Production Method 1

851386-42-0

851386-43-1

Reaction Conditions

1.1 Reagents: Zinc ,  Ammonia Solvents: Water ;  2 h, 25 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 1, rt

Reference

Selective Functionalization of 2-Fluoropyridine, 2,3-Difluoropyridine, and 2,5-Difluoropyridine at Each Vacant Position

Bobbio, Carla; Schlosser, Manfred, Journal of Organic Chemistry, 2005, 70(8), 3039-3045

Production Method 2

851386-42-0

851386-43-1

Reaction Conditions

Reference

Product subclass 7: organometallic compounds of potassium

Mordini, Alessandro; Valacchi, M., Science of Synthesis, 2006, 8, 1437-1474

2,5-difluoropyridine-3-carboxylic acid Raw materials

• 4-Chloro-2,5-difluoropyridine-3-carboxylic Acid

2,5-difluoropyridine-3-carboxylic acid Preparation Products

• 2,5-difluoropyridine-3-carboxylic acid (851386-43-1)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

• 393-55-5(2-Fluoronicotinic acid)
• 171178-50-0(2,6-difluoropyridine-3-carboxylic acid)
• 773109-19-6(3-Pyridinecarboxylicacid, 2,5,6-trifluoro-)
• 849937-91-3(4,6-difluoropyridine-3-carboxylic acid)
• 675602-92-3(2,3,6-Trifluoroisonicotinic Acid)
• 1227602-25-6(2,5-Difluoronicotinaldehyde)
• 851386-33-9(5,6-difluoropyridine-3-carboxylic acid)
• 851386-31-7(2,3-difluoropyridine-4-carboxylic acid)
• 851386-39-5(2,5-Difluoroisonicotinic acid)
• 885267-35-6(6-fluoro-5-methylpyridine-3-carboxylic acid)