Production Method 1

452-74-4

85070-67-3

Reaction Conditions

1.1 Solvents: Dimethylformamide ;  24 h, rt → reflux; reflux → rt
1.2 Reagents: Ammonia Solvents: Diethyl ether ,  Water ;  1 h, rt

Reference

A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F···CN interactions

Olsen, Jacob; Seiler, Paul; Wagner, Bjoern; Fischer, Holger; Tschopp, Thomas; et al, Organic & Biomolecular Chemistry, 2004, 2(9), 1339-1352

Production Method 2

452-74-4

85070-67-3

Reaction Conditions

1.1 Solvents: Dimethylformamide ;  5 h, reflux

Reference

Non-covalent thrombin inhibitors featuring P3-Heterocycles with P1-Bicyclic arginine surrogates

Cui, Jingrong Jean; Araldi, Gian-Luca; Reiner, John E.; Reddy, Komandla Malla; Kemp, Scott J.; et al, Bioorganic & Medicinal Chemistry Letters, 2002, 12(20), 2925-2930

2-Fluoro-4-methylbenzonitrile Raw materials

• 1-bromo-2-fluoro-4-methyl-benzene

2-Fluoro-4-methylbenzonitrile Preparation Products

• 2-Fluoro-4-methylbenzonitrile (85070-67-3)

• 1. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 2. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 3. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 4. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 5. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzonitriles
• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

• 64248-64-2(2,5-Difluorobenzonitrile)
• 185147-07-3(2-Fluoro-3-methylbenzonitrile)
• 508203-48-3(2,3-Difluoro-4-methylbenzonitrile)
• 64113-84-4(2-Fluoro-5-methylbenzonitrile)
• 21524-39-0(2,3-Difluorobenzonitrile)
• 1897-53-6(2-Fluoroterephthalonitrile)
• 394-47-8(2-Fluorobenzonitrile)
• 170572-49-3(3-Fluoro-4-methylbenzonitrile)
• 13519-90-9(4-fluorobenzene-1,3-dicarbonitrile)
• 198633-76-0(2-Fluoro-6-methylbenzonitrile)