Production Method 1

3788-94-1

85290-78-4

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ;  rt → 5 °C; 0 - 5 °C; 5 °C → rt; 0.5 h, rt

Reference

Synthesis of 3-methyl-1H-pyrazole-4-carboxylic acid and 3,5-dimethyl-1H-pyrazole-4-carboxylic acid

Chen, Juan; Xi, Haitao; Zhang, Xiuqin; Meng, Qi; Jiang, Yan; et al, Jingxi Huagong, 2007, 24(2), 199-201

Production Method 2

3788-94-1

85290-78-4

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ;  cooled; rt

Reference

Synthesis and antifungal activity of the derivatives of novel pyrazole carboxamide and isoxazolol pyrazole carboxylate

Sun, Jialong; Zhou, Yuanming, Molecules, 2015, 20(3), 4383-4394

Production Method 3

57905-32-5

85290-78-4

Reaction Conditions

1.1 Reagents: Hydrazine Solvents: Ethanol ;  24 h, rt

Reference

New reactivity of nitropyrimidinone: ring transformation and N-C transfer reactions

Nishiwaki, Nagatoshi; Matsushima, Kazuo; Chatani, Miki; Tamura, Mina; Ariga, Masahiro, Synlett, 2004, (4), 703-707

Production Method 4

3724-43-4

75519-47-0

85290-78-4

Reaction Conditions

1.1 Solvents: Dichloromethane ;  15 min, 0 °C; 50 °C; 5 min, rt

Reference

An efficient synthesis of 1-H-pyrazole-4-carboxylic acid esters with Vilsmeier reagent under neat conditions

Sridhar, R.; Sivaprasad, G.; Perumal, P. T., Journal of Heterocyclic Chemistry, 2004, 41(3), 405-408

Production Method 5

40704-11-8

85290-78-4

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Ethanol ;  20 h, 85 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 6 - 7

Reference

Discovery of a Novel Series of Orally Active Nociceptin/Orphanin FQ (NOP) Receptor Antagonists Based on a Dihydrospiro(piperidine-4,7'-thieno[2,3-c]pyran) Scaffold

Toledo, Miguel A.; Pedregal, Concepcion; Lafuente, Celia; Diaz, Nuria; Martinez-Grau, Maria Angeles; et al, Journal of Medicinal Chemistry, 2014, 57(8), 3418-3429

Ethyl 3-methyl-1H-pyrazole-4-carboxylate Raw materials

• (Chloromethylene)dimethylammonium Chloride
• 3-Methyl-1H-pyrazole-4-carboxylic acid
• Butanoic acid, 2-(aminomethylene)-3-oxo-, ethyl ester
• Butanoic acid, 3-hydrazono-, ethyl ester
• ethyl 2-(ethoxymethylene)-3-oxo-butanoate

Ethyl 3-methyl-1H-pyrazole-4-carboxylate Preparation Products

• Ethyl 3-methyl-1H-pyrazole-4-carboxylate (85290-78-4)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazole carboxylic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles Pyrazole carboxylic acids and derivatives

• 23170-45-8(methyl 5-methyl-1H-pyrazole-4-carboxylate)
• 119741-57-0(ethyl 3-cyano-1H-pyrazole-4-carboxylate)
• 40704-11-8(3-Methyl-1H-pyrazole-4-carboxylic acid)
• 137487-60-6(1H-Pyrazole-4-carboxylicacid, 3-(chloromethyl)-, ethyl ester)
• 73981-23-4(Ethyl 3-ethyl-1H-pyrazole-4-carboxylate)
• 33090-69-6(Methyl 3-cyano-1H-pyrazole-4-carboxylate)
• 35691-93-1(Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate)
• 25016-18-6(Methyl 3,5-dimethyl-1H-pyrazole-4-carboxylate)
• 342026-17-9(ethyl 3-(propan-2-yl)-1H-pyrazole-4-carboxylate)
• 123374-28-7(Ethyl 5-Propyl-1H-pyrazole-4-carboxylate)