Production Method 1

112677-93-7

85-32-5

Reaction Conditions

1.1 Reagents: Formic acid ,  Butylamine ,  Triphenylphosphine Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Tetrahydrofuran
1.2 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran

Reference

A general approach to nucleoside 3'- and 5'-monophosphates

Hayakawa, Y.; et al, Tetrahedron Letters, 1987, 28(20), 2259-62

Production Method 2

118-00-3

78-40-0

85-32-5

Reaction Conditions

1.1 Reagents: Triethyl phosphate ,  Phosphorus oxychloride Solvents: Water

Reference

Phosphorylation of nucleosides with phosphorus oxychloride in trialkyl phosphate

Ikemoto, Tomoni; et al, Chemical & Pharmaceutical Bulletin, 1995, 43(2), 210-15

Production Method 3

118-00-3

330-13-2

85-32-5

Reaction Conditions

Reference

Enzymic 5'-monophosphorylation of modified nucleosides

Zinchenko, A. I.; et al, Khimiya Prirodnykh Soedinenii, 1989, (5), 732-3

Production Method 4

118-00-3

56-65-5

85-32-5

Reaction Conditions

1.1 Catalysts: Inosine kinase

Reference

Phosphorylation of guanosine using guanosine-inosine kinase from Exiguobacterium acetylicum coupled with ATP regeneration

Kawasaki, Hisashi; et al, Bioscience, 2000, 64(10), 2259-2261

Production Method 5

85-32-5

85-32-5

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Sodium nitrate Solvents: Water ;  25 °C

Reference

Equilibrium Studies on Complex-Formation Reactions of Pd[(2-(2-aminoethyl)pyridine)(H2O)2]2+ with Ligands of Biological Significance and Displacement Reactions of DNA Constituents

Shehata, Mohamed R.; et al, European Journal of Inorganic Chemistry, 2009, (26), 3912-3920

Production Method 6

85-32-5

Reaction Conditions

1.1 Reagents: Sodium chloride Solvents: Water ;  pH 4, 25 °C

Reference

Experimental and Computational Evidence for a Loose Transition State in Phosphoroimidazolide Hydrolysis

Li, Li; et al, Journal of the American Chemical Society, 2016, 138(12), 3986-3989

Production Method 7

85-32-5

85-32-5

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water-d2 ;  pH 3, 22 °C

Reference

Chiral discrimination in the formation reaction and at equilibrium for N,N,N',N'-tetramethyl-1,2-diaminocyclohexane-PtG2 complexes

Benedetti, Michele; et al, Dalton Transactions, 2003, (5), 872-879

Production Method 8

85-32-5

85-32-5

Reaction Conditions

1.1 Reagents: Sodium nitrate Solvents: Water ;  25 °C

Reference

Potentiometric studies of ternary complexes involving ethylenediamine N,N'-diacetic acid (EDDA) palladium(II) and some bioligands

Ammar, R. A. A., Fluid Phase Equilibria, 2009, 285(1-2), 116-121

Production Method 9

85-32-5

Reaction Conditions

1.1 Reagents: Sodium chloride Solvents: Water ;  pH 4, 25 °C

Reference

Experimental and Computational Evidence for a Loose Transition State in Phosphoroimidazolide Hydrolysis

Li, Li; et al, Journal of the American Chemical Society, 2016, 138(12), 3986-3989

Production Method 10

85-32-5

Reaction Conditions

1.1 Reagents: Silver nitrate ,  Terbium nitrate Solvents: Water ;  2 h, rt

Reference

Multiple switchable circularly polarized luminescence from nucleotide/terbium(III) complexes

Yang, Chujing; et al, New Journal of Chemistry, 2023, 47(9), 4472-4477

Production Method 11

362-76-5

85-32-5

Reaction Conditions

1.1 Reagents: Anthraquinone ,  Phosphorus trichloride ,  Oxygen Solvents: 1,4-Dioxane
1.2 Solvents: Water

Reference

Further studies on the reaction of guanosine derivatives with phosphorus trichloride

Maruyama, Tokumi; et al, Chemical & Pharmaceutical Bulletin, 1986, 34(2), 471-8

Production Method 12

85-32-5

85-32-5

Reaction Conditions

1.1 Solvents: Acetonitrile ;  4 d, rt

Reference

Synthesis and characterization of a new Au(III)-pyridine-carboxamide complex and its reaction with 5'-GMP

Yang, Ting; et al, Wuji Huaxue Xuebao, 2003, 19(1), 45-48

Production Method 13

523-98-8

85-32-5

Reaction Conditions

Reference

Preparation of inosine and nucleotides of 5'-guanylic acid

, France, , ,

Production Method 14

5550-12-9

85-32-5

Reaction Conditions

1.1 Reagents: Dowex 50W Solvents: Water

Reference

Convenient syntheses of cytidine 5'-triphosphate, guanosine 5'-triphosphate, and uridine 5'-triphosphate and their use in the preparation of UDP-glucose, UDP-glucuronic acid, and GDP-mannose

Simon, Ethan S.; et al, Journal of Organic Chemistry, 1990, 55(6), 1834-41

Production Method 15

85-32-5

85-32-5

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water-d2 ;  pH 3, 22 °C

Reference

Chiral discrimination in the formation reaction and at equilibrium for N,N,N',N'-tetramethyl-1,2-diaminocyclohexane-PtG2 complexes

Benedetti, Michele; et al, Dalton Transactions, 2003, (5), 872-879

Production Method 16

68892-41-1

85-32-5

Reaction Conditions

1.1 -
1.2 Reagents: Dichloroacetic acid Solvents: Dichloromethane ;  1 min, rt
1.3 Reagents: 1H-Tetrazole Solvents: Acetonitrile ;  2 min, rt
1.4 Reagents: Phosphoramidous acid, N,N-bis(1-methylethyl)-, bis[[4-(triphenylmethoxy)phenyl]m… Solvents: Acetonitrile ;  2 min, rt
1.5 Reagents: Pyridine ,  Iodine Solvents: Tetrahydrofuran ,  Water ;  10 min, rt
1.6 Reagents: Ammonium hydroxide Solvents: Water ;  5 h, 50 °C

Reference

New phosphorylating reagents for deoxyribonucleosides and oligonucleotides

Romanucci, Valeria ; et al, Tetrahedron Letters, 2017, 58(12), 1227-1229

5-Guanylic Acid Raw materials

• Guanosine
• 2',3'-O-Isopropylideneguanosine
• Disodium 5'-guanylate
• Triethyl phosphate
• Adenosine 5'-Triphosphate
• 5'-Xanthylic acid
• 5'-Guanylic acid, 2',3'-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-, di-2-propenyl ester (9CI)
• 5'-O-DMT-N2-ibu-dG
• 5-Guanylic Acid
• 4-Nitrophenyl phosphate

5-Guanylic Acid Preparation Products

• 5-Guanylic Acid (85-32-5)

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• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides Purine ribonucleoside monophosphates
• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides Purine ribonucleotides Purine ribonucleoside monophosphates
• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Other Chemical Reagents

• 65128-55-4(5'-Guanylic acid,monomethyl ester (9CI))
• 3254-39-5(5'-Guanylic acid,dipotassium salt (7CI,8CI,9CI))
• 54684-83-2(polyguanylic acid (5') potassium salt)
• 38966-30-2(Calcium 5'-guanylate)
• 11063-40-4(5'-Guanylic acid, cobalt(2+) salt (1:1) (8CI,9CI))
• 11063-53-9(5'-Guanylic acid, zinc salt (1:1) (8CI,9CI))
• 22886-44-8(Guanosine, guanylyl-(2'®5')- (7CI,8CI,9CI))
• 24121-01-5(5'-Guanylic acid, 2'-O-methyl-)
• 179382-90-2(5'-Guanylic-8-t acid,diammonium salt (9CI))
• 11063-44-8(5'-Guanylic acid, copper(2+) salt (1:1) (8CI,9CI))