Production Method 1

23783-42-8

85030-56-4

Reaction Conditions

1.1 Reagents: Triethylamine ,  Methanesulfonyl chloride Solvents: Dichloromethane ;  0 °C; overnight, 0 - 5 °C; 5 °C → rt
1.2 Reagents: Ammonia ,  Ammonium chloride Solvents: Water ;  48 h, rt

Reference

Self-Assembly Can Direct Dynamic Covalent Bond Formation toward Diversity or Specificity

Komaromy, David; et al, Journal of the American Chemical Society, 2017, 139(17), 6234-6241

Production Method 2

130955-37-2

85030-56-4

Reaction Conditions

1.1 Reagents: Ammonium acetate ,  Ammonia Solvents: Water ;  48 h, rt

Reference

Site-selective modification of peptides and proteins via interception of free-radical-mediated dechalcogenation

Griffiths, Rhys C.; et al, Angewandte Chemie, 2020, 59(52), 23659-23667

Production Method 3

23783-42-8

85030-56-4

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  0 °C; overnight, 0 - 5 °C; 5 °C → rt
2.1 Reagents: Ammonia ,  Ammonium chloride Solvents: Water ;  48 h, rt

Reference

Self-Assembly Can Direct Dynamic Covalent Bond Formation toward Diversity or Specificity

Komaromy, David; et al, Journal of the American Chemical Society, 2017, 139(17), 6234-6241

Production Method 4

23783-42-8

85030-56-4

Reaction Conditions

1.1 Reagents: Triphenylphosphine ,  Diisopropyl azodicarboxylate Solvents: Dichloromethane ;  0 °C; 24 h
2.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ;  12 h, reflux

Reference

Morphology Optimization via Side Chain Engineering Enables All-Polymer Solar Cells with Excellent Fill Factor and Stability

Liu, Xi; et al, Journal of the American Chemical Society, 2018, 140(28), 8934-8943

Production Method 5

23783-42-8

85030-56-4

Reaction Conditions

1.1 Reagents: Triphenylphosphine Solvents: Tetrahydrofuran ;  rt; 15 min, rt
1.2 Reagents: Diisopropyl azodicarboxylate ;  rt; 12 h, rt
2.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ;  overnight, reflux; reflux → rt
2.2 Reagents: Hydrochloric acid Solvents: Water ;  rt
2.3 Reagents: Sodium carbonate Solvents: Water ;  pH 10, rt

Reference

Synthesis and Properties of Alternating Polypeptoids and Polyampholytes as Protein-Resistant Polymers

Tao, Yue; et al, Biomacromolecules, 2018, 19(3), 936-942

Production Method 6

62921-76-0

85030-56-4

Reaction Conditions

1.1 Reagents: Sodium azide Solvents: Dimethylformamide ;  3 d, 60 °C
2.1 Reagents: Triphenylphosphine Solvents: Tetrahydrofuran ,  Water ;  3 h, rt

Reference

Tuneable Transient Thermogels Mediated by a pH- and Redox-Regulated Supramolecular Polymerization

Spitzer, Daniel; et al, Angewandte Chemie, 2017, 56(48), 15461-15465

Production Method 7

23783-42-8

85030-56-4

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Tetrahydrofuran ,  Water ;  0 °C; 3 h, 0 °C → rt
2.1 Solvents: Dimethylformamide ;  12 h, 80 °C
3.1 Reagents: Hydrazine hydrate (1:1) Solvents: Methanol ;  3 h, reflux
3.2 Reagents: Sodium hydroxide Solvents: Water

Reference

Influence of Side Chains on the n-Type Organic Electrochemical Transistor Performance

Ohayon, David; et al, ACS Applied Materials & Interfaces, 2021, 13(3), 4253-4266

Production Method 8

85030-56-4

7407-59-2

Reaction Conditions

1.1 Reagents: Water

Reference

Synthesis and pH-dependent hydrolysis profiles of mono- and dialkyl substituted maleamic acids

Su, Shan; et al, Organic & Biomolecular Chemistry, 2017, 15(39), 8384-8392

Production Method 9

606130-90-9

85030-56-4

Reaction Conditions

1.1 Reagents: Triphenylphosphine Solvents: Tetrahydrofuran ,  Water ;  2 d, rt

Reference

Tuneable pH-regulated supramolecular copolymerisation by mixing mismatched dendritic peptide comonomers

Ahlers, P.; et al, Polymer Chemistry, 2015, 6(41), 7245-7250

Production Method 10

606130-90-9

85030-56-4

Reaction Conditions

1.1 Reagents: Triphenylphosphine Solvents: Tetrahydrofuran ;  0 °C; 24 h, rt
1.2 Solvents: Water ;  24 h, rt

Reference

Nanowells on Silica Particles in Water Containing Long-Distance Porphyrin Heterodimers

Li, Guangtao; et al, Journal of the American Chemical Society, 2003, 125(35), 10693-10702

Production Method 11

606130-90-9

85030-56-4

Reaction Conditions

1.1 Reagents: Triphenylphosphine Solvents: Tetrahydrofuran ;  rt; 5 h, rt
1.2 Reagents: Water ;  overnight, 80 °C

Reference

N-monosubstituted methoxy-oligo(ethylene glycol) carbamate ester prodrugs of resveratrol

Mattarei, Andrea; et al, Molecules, 2015, 20(9), 16085-16102

Production Method 12

199445-54-0

85030-56-4

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ;  12 h, reflux

Reference

Morphology Optimization via Side Chain Engineering Enables All-Polymer Solar Cells with Excellent Fill Factor and Stability

Liu, Xi; et al, Journal of the American Chemical Society, 2018, 140(28), 8934-8943

Production Method 13

110429-45-3

85030-56-4

Reaction Conditions

1.1 Reagents: Potassium phthalimide Solvents: Dimethylformamide ;  rt; 3 h, 80 °C
1.2 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ;  rt; 4 h, 60 °C

Reference

Direct Ordering of Anchoring Events at the Surface of Iron Oxide Nanoparticles Enabled by A Stepwise Phase-Transfer Strategy

Okada, Yohei ; et al, ChemistrySelect, 2018, 3(29), 8458-8461

Production Method 14

130955-37-2

85030-56-4

Reaction Conditions

1.1 Reagents: Ammonia ,  Ammonium chloride Solvents: Water ;  48 h, rt

Reference

Self-Assembly Can Direct Dynamic Covalent Bond Formation toward Diversity or Specificity

Komaromy, David; et al, Journal of the American Chemical Society, 2017, 139(17), 6234-6241

Production Method 15

110429-45-3

1074-82-4

85030-56-4

Reaction Conditions

1.1 Solvents: Dimethylformamide ;  rt; 3 h, 80 °C
2.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ;  rt; 4 h, 60 °C

Reference

Direct Ordering of Anchoring Events at the Surface of Iron Oxide Nanoparticles Enabled by A Stepwise Phase-Transfer Strategy

Okada, Yohei ; et al, ChemistrySelect, 2018, 3(29), 8458-8461

Production Method 16

1074-82-4

62921-76-0

85030-56-4

Reaction Conditions

1.1 Solvents: Dimethylformamide ;  90 °C
2.1 Reagents: Hydrazine hydrate (1:1) Solvents: Methanol ;  80 °C

Reference

All-Solid-State Vertical Three-Terminal N-Type Organic Synaptic Devices for Neuromorphic Computing

Xie, Zhichao ; et al, Advanced Functional Materials, 2022, 32(21),

Production Method 17

1074-82-4

62921-76-0

85030-56-4

Reaction Conditions

1.1 Solvents: Dimethylformamide ;  12 h, 80 °C
2.1 Reagents: Hydrazine hydrate (1:1) Solvents: Methanol ;  3 h, reflux
2.2 Reagents: Sodium hydroxide Solvents: Water

Reference

Influence of Side Chains on the n-Type Organic Electrochemical Transistor Performance

Ohayon, David; et al, ACS Applied Materials & Interfaces, 2021, 13(3), 4253-4266

Production Method 18

23783-42-8

85030-56-4

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  0 °C; 0 °C → rt; 2 h, rt
2.1 Reagents: Ammonium acetate ,  Ammonia Solvents: Water ;  48 h, rt

Reference

Site-selective modification of peptides and proteins via interception of free-radical-mediated dechalcogenation

Griffiths, Rhys C.; et al, Angewandte Chemie, 2020, 59(52), 23659-23667

Production Method 19

62921-76-0

85030-56-4

Reaction Conditions

1.1 Reagents: Sodium azide Solvents: Acetone ,  Water ;  overnight, 75 °C
2.1 Reagents: Triphenylphosphine Solvents: Tetrahydrofuran ;  rt; 5 h, rt
2.2 Reagents: Water ;  overnight, 80 °C

Reference

N-monosubstituted methoxy-oligo(ethylene glycol) carbamate ester prodrugs of resveratrol

Mattarei, Andrea; et al, Molecules, 2015, 20(9), 16085-16102

Production Method 20

62921-76-0

85030-56-4

Reaction Conditions

1.1 Reagents: Sodium azide Solvents: Dimethylformamide ;  3 d, 60 °C
2.1 Reagents: Triphenylphosphine Solvents: Tetrahydrofuran ,  Water ;  2 d, rt

Reference

Tuneable pH-regulated supramolecular copolymerisation by mixing mismatched dendritic peptide comonomers

Ahlers, P.; et al, Polymer Chemistry, 2015, 6(41), 7245-7250

Production Method 21

112-60-7

85030-56-4

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Chloroform ;  30 min, 0 °C
1.2 Solvents: Chloroform ;  0 °C; 2.5 h, rt; 10 h, rt → reflux; reflux → 0 °C
1.3 Solvents: Water
2.1 Solvents: Dimethylformamide ;  overnight, 110 °C
2.2 Solvents: Water
3.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ;  1 h, reflux

Reference

Novel Glycosylated Naphthalimide-Based Activatable Fluorescent Probe: A Tool for the Assessment of Hexosaminidase Activity and Intracellular Hexosaminidase Imaging

Dong, Lili; et al, ACS Sensors, 2019, 4(5), 1222-1229

Production Method 22

23783-42-8

85030-56-4

Reaction Conditions

1.1 Reagents: Sodium hydride ;  0 °C; rt
1.2 Solvents: Tetrahydrofuran ;  0 °C; rt
2.1 Solvents: Dimethylformamide ;  90 °C
3.1 Reagents: Hydrazine hydrate (1:1) Solvents: Methanol ;  80 °C

Reference

All-Solid-State Vertical Three-Terminal N-Type Organic Synaptic Devices for Neuromorphic Computing

Xie, Zhichao ; et al, Advanced Functional Materials, 2022, 32(21),

Production Method 23

85030-56-4

616-02-4

85030-56-4

7407-59-2

Reaction Conditions

1.1 Solvents: Dichloromethane ;  24 h, 30 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water
2.1 Reagents: Water

Reference

Synthesis and pH-dependent hydrolysis profiles of mono- and dialkyl substituted maleamic acids

Su, Shan; et al, Organic & Biomolecular Chemistry, 2017, 15(39), 8384-8392

m-PEG4-Amine Raw materials

• Tetraethylene glycol
• m-PEG4-Amine
• m-PEG4-Br
• m-PEG4-Ms
• 3-methyl-2,5-dihydrofuran-2,5-dione
• m-PEG4-azide
• Tetraethylene glycol monomethyl ether
• potassium 1,3-dioxo-2,3-dihydro-1H-isoindol-2-ide
• 1H-Isoindole-1,3(2H)-dione, 2-(3,6,9,12-tetraoxatridec-1-yl)-
• 2,5,8,11-Tetraoxatridecan-13-YL 4-methylbenzenesulfonate

m-PEG4-Amine Preparation Products

• m-PEG4-Amine (85030-56-4)
• 2-methylbut-2-enedioic acid (7407-59-2)

• 1. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 2. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 3. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 4. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 5. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466

• Other Chemical additives

• 5498-83-9(m-PEG5-NH2)
• 211859-73-3(m-PEG9-Amine)
• 929-75-9(Amino-PEG3-C2-Amine)
• 32130-27-1(m-PEG36-amine)
• 170572-38-0(m-PEG7-Amine)
• 184357-46-8(m-PEG6-Amine)
• 869718-81-0(m-PEG8-Amine)
• 6338-55-2(NH2-PEG3)
• 929-59-9(Bis-NH2-PEG2)
• 68960-97-4(Amino-PEG4-C2-amine)