Production Method 1

5370-25-2

852619-28-4

Reaction Conditions

1.1 Catalysts: Sodium bromide Solvents: Dimethyl sulfoxide ;  rt → 85 °C
1.2 Reagents: Sulfuric acid Solvents: Water ;  5 - 7 min, 110 - 115 °C
1.3 Reagents: Water ;  5 min, reflux

Reference

Synthesis and X-ray Characterization of Alkali Metal 2-Acyl-1,1,3,3-tetracyanopropenides

Karpov, Sergey V.; Grigor'ev, Arthur A.; Kayukov, Yakov S.; Karpova, Irina V.; Nasakin, Oleg E.; et al, Journal of Organic Chemistry, 2016, 81(15), 6402-6408

Production Method 2

5370-25-2

852619-28-4

Reaction Conditions

1.1 Reagents: Dimethyl sulfoxide ,  Hydrogen bromide

Reference

The synthesis and ring opening of 3-aroyl(heteroaroyl)-1,2-dicyanocyclopropane-1,2-dicarboxylates

Karpov, Sergey V.; Kayukov, Yakov S.; Grigorev, Arthur A.; Tafeenko, Victor A., Tetrahedron Letters, 2015, 56(13), 1732-1734

Production Method 3

5370-25-2

852619-28-4

21175-51-9

Reaction Conditions

1.1 Reagents: Selenium dioxide ,  Water Solvents: 1,4-Dioxane ;  5 h, 80 °C

Reference

Substrate-Controlled Three-Component Synthesis of Diverse Fused Heterocycles

Peshkov, Anatoly A.; Gapanenok, Diana; Puzyk, Aleksandra; Amire, Niyaz; Novikov, Alexander S. ; et al, Journal of Organic Chemistry, 2023, 88(15), 10508-10524

1-(5-Bromothiophen-2-yl)-2,2-dihydroxyethanone Raw materials

• 1-(5-bromothiophen-2-yl)ethan-1-one

1-(5-Bromothiophen-2-yl)-2,2-dihydroxyethanone Preparation Products

• 2-(5-bromothiophen-2-yl)-2-oxoacetaldehyde hydrate (21175-51-9)
• 1-(5-Bromothiophen-2-yl)-2,2-dihydroxyethanone (852619-28-4)

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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

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