Production Method 1

1513-66-2

851178-99-9

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  2 h, -75 °C
1.2 Reagents: CFC 113 ;  1 h, -75 °C

Reference

Removal of fluorine from and introduction of fluorine into polyhalopyridines: an exercise in nucleophilic hetarenic substitution

Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred, Chemistry - A European Journal, 2005, 11(6), 1903-1910

Production Method 2

1513-66-2

851178-99-9

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ,  Hexane ;  1 h, -75 °C
1.2 Reagents: CFC 113 ;  1 h, -75 °C
1.3 Reagents: Water

Reference

Selective Functionalization of 2-Fluoropyridine, 2,3-Difluoropyridine, and 2,5-Difluoropyridine at Each Vacant Position

Bobbio, Carla; Schlosser, Manfred, Journal of Organic Chemistry, 2005, 70(8), 3039-3045

4-Chloro-2,3-difluoropyridine Raw materials

• 2,3-Difluoropyridine

4-Chloro-2,3-difluoropyridine Preparation Products

• 4-Chloro-2,3-difluoropyridine (851178-99-9)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines

• 52026-98-9(4-Chloro-2,3,5,6-tetrafluoropyridine)
• 2879-42-7(3-Chloro-2,5,6-trifluoropyridine)
• 52026-99-0(3,4-Dichloro-2,5,6-trifluoropyridine)
• 52208-55-6(5-CHLORO-2,3,4-TRIFLUOROPYRIDINE)
• 63489-53-2(4-Chloro-2,3,6-trifluoropyridine)
• 1735-84-8(3-Chloro-2,4,5,6-tetrafluoropyridine)
• 589402-43-7(2,3-difluoro-5-chloro pyridine)
• 89402-43-7(5-Chloro-2,3-difluoropyridine)
• 54889-43-9(2,4-Dichloro-3,5,6-trifluoropyridine)
• 851386-40-8(4-Chloro-2,5-difluoropyridine)