Production Method 1

51145-57-4

85290-76-2

85290-77-3

Reaction Conditions

1.1 Solvents: Methanol

Reference

Reaction of 2-dimethylaminomethylene-1,3-diones with dinucleophiles. VI. Synthesis of ethyl or methyl 1,5-disubstituted 1H-pyrazole-4-carboxylates

Menozzi, Giulia; Mosti, Luisa; Schenone, Pietro, Journal of Heterocyclic Chemistry, 1987, 24(6), 1669-75

Production Method 2

85290-78-4

85290-76-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  8 h, rt

Reference

Comprehensive evaluation of chiral penflufen metabolite (penflufen-3-hydroxy-butyl): Identification, synthesis, enantioseparation, toxicity and enantioselective metabolism

Di, Shanshan; Liu, Ruiquan; Liu, Zhenzhen; Xu, Hao; Zhao, Huiyu; et al, Ecotoxicology and Environmental Safety, 2023, 251,

Production Method 3

141-97-9

4637-24-5

85290-76-2

85290-77-3

Reaction Conditions

1.1 Solvents: 2,2,2-Trifluoroethanol ;  0 °C; 10 min, rt

Reference

Catalyst-free one-pot synthesis of 1,4,5-trisubstituted pyrazoles in 2,2,2-trifluoroethanol

Alinezhad, Heshmatollah; Tajbakhsh, Mahmood; Zare, Mahboobeh, Journal of Fluorine Chemistry, 2011, 132(11), 995-1000

Production Method 4

66975-53-9

49836-24-0

85290-76-2

85290-77-3

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  1 - 10 h, -20 °C

Reference

Toward Continuous-Flow Synthesis of Biologically Interesting Pyrazole Derivatives

Das, Amrita; Ishitani, Haruro; Kobayashi, Shu, Advanced Synthesis & Catalysis, 2019, 361(22), 5127-5132

Production Method 5

3788-94-1

85290-76-2

Reaction Conditions

Reference

Systemic fungicides. The synthesis of certain pyrazole analogs of carboxin

Huppatz, John L., Australian Journal of Chemistry, 1983, 36(1), 135-47

Production Method 6

3788-94-1

85290-76-2

Reaction Conditions

1.1 Solvents: Ethanol ;  rt; 1 h, 5 °C; 3 h, reflux

Reference

Synthesis and Nematocidal Activity of N-Substituted 3-Methyl-1H-pyrazole-4-carboxamide Derivatives Against Meloidogyne incognita

Cheng, Long; Shen, Zhong-Hua; Xu, Tian-Ming; Tan, Cheng-Xia; Weng, Jian-Quan; et al, Journal of Heterocyclic Chemistry, 2018, 55(4), 946-950

Ethyl 1,3-dimethyl-1H-pyrazole-4-carboxylate Raw materials

• Ethyl acetoacetate
• (dimethoxymethyl)dimethylamine
• ethyl 2-(dimethylaminomethylene)-3-oxo-butanoate
• Ethyl 3-methyl-1H-pyrazole-4-carboxylate
• ethyl 2-(ethoxymethylene)-3-oxo-butanoate
• Butanoic acid, 2-(ethoxymethylene)-3-oxo-, ethyl ester, (Z)-
• Ethyl 2-(ethoxymethylene)-3-oxobutanoate

Ethyl 1,3-dimethyl-1H-pyrazole-4-carboxylate Preparation Products

• Ethyl 1,5-dimethyl-1H-pyrazole-4-carboxylate (85290-77-3)
• Ethyl 1,3-dimethyl-1H-pyrazole-4-carboxylate (85290-76-2)

• 1. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 2. An assay for the enzyme N-acetyl-β-d-glucosaminidase (NAGase) based on electrochemical detection using screen-printed carbon electrodes (SPCEs)
  R. M. Pemberton,J. P. Hart,T. T. Mottram Analyst, 2001,126, 1866-1871
• 3. An artificial blood vessel implanted three-dimensional microsystem for modeling transvascular migration of tumor cells?
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• 4. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 5. An approach to the structure and vibrational analysis of cis- and trans-3-chlorostyrene through IR/Raman and INS spectroscopies and theoretical ab initio/DFT calculations?
  J. M. Granadino-Roldán,M. Fernández-Gómez,A. Navarro,T. Pe?a Ruiz,U. A. Jayasooriya Phys. Chem. Chem. Phys., 2004,6, 1133-1143

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazole carboxylic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles Pyrazole carboxylic acids and derivatives

• 141573-95-7(3-Difluoromethyl-1-methylpyrazole-4-carboxylic Acid Ethyl Ester)
• 33090-56-1(3-cyano-1-methyl-1H-Pyrazole-4-carboxylic acid ethyl ester)
• 111493-69-7(1H-Pyrazole-4-carboxylic acid, 3-(methoxymethyl)-1-methyl-, ethyl ester)
• 1176629-22-3(Ethyl 3-(bromomethyl)-1-methyl-1h-pyrazole-4-carboxylate)
• 78703-53-4(1,3-Dimethyl-1H-pyrazole-4-carboxylic acid)
• 10514-60-0(3,4-diethyl 1-methyl-1H-pyrazole-3,4-dicarboxylate)
• 78703-54-5(Methyl 1,5-dimethylpyrazole-4-carboxylate)
• 25016-19-7(methyl 1,3,5-trimethylpyrazole-4-carboxylate)
• 56079-16-4(ETHYL 1,3,5-TRIMETHYL-1H-PYRAZOLE-4-CARBOXYLATE)
• 85290-77-3(Ethyl 1,5-dimethyl-1H-pyrazole-4-carboxylate)