Production Method 1

64248-62-0

85118-04-3

Reaction Conditions

1.1 Reagents: Cesium carbonate ,  1,8-Diazabicyclo[5.4.0]undec-7-ene Catalysts: Cuprous iodide Solvents: Nitromethane ,  Water ;  rt; 1 h, 100 °C

Reference

Nitrile Hydration Reaction Using Copper Iodide/Cesium Carbonate/DBU in Nitromethane-Water

Kuwabara, Jun; Sawada, Yoshiharu; Yoshimatsu, Mitsuhiro, Synlett, 2018, 29(15), 2061-2065

Production Method 2

72235-53-1

85118-04-3

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide ,  Oxygen Catalysts: Carbonylchlorohydrotris(triphenylphosphine)ruthenium Solvents: tert-Butanol ;  12 h, 70 °C

Reference

Highly Selective Ruthenium-Catalyzed Direct Oxygenation of Amines to Amides

Ray, Ritwika; Hazari, Arijit Singha; Chandra, Shubhadeep; Maiti, Debabrata ; Lahiri, Goutam Kumar, Chemistry - A European Journal, 2018, 24(5), 1067-1071

Production Method 3

85118-04-3

Reaction Conditions

1.1 Reagents: Lithium hydroxide Solvents: Water ;  2 h, rt

Reference

Ring Opening/Site Selective Cleavage in N-Acyl Glutarimide to Synthesize Primary Amides

Govindan, Karthick ; Lin, Wei-Yu, Organic Letters, 2021, 23(5), 1600-1605

Production Method 4

64248-62-0

85118-04-3

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide ,  Water Catalysts: (OC-6-42)-Bromodicarbonyl[2-(diphenylphosphino-κP)-N-[2-(diphenylphosphino-κP)et… Solvents: 1,4-Dioxane ;  16 h, 110 °C

Reference

Hydration of Nitriles Enabled by PNP-manganese Pincer Catalyst

Wen, Xiaoting; He, Jingxi; Xi, Hui; Zheng, Qi; Liu, Weiping, Asian Journal of Organic Chemistry, 2022, 11(4),

Production Method 5

64248-62-0

85118-04-3

Reaction Conditions

1.1 Reagents: Cesium carbonate ,  1,8-Diazabicyclo[5.4.0]undec-7-ene Catalysts: Cuprous iodide Solvents: Nitromethane ,  Water ;  2 h, 100 °C

Reference

Copper-Mediated Reactions of Nitriles with Nitromethanes: Aza-Henry Reactions and Nitrile Hydrations

Kuwabara, Jun; Sawada, Yoshiharu; Yoshimatsu, Mitsuhiro, Organic Letters, 2018, 20(4), 1130-1133

Production Method 6

455-86-7

85118-04-3

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Benzene
1.2 Reagents: Ammonia Solvents: Water

Reference

Aromatic fluorine chemistry. Part 1. 3,4-Difluorobenzoic acid and derivatives via 3,4-difluorobenzotrifluoride

Pews, R. G.; Gall, J. A.; Little, J. C., Journal of Fluorine Chemistry, 1990, 50(3), 365-70

Production Method 7

85118-04-3

Reaction Conditions

1.1 Reagents: Allyl bromide Solvents: Methanol ;  6 - 8 h, 60 °C

Reference

Unlocking Amides through Selective C-N Bond Cleavage: Allyl Bromide-Mediated Divergent Synthesis of Nitrogen-Containing Functional Groups

Govindan, Karthick ; Chen, Nian-Qi; Chuang, Yu-Wei; Lin, Wei-Yu, Organic Letters, 2021, 23(24), 9419-9424

Production Method 8

85118-04-3

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Cuprous chloride Solvents: Methanol ;  12 h, rt

Reference

The copper-catalyzed oxidative radical process of site selective C-N bond cleavage in twisted amides: batch and continuous-flow chemistry

Govindan, Karthick; Chen, Nian-Qi; Chen, Hsing-Yin; Hsu, Sodio C. N.; Lin, Wei-Yu, Catalysis Science & Technology, 2023, 13(6), 1633-1639

Production Method 9

455-86-7

85118-04-3

Reaction Conditions

1.1 Reagents: Oxalyl chloride
1.2 Reagents: Ammonium hydroxide Solvents: Dichloromethane ;  0 °C; 3.5 h, rt

Reference

Synthesis, antitumor activity and mechanism of action of novel 1,3-thiazole derivatives containing hydrazide-hydrazone and carboxamide moiety

He, Haifeng; Wang, Xiaoyan; Shi, Liqiao; Yin, Wenyan; Yang, Ziwen; et al, Bioorganic & Medicinal Chemistry Letters, 2016, 26(14), 3263-3270

3,4-Difluorobenzamide Raw materials

• 1-(3,4-difluorophenyl)methanamine
• 3,4-Difluorobenzonitrile
• 3,4-Difluorobenzoic acid

3,4-Difluorobenzamide Preparation Products

• 3,4-Difluorobenzamide (85118-04-3)

• 1. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 2. An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes?
  H. V. Jain,D. Verthelyi,S. L. Beaucage RSC Adv., 2017,7, 42519-42528
• 3. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 4. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 5. An astrophysically-relevant mechanism for amino acid enantiomer enrichment
  Stephen P. Fletcher,Richard B. C. Jagt,Ben L. Feringa Chem. Commun., 2007, 2578-2580

• Pharmaceutical and Biochemical Products Medicinal Building Blocks Fluorine containing Building Blocks

• 455-37-8(3-Fluorobenzamide)
• 132980-99-5(3,5-Difluorobenzamide)
• 78324-75-1(3,4,5-Trifluorobenzamide)
• 824-75-9(4-Fluorobenzamide)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)