Production Method 1

3939-09-1

85118-02-1

Reaction Conditions

1.1 rt → 34 °C
1.2 Reagents: Hydrogen peroxide Catalysts: Sodium hydroxide Solvents: Water ;  3 h, 34 °C; 1 h, 35 - 40 °C; 40 °C → 5 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  neutralized, 5 °C

Reference

Process for preparation of fluorine substituted benzamides

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2,4-Difluorobenzamide Raw materials

• 2,4-Difluorobenzonitrile

2,4-Difluorobenzamide Preparation Products

• 2,4-Difluorobenzamide (85118-02-1)

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  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 4. Emerging investigators
  Polym. Chem., 2015,6, 5501-5502
• 5. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Halobenzoic acids and derivatives

Professional Introduction to 2,4-Difluorobenzamide (CAS No. 85118-02-1)

2,4-Difluorobenzamide, a compound with the chemical formula C?H?F?NO? and CAS number 85118-02-1, is a fluorinated benzamide derivative that has garnered significant attention in the field of pharmaceutical and chemical research. This compound belongs to a class of molecules that exhibit diverse biological activities, making it a valuable scaffold for the development of novel therapeutic agents.

The structural features of 2,4-difluorobenzamide include two fluorine atoms substituents at the 2nd and 4th positions of the benzene ring, coupled with an amide functional group. The presence of fluorine atoms introduces unique electronic and steric properties to the molecule, which can influence its reactivity, solubility, and binding affinity to biological targets. These characteristics make it an attractive candidate for further exploration in drug discovery and medicinal chemistry.

In recent years, there has been a growing interest in fluorinated aromatic compounds due to their enhanced metabolic stability and improved pharmacokinetic profiles compared to their non-fluorinated counterparts. 2,4-Difluorobenzamide is no exception and has been investigated for its potential applications in various therapeutic areas. One of the most notable areas of research involves its use as an intermediate in the synthesis of bioactive molecules.

Recent studies have demonstrated that 2,4-difluorobenzamide can serve as a key building block in the development of small-molecule inhibitors targeting specific enzymes and receptors involved in diseases such as cancer, inflammation, and neurodegeneration. For instance, researchers have explored its derivatives as potential inhibitors of proteases that play a crucial role in cancer progression. The fluorine atoms in the molecule enhance its binding interactions with these targets, leading to more potent and selective inhibition.

The pharmacological properties of 2,4-difluorobenzamide have also been studied in the context of anti-inflammatory therapies. By modifying its structure, scientists have synthesized analogs that exhibit significant anti-inflammatory activity without causing severe side effects. This has opened up new avenues for treating chronic inflammatory conditions such as rheumatoid arthritis and inflammatory bowel disease.

Beyond its applications in drug development, 2,4-difluorobenzamide has found utility in materials science and chemical synthesis. Its unique electronic properties make it a valuable component in the design of organic electronic materials, including light-emitting diodes (LEDs) and organic photovoltaic cells. Additionally, its role as a versatile intermediate in synthetic chemistry has been leveraged to create complex molecules with tailored properties for industrial applications.

The synthesis of 2,4-difluorobenzamide typically involves multi-step organic reactions that require careful optimization to achieve high yields and purity. Common synthetic routes include nucleophilic aromatic substitution reactions on halogenated benzene derivatives followed by amide bond formation. Advances in synthetic methodologies have enabled more efficient and sustainable production processes for this compound.

In conclusion, 2,4-difluorobenzamide (CAS No. 85118-02-1) is a multifaceted compound with significant potential in pharmaceutical research and industrial applications. Its structural features and biological activities make it a valuable tool for developing novel therapeutics targeting various diseases. As research continues to uncover new applications for this compound, its importance in the chemical and pharmaceutical industries is likely to grow even further.

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