-8(Methyl 5-(pyrimidin-2-yl)nicotinate)
• 933988-19-3(Methyl 2-(pyridin-3-yl)pyrimidine-5-carboxylate)
• 259807-46-0(Ethyl 2-(pyridin-4-YL)pyrimidine-5-carboxylate)
• 928713-04-6(2-(M-Tolyl)pyrimidine-5-carboxylic acid)
• 304693-58-1(ethyl 2-(4-chlorophenyl)pyrimidine-5-carboxylate)
• 122773-97-1(2-Phenylpyrimidine-5-carboxylic acid)
• 65586-64-3(Ethyl 2-(4-methylphenyl)pyrimidine-5-carboxylate)