Production Method 1

140-75-0

824-75-9

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Manganese oxide Solvents: 2-Methyl-2-butanol ,  Water ;  18 h, 1.5 MPa, 130 °C

Reference

Aerobic Activation of C-H Bond in Amines Over a Nanorod Manganese Oxide Catalyst

Wang, Hai; et al, ChemCatChem, 2019, 11(1), 401-406

Production Method 2

1194-02-1

824-75-9

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Silver tetrafluoroborate ,  Palladium(2+), dichlorobis[μ-[2,7-di(2-pyridinyl-κN)-1,8-naphthyridine-κN1:κN8]]… Solvents: Tetrahydrofuran ,  Water ;  16 h, 50 °C

Reference

Hydrolysis of nitrile catalyzed by a tripalladium complex

Tsai, Zong-Han; et al, Polyhedron, 2023, 239,

Production Method 3

824-75-9

Reaction Conditions

1.1 Reagents: Ammonium carbonate Solvents: Dimethyl sulfoxide ;  6 h, 25 °C

Reference

Transamidation for the Synthesis of Primary Amides at Room Temperature

Chen, Jiajia; et al, Organic Letters, 2020, 22(9), 3504-3508

Production Method 4

403-33-8

824-75-9

Reaction Conditions

1.1 Reagents: Borate(1-), amidotrihydro-, sodium, (T-4)- Solvents: Tetrahydrofuran ;  5 min, rt
1.2 Solvents: Water ;  15 min, rt

Reference

Efficient synthesis of primary and secondary amides via reacting esters with alkali metal amidoboranes

Guo, Yu ; et al, Nature Communications, 2021, 12(1),

Production Method 5

459-23-4

824-75-9

Reaction Conditions

1.1 Catalysts: Ruthenium(1+), chloro[2,2′-(2,6-pyridinediyl-κN)bis[imidazo[1,2-a]pyridine-κN1]]… Solvents: Water ;  12 h, 110 °C

Reference

Highly efficient synthesis of primary amides via aldoximes rearrangement in water under air atmosphere catalyzed by an ionic ruthenium pincer complex

Yang, Fa-Liu; et al, RSC Advances, 2016, 6(43), 37093-37098

Production Method 6

459-56-3

824-75-9

Reaction Conditions

1.1 Reagents: Ammonia ,  Oxygen Catalysts: Cobalt (carbon supported) Solvents: Water ;  24 h, 10 bar, 120 °C

Reference

A "universal" catalyst for aerobic oxidations to synthesize (hetero)aromatic aldehydes, ketones, esters, acids, nitriles, and amides

Senthamarai, Thirusangumurugan; et al, Chem, 2022, 8(2), 508-531

Production Method 7

588-95-4

7304-35-0

824-75-9

Reaction Conditions

1.1 Catalysts: Stereoisomer of di-μ-chlorodichlorobis[(1,2,3,6,7,8-η)-2,7-dimethyl-2,6-octadien… Solvents: Glycerol ,  Water ;  0.5 h, 100 - 120 psi, 150 °C

Reference

Catalytic Rearrangement of Aldoximes to Primary Amides in Environmentally Friendly Media under Thermal and Microwave Heating: Another Application of the Bis(allyl)-Ruthenium(IV) Dimer [{RuCl(μ-Cl)(η3:η3-C10H16)}2]

Gonzalez-Liste, Pedro J.; et al, ACS Sustainable Chemistry & Engineering, 2015, 3(11), 3004-3011

Production Method 8

459-57-4

824-75-9

Reaction Conditions

1.1 Reagents: Sodium bicarbonate ,  Hydroxyamine hydrochloride Catalysts: 2761983-03-1 Solvents: Water ;  2 h, 313 K

Reference

Mechanochemical synthesis of half-sandwich iridium/rhodium complexes with 8-hydroxyquinoline derivatives ligands

Jia, Wei-Guo ; et al, Applied Organometallic Chemistry, 2022, 36(4),

Production Method 9

459-57-4

824-75-9

Reaction Conditions

1.1 Reagents: Hydroxylamine Catalysts: 2925463-30-3 Solvents: Water ;  30 min, 60 °C

Reference

Ru-Based Complexes as Heterogeneous Potential Catalysts for the Amidation of Aldehydes and Nitriles in Neat Water

Arafa, Wael Abdelgayed Ahmed, Bulletin of the Chemical Society of Japan, 2020, 93(9), 1056-1064

Production Method 10

459-57-4

824-75-9

Reaction Conditions

1.1 Reagents: Sodium carbonate ,  Hydroxyamine hydrochloride Catalysts: Cupric acetate ,  N-(2-Aminoethyl)-3-aminopropyltrimethoxysilane (SBA-15 functionalized with, copper complexes) ,  Silica (N-[3-(trimethoxysilyl)propyl]ethylene-diamine-functionalized, copper c…) Solvents: Water ;  2 d, 80 °C
1.2 Solvents: Dichloromethane

Reference

Efficient and selective copper-grafted nanoporous silica in aqueous conversion of aldehydes to amides

Rostamnia, Sadegh; et al, Catalysis Science & Technology, 2015, 5(1), 199-205

Production Method 11

456-22-4

824-75-9

Reaction Conditions

1.1 Reagents: Tripotassium phosphate ,  Diphenylphosphoryl azide Solvents: Dimethylformamide ;  24 h, 100 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water

Reference

Transition-metal-free decarboxylative amidation of aryl α-keto acids with diphenylphosphoryl azide: new avenue for the preparation of primary aryl amides

Xie, Jianwei; et al, Youji Huaxue, 2020, 40(12), 4284-4289

Production Method 12

403-42-9

824-75-9

Reaction Conditions

1.1 Reagents: Iodine ,  Ammonia Solvents: Water ;  1 h, 60 °C

Reference

Novel and Direct Transformation of Methyl Ketones or Carbinols to Primary Amides by Employing Aqueous Ammonia

Cao, Liping; et al, Organic Letters, 2009, 11(17), 3810-3813

Production Method 13

403-42-9

824-75-9

Reaction Conditions

1.1 Reagents: tert-Butyl hydroperoxide ,  Ammonia Catalysts: Tetrabutylammonium iodide Solvents: Water ;  16 h, 100 °C

Reference

TBAI-catalyzed oxidative synthesis of benzamides from acetophenones and carbinols

Sharif, Muhammad; et al, Organic & Biomolecular Chemistry, 2014, 12(33), 6359-6362

Production Method 14

140-75-0

824-75-9

Reaction Conditions

1.1 Reagents: Potassium hydroxide Catalysts: 2506117-64-0 Solvents: Dimethyl sulfoxide ;  60 h, 80 °C

Reference

A new facet of amide synthesis by tandem acceptorless dehydrogenation of amines and oxygen transfer of DMSO

Nie, Xufeng; et al, Journal of Catalysis, 2023, 417, 153-163

Production Method 15

1194-02-1

824-75-9

Reaction Conditions

1.1 Reagents: Water Catalysts: Potassium hydroxide ,  2768104-69-2 Solvents: Isopropanol ;  4 h, 85 °C

Reference

Development of a ruthenium-aquo complex for utilization in synthesis and catalysis for selective hydration of nitriles and alkynes

Saha, Rumpa; et al, New Journal of Chemistry, 2022, 46(19), 9098-9110

Production Method 16

1194-02-1

824-75-9

Reaction Conditions

1.1 Reagents: Water Catalysts: (SP-5-52)-[6-[[Bis(1,1-dimethylethyl)phosphino-κP]methyl]-2-[[bis(1,1-dimethylet… Solvents: tert-Butanol ;  1 d, rt

Reference

Hydration of nitriles using a metal-ligand cooperative ruthenium pincer catalyst

Guo, Beibei; et al, Chemical Science, 2019, 10(45), 10647-10652

Production Method 17

39080-09-6

824-75-9

Reaction Conditions

1.1 Reagents: Potassium periodate Catalysts: Di-μ-chlorodichlorobis[(1,2,3,6,7,8-η)-2,7-dimethyl-2,6-octadiene-1,8-diyl]dirut… Solvents: Water ;  4 h, 100 °C

Reference

Efficient tandem process for the catalytic deprotection of N-allyl amides and lactams in aqueous media: a novel application of the bis(allyl)-ruthenium(IV) catalysts [Ru(η3:η2:η3-C12H18)Cl2] and [{Ru(η3:η3-C10H16)(μ-Cl)Cl}2]

Cadierno, Victorio; et al, Chemistry - A European Journal, 2007, 13(23), 6590-6594

Production Method 18

39887-14-4

824-75-9

Reaction Conditions

1.1 Reagents: Potassium periodate Catalysts: Dichloro[(1,2,3,6,7,10,11,12-η)-2,6,10-dodecatriene-1,12-diyl]ruthenium Solvents: Water ;  3 h, 100 °C

Reference

Efficient tandem process for the catalytic deprotection of N-allyl amides and lactams in aqueous media: a novel application of the bis(allyl)-ruthenium(IV) catalysts [Ru(η3:η2:η3-C12H18)Cl2] and [{Ru(η3:η3-C10H16)(μ-Cl)Cl}2]

Cadierno, Victorio; et al, Chemistry - A European Journal, 2007, 13(23), 6590-6594

Production Method 19

459-23-4

824-75-9

Reaction Conditions

1.1 Catalysts: Iridium(2+), triaqua[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl… Solvents: Water ;  12 h, 110 °C

Reference

Rearrangement of aldoximes to amides in water under air atmosphere catalyzed by water-soluble iridium complex [Cp*Ir(H2O)3][OTf]2

Sun, Chunlou; et al, Catalysis Science & Technology, 2014, 4(4), 988-996

Production Method 20

459-56-3

824-75-9

Reaction Conditions

1.1 Reagents: Ammonia ,  Oxygen Catalysts: Manganese oxide (MnO2) Solvents: 2-Methyl-2-butanol ,  Water ;  24 h, 130 °C

Reference

Product selectivity controlled by manganese oxide crystals in catalytic ammoxidation

Wang, Hai; et al, Chinese Journal of Catalysis, 2021, 42(12), 2164-2172

Production Method 21

459-56-3

824-75-9

Reaction Conditions

1.1 Catalysts: Sodium iodide ,  Polystyrene (reaction product of cupric acetate with Schiff base from acetylacetone…) ,  2,2′-[(1,3-Dimethyl-1,3-propanediylidene)dinitrilo]bis[phenol] Solvents: Dimethylformamide ;  5 d, 110 °C
1.2 Catalysts: Cupric acetate (reaction product of Schiff base from acetylacetone and 2-hydroxyanilin…) Solvents: Dimethylformamide ;  3 h, 110 °C
1.3 Reagents: tert-Butyl hydroperoxide ,  Ammonia ,  Oxygen Solvents: Dimethylformamide ,  Water ;  5 h, 1 atm, 80 °C

Reference

An aerobic oxidative synthesis of aryl nitriles and primary aryl amides from benzylic alcohols catalyzed by a polymer supported Cu(II) complex

Molla, Rostam Ali; et al, New Journal of Chemistry, 2015, 39(2), 921-930

Production Method 22

499-90-1

824-75-9

Reaction Conditions

1.1 Reagents: Ammonium chloride ,  1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Solvents: Acetonitrile ,  Water ;  30 min, rt

Reference

Amide bond formation in aqueous solution: direct coupling of metal carboxylate salts with ammonium salts at room temperature

Tung, Truong Thanh; et al, Organic & Biomolecular Chemistry, 2021, 19(46), 10073-10080

Production Method 23

352-34-1

824-75-9

Reaction Conditions

1.1 Reagents: Sodium azide Catalysts: Poly(methylhydrosiloxane) ,  Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Tetrahydrofuran ,  Water ;  1 atm, 50 °C

Reference

The challenge of palladium-catalyzed aromatic azidocarbonylation: from mechanistic and catalyst deactivation studies to a highly efficient process

Miloserdov, Fedor M.; et al, Organometallics, 2014, 33(3), 736-752

Production Method 24

352-34-1

824-75-9

Reaction Conditions

1.1 Reagents: Poly(methylhydrosiloxane) ,  Sodium azide Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Tetrahydrofuran ,  Water ;  4 h, 1 atm, 50 °C

Reference

Palladium-Catalyzed Aromatic Azidocarbonylation

Miloserdov, Fedor M.; et al, Angewandte Chemie, 2012, 51(15), 3668-3672

Production Method 25

352-34-1

824-75-9

Reaction Conditions

1.1 Reagents: Ammonia Catalysts: Palladium diacetate ,  1,3,5,7-Tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane Solvents: Toluene ,  Water ;  3 - 8 h, 100 psi, 130 °C

Reference

Palladium-catalyzed aminocarbonylation of aryl iodides using aqueous ammonia

Xu, Tongyu; et al, Tetrahedron Letters, 2013, 54(40), 5496-5499

Production Method 26

588-95-4

7304-35-0

824-75-9

Reaction Conditions

1.1 Catalysts: 2135660-74-9 Solvents: Water ;  4 h, 100 °C

Reference

Synthesis and catalytic applications of ruthenium(II)-phosphino-oxime complexes

Francos, Javier; et al, RSC Advances, 2016, 6(45), 39044-39052

Production Method 27

456-22-4

824-75-9

Reaction Conditions

1.1 Reagents: Oxalyl chloride Catalysts: Dimethylformamide Solvents: Dichloromethane ;  1 h, rt
1.2 Reagents: Ammonium hydroxide Solvents: Tetrahydrofuran ;  1 h, 0 °C

Reference

Hit-to-lead optimization of novel phenyl imidazole carboxamides that are active against Leishmania donovani

McNamara, Nicole; et al, European Journal of Medicinal Chemistry, 2022, 240,

Production Method 28

824-75-9

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Ammonia Catalysts: 2257489-47-5 Solvents: Dimethyl sulfoxide ;  1095 torr, cooled; rt; 24 h, 110 °C

Reference

Mechanistic Studies of Palladium-Catalyzed Aminocarbonylation of Aryl Chlorides with Carbon Monoxide and Ammonia

Wang, Justin Y. ; et al, Journal of the American Chemical Society, 2018, 140(25), 7979-7993

Production Method 29

403-42-9

824-75-9

Reaction Conditions

1.1 Reagents: Iodine ,  Ammonia Solvents: Tetrahydrofuran ,  Water ;  1 h, rt

Reference

Novel synthesis of primary arylamides from aryl methyl ketone oxidations using iodine in aqueous ammonia

Angeles, Norma A.; et al, Journal of the Brazilian Chemical Society, 2010, 21(5), 905-908

4-Fluorobenzamide Raw materials

• 4-Fluorobenzaldehyde oxime
• Sodium 4-fluorobenzoate
• Benzamide, 4-fluoro-N-2-propenyl-
• 4-Fluorobenzonitrile
• 4-fluoroacetophenone
• (4-fluorophenyl)methanamine
• 1-Fluoro-4-iodobenzene
• 4-Fluorobenzoic acid
• 4-Fluorobenzaldehyde
• 4-Fluorobenzoic Acid Methyl Ester
• N,N-diallyl-4-fluorobenzamide
• 4-Fluorobenzyl Alcohol
• Benzaldehyde,4-fluoro-, oxime, [C(Z)]-
• (E)-N-(4-fluorophenyl)methylidenehydroxylamine

4-Fluorobenzamide Preparation Products

• 4-Fluorobenzamide (824-75-9)

• 1. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
• 2. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
• 3. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 4. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 5. Enantiocontrolled construction of sistodiolynne, an unusual polyketide from the wood-decay fungus Sistrema raduloides
  Chem. Commun., 1997, 767-768

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Halobenzoic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

• 455-37-8(3-Fluorobenzamide)
• 701-49-5(4-Fluoro-N-methylbenzamide)
• 175278-28-1(5-Fluoro-2-methylbenzamide)
• 85118-04-3(3,4-Difluorobenzamide)
• 132980-99-5(3,5-Difluorobenzamide)
• 78324-75-1(3,4,5-Trifluorobenzamide)
• 445-28-3(2-Fluorobenzamide)
• 261945-92-0(4-Fluoro-3-methylbenzamide)
• 456-07-5(4-fluoro-N-hydroxybenzamide)
• 170726-98-4(3-Fluoro-4-methylbenzamide)